Neue Bestimmungsmethoden und Bedeutung der Antithrombine für die Klinik

Coagulation Studies in Liver Disease

“…Though the results of investigations of the content of prothrombin, factor VII, factor I X and factor V in the plasma in liver cirrhosis are in good accord, the values reported for AT on this disease vary widely from author to author. Increased or normal values in so-called compensated cirrhosis have been reported by Jurgens (23) and Innerfield et al (22), while other authors have found clearly reduced values in all cases of cirrhosis irrespective whether they are classified as conipensated or decompensated (9, 10. 29, 48).…”

“…I n the evaluation of the results of coagulation studies in liver cirrhosis differences in classification systems used must be borne in mind. It is a common practice to distinguish between hypertrophic and atrophic cirrhosis and between compensated and decompensated cirrhosis (9,22,23). I n our opinion such a distinction is too diffuse to be of practical value.…”

“…I n our inaterial tlie AT content was slightly increased in only one case and norma,l or moderately decreased in the remaining. AT determinations in hepatitis and obstructive jaundice have also given relatively different results (23,29,44,48, and others). I n our cases the value was only slightly increased or decreased (Fig.…”

“…I n 1949 Owren (40) postulated that the formation of factor V is dependent on liver function but not on vitamin K. He claims that a decrease of factor V in hepatitis suggests fairly permanent hepatocellular damage. I n liver cirrhosis the factor V content in the plasma is accordingly low (3,9,11,16,21,23,45,47, and others). There is a fair degree of parallelism between the decrease of factor V and the decrease of the P & P value in the individual case with a certain variation in different investigations.…”

Gerinnungsverhältnisse des Nabelvenenblutes von Frühgeburten und übertragenen Feten

“…Im Zuge unserer Untersuchungen bestimmten wir die in vitro Heparintoleranz nach Murbet und Winterstein [10] die Blutthrom bokinase-Bildung nach der durch Schultze und Schivick modifizierten Biggs-Douglas-McFarlaneschen Methode [2], den Prothrombinspiegel mit dem Zweiphasen-Verfahren nach Rieben-Schultze [14], den Faktor-V-Spiegel nach Oivren [11], den Faktor-VII-Spiegcl m it dem Schnellreagens der Behring-W erke [8], den Fibrinogenspiegel gravimetrisch, das labile Fibrinogen-B nach Curnmin und Lyons [3], den Heparin-Antithrom binspiegel m it der Jürgens-Methode [7], den pro gressiven Antithrombinspiegel m it dem durch Schultze modifizierten Quick-Verfahren [13], den Verbrauch des Kesidualprothrombins im Serum mit der Zweiphasenmethode von Schultze und Schwick [15] sowie die Fibrinolyse mit dem durch Kovdcs [9] …”