Neudesin, A Secretory Protein, Suppresses Cytokine Production in Bone Marrow-Derived Dendritic Cells Stimulated by Lipopolysaccharide
Naoto Kondo,
Yuki Masuda,
Yoshiaki Nakayama
et al.
Abstract:Neudesin was identified as a secretory factor expressed in the nervous system. On the other hand, neudesin is expressed in various organs and cells, suggesting that it plays roles in tissues other than neural tissues. We found that neudesin was expressed in dendritic cells (DCs) in the mouse spleen, which play a crucial role in the initiation of adaptive immune responses. Therefore, considering the possibility that neudesin may affect the acquired immune response, we first investigated whether neudesin has an … Show more
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