Neue Komplexane XXII. N-Carboxymethyliminoacethydroxam- und Iminodiacethydroxamsäure

Karlíček, R.; Majer, J.

doi:10.1135/cccc19720151

Cited by 8 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[76] The authors also compared their data to IV. As can be seen in Table 2, VI formed slightly stronger com- [85] (II) EDTPHA, [69] (III) DHA, [70] (IV) no abbreviation given, [72] (V) no abbreviation given, [72] (VI) H 4 CDTMAHA, [76] (VII) CYTROX, [74] (VIII) 3,4,3-LI(1,2-HOPO), [82][83][84]86] (IX) Calix(HYD) 4 , [80] (X) TAM(HOPO) 2 , [79] (XI) BAMPTH, [50,70,71] (XII) no abbreviation given. [87] plexes with Fe III and Th IV than IV,t hough they were comparable in selectivity.…”

Section: Small Moleculesmentioning

confidence: 76%

“…This ligand wass hown to preferentially form a1 :1 complex with Cu II and Fe III despite variationso fl igand:metal ratios, also demonstrating the lack of chelate effect noted by Schwarzenbach. [69] Martell et al suggested al inear relationship between the logK of ligandsc ontaining only negative oxygen atoms and the logK(OH) of the metal ions could be used to predict the affinity of metal ions for O-donor ligands. This linear relationship was shownt oh old true for DFOB, BAMPTH, andaseries of dihydroxamic acids with varying linker chains (C n DHA, III, Figure3).…”

Section: Small Moleculesmentioning

confidence: 99%

See 1 more Smart Citation

Beyond Biological Chelation: Coordination of f‐Block Elements by Polyhydroxamate Ligands

Sockwell

Wetzler

2018

Chemistry A European J

View full text Add to dashboard Cite

The promise of polyhydroxamic acid ligands for the selective chelation of the f-elements is becoming increasingly more apparent. The initial studies of polyhydroxamic acid siderophores showed the formation of highly stable complexes with Pu(IV), but a higher preference for Fe(III) hindered effective applications. The development of synthetic routes toward highly pure and customizable ligands containing multiple hydroxamic acids allowed for the growth of new classes of compounds. While the first round of these ligands focused on the incorporation of siderophore-like frameworks, the new synthetic strategies led to small molecules of various frameworks and even resins for applications in the field of f-element separations and biological desorption. Unfortunately, a lack of consistent stability constant data makes direct comparisons across this body of work difficult. More studies into the stability constants and separations of the f-elements in a variety of pH ranges is necessary to truly realize the potential for polyhydroxamic acid ligands.

show abstract

Section: Small Moleculesmentioning

confidence: 76%

Section: Small Moleculesmentioning

confidence: 99%

Beyond Biological Chelation: Coordination of f‐Block Elements by Polyhydroxamate Ligands

Sockwell

Wetzler

2018

Chemistry A European J

View full text Add to dashboard Cite

show abstract

“…A brief analysis of the global formation the corresponding value for iminodihydroxamic acid (IDHA, log K 1 = 5.66). 23 The fairly acidic character of this protonated amine group should be due to some electron-withdrawing effect of the amide groups in its vicinity as well as to some stabilization of the conjugated base by hydrogen bonding (amide -NH to N-amine) through the formation of stable five-membered rings.…”

Section: Protonationmentioning

confidence: 99%

A new bis(3-hydroxy-4-pyridinone)-IDA derivative as a potential therapeutic chelating agent. Synthesis, metal-complexation and biological assays

Santos¹,

Gama²,

Gano

et al. 2004

Dalton Trans.

View full text Add to dashboard Cite

A new bis(3-hydroxy-4-pyridinone) derivative of iminodiacetic acid, imino-bis(acetyl(1-(3'-aminopropyl)-3-hydroxy-2-methyl-4-pyridinone)), IDAPr(3,4-HP)(2), has been prepared and studied in its interaction with a set of hard metal ions. This tetradentate ligand presents a much higher chelating efficiency for trivalent hard metal ions (Fe, Ga, Al) than the monodentate derivative Deferriprone, namely at the diluted conditions prevailing in physiological conditions and at low clinical doses. A similar behaviour was also observed for the complexation with Zn(II) but at a significantly lower extent. This compound presents a moderate hydrophilic character at physiological pH (logD=-1.72). In vivo assays showed much more rapid clearance of (67)Ga from most tissues of metal-loaded mice than the drug Deferriprone and the radioactivity excretion occurs mostly through the kidneys. Therefore, results from in vitro and in vivo studies indicated good perspectives for this compound to be a potential decorporating agent for hard metal ions in overload situations without depletion of essential metal ions such as zinc.

show abstract

ChemInform Abstract: NEUE KOMPLEXANE 22. MITT. N‐CARBOXYMETHYLIMINOACETHYDROXAM‐ UND IMINODIACETHYDROXAMSAEURE

Karlíček¹,

Majer²

1972

Chemischer Informationsdienst

View full text Add to dashboard Cite

show abstract

Neue Komplexane XXII. N-Carboxymethyliminoacethydroxam- und Iminodiacethydroxamsäure

Cited by 8 publications

References 0 publications

Beyond Biological Chelation: Coordination of f‐Block Elements by Polyhydroxamate Ligands

Beyond Biological Chelation: Coordination of f‐Block Elements by Polyhydroxamate Ligands

A new bis(3-hydroxy-4-pyridinone)-IDA derivative as a potential therapeutic chelating agent. Synthesis, metal-complexation and biological assays

ChemInform Abstract: NEUE KOMPLEXANE 22. MITT. N‐CARBOXYMETHYLIMINOACETHYDROXAM‐ UND IMINODIACETHYDROXAMSAEURE

Contact Info

Product

Resources

About