Neue Perzentilwerte für die Körpermaße neugeborener Zwillinge: Ergebnisse der deutschen Perinatalerhebung der Jahre 2007–2011 unter Beteiligung aller 16 Bundesländer

Voigt, M; Rochow, Niels; Schneider, K. T. M.; Hagenah, HP; Straube, Sebastian; Scholz, Rembrandt D.; Hesse,; Hentschel, Roland; Olbertz, Dirk

doi:10.1055/s-0034-1385858

Cited by 40 publications

(3 citation statements)

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“…Odds ratios (ORs) for major birth defects and preterm birth were determined using logistic regression. The standard deviation score (SDS) for birth weights and head circumference was calculated based on percentiles derived from the German perinatal survey 13,14 …”

Section: Methodsmentioning

confidence: 99%

Antiepileptic treatment with levetiracetam during the first trimester and pregnancy outcome: An observational study

Hoeltzenbein,

Bartz,

Fietz

et al. 2023

Epilepsia

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ObjectiveLevetiracetam is increasingly used in pregnant women with epilepsy. Although teratogenic effects have not been observed so far, data on the risks of spontaneous abortion and major birth defects are still limited, especially for the frequently used dual therapy of levetiracetam and lamotrigine. Our primary aim was to analyse rates of major birth defects and spontaneous abortion after maternal levetiracetam treatment.MethodsCohort study based on pregnancies recorded by the Embryotox Center from 2000‐2017. Outcomes of prospectively ascertained pregnancies with first trimester levetiracetam monotherapy (n=221) were compared to pregnancies with lamotrigine monotherapy for epilepsy (n=469). In addition, all pregnancies with levetiracetam (n=364) exposure during the first trimester were analysed in comparison to a non‐exposed cohort (n=729). Pregnancies with the most frequently used combination therapy comprising levetiracetam and lamotrigine (n=80) were evaluated separately.ResultsThere was no significantly increased risk for major birth defects or for spontaneous abortions after first trimester exposure to levetiracetam. Birth weight of male neonates was significantly lower after levetiracetam monotherapy compared to lamotrigine monotherapy. Dual therapy with levetiracetam and lamotrigine resulted in a significantly increased risk for spontaneous abortion (HRadj 3.01, 95% CI 1.43 ‐ 6.33) and a non‐significant effect estimate for major birth defects (7.7%, n=5/65; ORadj 1.47, 95% CI 0.48 ‐ 4.47) compared to a non‐exposed cohort.SignificanceOur study confirms the use of levetiracetam as suitable antiepileptic drug in pregnancy. The lower birth weight of male neonates after maternal levetiracetam monotherapy and the unexpectedly high risk for spontaneous abortion and birth defects after dual therapy with levetiracetam and lamotrigine require further investigation.

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Section: Methodsmentioning

confidence: 99%

Antiepileptic treatment with levetiracetam during the first trimester and pregnancy outcome: An observational study

Hoeltzenbein,

Bartz,

Fietz

et al. 2023

Epilepsia

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“…The following data were collected: maternal age, ethnicity, body mass index (BMI), parity, placental location, GA at diagnosis, TTTS stage, sFGR type, UA Doppler pattern (AREDF), DV Doppler pattern (absent or reversed A-wave (ARF)), EFW, EFW percentile, intertwin EFW discordance, cervical length, GA at surgery, type of surgery, duration of surgery (from insertion to removal of the trocar), miscarriage (spontaneous delivery < 24 weeks of gestation without twin survivors), preterm premature rupture of the membranes (PPROM), GA at delivery, type of delivery, survival at birth, birthweight (BW) of live births, BW percentile [20], intertwin BW discordance of living twin siblings (difference between BW of the larger twin and the smaller twin divided by BW of the larger twin multiplied by 100), and neonatal survival (28 days after birth).…”

Section: Analyzed Datamentioning

confidence: 99%

The Outcome after Laser Therapy of Monochorionic Twin Pregnancies Complicated by Twin-Twin Transfusion Syndrome with Coexistent Selective Fetal Growth Restriction

Ortiz,

Guggenberger,

Graupner

et al. 2024

JCM

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Background: Most previous studies evaluated outcomes of twin–twin transfusion syndrome (TTTS) without considering the coexistence of selective fetal growth restriction (sFGR). The objectives of this study were to compare twin survival and pregnancy complications after laser therapy of TTTS with and without sFGR. Methods: For this purpose, a retrospective cohort study including 98 monochorionic diamniotic twins and three dichorionic triamniotic triplets treated in a single tertiary center was conducted. Results: Overall, 46 twins had selective fetal growth restriction (26 type I, 13 type II, 7 type III). At birth, donor survival (61% vs. 91%), double survival (57% vs. 82%), and overall survival (75% vs. 88%) were significantly lower in the group with coexistent sFGR. Recipient survival (89% vs. 86%), miscarriage (7% vs. 2%), PPROM < 32 weeks (48% vs. 29%), and preterm delivery < 32 weeks (52% vs. 45%) were not significantly higher in the group with coexistent sFGR. Donor twins with sFGR type I (69% vs. 91%) and types II–III (50% vs. 91%) showed significantly lower survival than those without sFGR. Multivariate regression analysis identified sFGR and its subtypes as independent predictors of donor demise. Conclusions: the coexistence of sFGR in TTTS pregnancies was associated with poor donor outcomes and is probably the most important predictor of donor survival.

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“…Die Daten unterliegen somit einer Negativselektion von kränkeren und kleineren Frühgeborenen. Diese potenziellen Schwächen der Ergebnisqualität wirkt allerdings die hohe Fallzahl der hier analysierten Geburten entgegen [1][2][3].…”

Section: Sehr Geehrte Herausgeberunclassified

Vergleich der Perzentilkurven von Körpermaßen neugeborener Einlinge, Zwillinge und Drillinge

Voigt

Hentschel

Kunze

et al. 2017

Z Geburtshilfe Neonatol

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Neue Perzentilwerte für die Körpermaße neugeborener Zwillinge: Ergebnisse der deutschen Perinatalerhebung der Jahre 2007–2011 unter Beteiligung aller 16 Bundesländer

Abstract: We recommend using the new percentile values instead of the old ones.

Cited by 40 publications

References 0 publications

Antiepileptic treatment with levetiracetam during the first trimester and pregnancy outcome: An observational study

Antiepileptic treatment with levetiracetam during the first trimester and pregnancy outcome: An observational study

The Outcome after Laser Therapy of Monochorionic Twin Pregnancies Complicated by Twin-Twin Transfusion Syndrome with Coexistent Selective Fetal Growth Restriction

Vergleich der Perzentilkurven von Körpermaßen neugeborener Einlinge, Zwillinge und Drillinge

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