NETworking with cancer: The bidirectional interplay between cancer and neutrophil extracellular traps

Adrover, José M.; McDowell, Sheri A C; He, Xueyan; Quail, Daniela F.; Egeblad, Mikala

doi:10.1016/j.ccell.2023.02.001

Cited by 70 publications

(36 citation statements)

References 314 publications

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“…Spleens were also shown as a source of MDSCs in tumor-bearing mice, 58 , 59 but neutrophils undergo further remodeling or reprogramming once they reach the tumors, leading to additional diversity. 1 , 2 , 6 , 16 – 18 , 49 , 50 , 58 , 60 – 66 Colon-infiltrated neutrophils appeared to be less diverse in their RNA expression profiles than tumor-infiltrated neutrophils or even their precursors, the blood neutrophils ( Figures 7C and 7D ). ROS is a key mediator for the immunosuppressive action of MDSCs in the context of tumor immunity.…”

Section: Discussionmentioning

confidence: 99%

Wnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitis

Luan,

Hu,

Wang

et al. 2024

Cell Reports

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Section: Discussionmentioning

confidence: 99%

Wnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitis

Luan,

Hu,

Wang

et al. 2024

Cell Reports

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“…Neutrophils have both pro- and anti-tumor activity 59,60,96 . Consistent with this phenomenon, neutrophil blockade with the Ly6G-specific mAb has no effect on colonic inflammation and colitis 97 .…”

Section: Discussionmentioning

confidence: 99%

PD-L1 Restrains the PD-1^hiNrp1^loTGFβ⁺Treg to block IL6⁺Neutrophil tumor infiltration to Suppress Inflammation-driven Colorectal Cancer

Poschel,

Klement,

Merting

et al. 2023

Preprint

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PD-L1 functions as a suppressor of T cell activation and colonic inflammation. The consequence of and mechanism underlying these opposite functions of PD-L1 in colorectal cancer remains unknown. We report that global Cd274 deletion promotes inflammation-driven colorectal tumorigenesis. 16S rRNA and shotgun metagenomic sequencing revealed that loss of host PD-L1 leads to expansion of gut Ligilactobacillus murinus and activation of the AhR pathway in tumor-bearing mice. scRNA-seq analysis revealed that PD-L1 regulates PD-1hiNrp1lo Treg, IL6+ neutrophils, and B cells in colorectal tumor. Treg expresses high level of TGFβ to recruit IL6+ neutrophils. IL6 inhibits activation of B and T cells. IL6 blockade or B cell activation via CD40 agonist increases CTL activation and suppresses colon tumor growth in vivo. Our findings determine that PD-L1 functions as a tumor suppressor in the context of inflammation-driven colorectal cancer and the PD-L1/L. murius/PD-1hiNrp1loTGFβ+ Treg/IL6+ neutrophils pathway controls host cancer immunosurveillance and colorectal tumorigenesis.

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“…NETosis, a form of programmed cell death initiated by Neutrophil extracellular traps (NETs), represents a distinctive neutrophil death mode [20]. Simply put, the process by which NETs are formed is called NETosis [21]. NETs, composed of DNA and released contents from activated neutrophils, serve as a crucial mechanism for trapping and eliminating bacteria and fungi [22].…”

Section: Disscussionmentioning

confidence: 99%

Prognostic impact and immunotherapeutic implications of NETosis-related prognostic model in clear cell renal cell carcinoma

Mao,

Huang,

Xue

et al. 2024

Preprint

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Background The ramifications of necroptosis on the prognostication of clear cell renal cell carcinoma (ccRCC) remain inadequately expounded. Methods A prognostic model delineating the facets of necroptosis in ccRCC was constructed, employing a compendium of algorithms. External validation was effectuated using the E-MTAB-1980 dataset. The exploration of immune infiltration scores was undertaken through the exploitation of multiple algorithms. Single-gene RNA sequencing data were procured from the GSE171306 dataset. Real-time quantitative PCR (RT-qPCR) was engaged to scrutinize the differential expression of SLC25A37 across cancer and paracancer tissues, as well as diverse cell lines. Assessments of proliferative and metastatic alterations in 769-P and 786-O cells were accomplished through Cell Counting Kit-8 (CCK8) and wound healing assays. Results The necroptosis-related signature (NRS) emerges as a discerning metric, delineating patients' immune attributes, tumor mutation burden, immunotherapy response, and drug susceptibility. Single-gene RNA sequencing analysis unveils the marked enrichment of SLC25A37 in tumor cells. Concurrently, RT-qPCR discloses the overexpression of SLC25A37 in both ccRCC tissues and cell lines. SLC25A37 knockdown mitigates the proliferative and metastatic propensities of 769-P and 786-O cells, as evidenced by CCK8 and wound healing assays. Conclusion The NRS assumes a pivotal role in ascertaining the prognosis, tumor mutation burden, immunotherapy response, drug susceptibility, and immune cell infiltration features of ccRCC patients. SLC25A37 emerges as a putative player in immunosuppressive microenvironments, thereby providing a prospective avenue for the design of innovative immunotherapeutic targets for ccRCC.

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NETworking with cancer: The bidirectional interplay between cancer and neutrophil extracellular traps

Cited by 70 publications

References 314 publications

Wnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitis

Wnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitis

PD-L1 Restrains the PD-1^hiNrp1^loTGFβ⁺Treg to block IL6⁺Neutrophil tumor infiltration to Suppress Inflammation-driven Colorectal Cancer

Prognostic impact and immunotherapeutic implications of NETosis-related prognostic model in clear cell renal cell carcinoma

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NETworking with cancer: The bidirectional interplay between cancer and neutrophil extracellular traps

Cited by 70 publications

References 314 publications

Wnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitis

Wnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitis

PD-L1 Restrains the PD-1hiNrp1loTGFβ+Treg to block IL6+Neutrophil tumor infiltration to Suppress Inflammation-driven Colorectal Cancer

Prognostic impact and immunotherapeutic implications of NETosis-related prognostic model in clear cell renal cell carcinoma

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PD-L1 Restrains the PD-1^hiNrp1^loTGFβ⁺Treg to block IL6⁺Neutrophil tumor infiltration to Suppress Inflammation-driven Colorectal Cancer