Network reset: a simplified overarching theory of locus coeruleus noradrenaline function

Bouret, Sébastien; Sara, Susan J.

doi:10.1016/j.tins.2005.09.002

Cited by 710 publications

(752 citation statements)

References 57 publications

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“…This suggests that LC or neighboring a 1 -receptors may also be involved in nonreward related motor functions or motor coordination. This is in agreement with recent findings that LC neuronal activity is highly correlated with operant response execution in positively motivated tasks (Clayton et al, 2004;Bouret and Sara, 2005). The behavioral activation found in previous studies after stimulation of LC a 1 -receptors may therefore be due to a combination of both motivational and motor effects.…”

Section: Discussionsupporting

confidence: 93%

Role of α1-Adrenoceptors of the Locus Coeruleus in Self-Stimulation of the Medial Forebrain Bundle

Yang

Vaca

Stone

2006

Neuropsychopharmacol

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The present experiments were undertaken to clarify the role of central a 1 -adrenoceptors in reward processes. Rats, trained to selfstimulate via electrodes in the medial forebrain bundle of the lateral hypothalamus, were administered a 1 -selective drugs near the locus coeruleus (LC), a site of a dense concentration of a 1 -receptors. Effects on reward potency were assessed from shifts in rate-frequency curves while effects on motor response capacity were judged from changes in the maximal rates of responding. It was found that local blockade of LC a 1 -receptors with terazosin produced a significant dose-dependent and site-dependent rightward shift of 0.08 log units and a significant decrease of 16.3% in the maximum response rate. Both effects were completely reversed by coadministration of the a 1 -agonist, phenylephrine and were not attributable to terazosin's weak action at a 2 -adrenoceptors. It is concluded that LC a 1 -adrenoceptors are involved both in reward/motivational processes and operant response elaboration which are postulated to work together to facilitate goal attainment. Neuropsychopharmacology (2007) 32, 835-841.

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Section: Discussionsupporting

confidence: 93%

Role of α1-Adrenoceptors of the Locus Coeruleus in Self-Stimulation of the Medial Forebrain Bundle

Yang

Vaca

Stone

2006

Neuropsychopharmacol

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“…We believe that participants' identification of event boundaries corresponds to the resetting of event models when they perform event segmentation tasks. This account is consistent with a recent theory of locus ceruleus norepinephrine function, which proposes that norepinephrine serves as a general reset signal, allowing neural networks to move out of one stable state and settle into a new stable state based on the current network input (Bouret & Sara, 2005). We hypothesize that this reset is approximately hierarchically structured, such that resets of representations with longer timescales are generally a subset of resets of representations with shorter timescales.…”

Section: Perceptual Prediction and Error Detectionsupporting

confidence: 89%

Event perception: A mind-brain perspective.

Zacks¹,

Speer²,

Swallow³

et al. 2007

Psychological Bulletin

876

1,018

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People perceive and conceive of activity in terms of discrete events. Here we propose a theory according to which the perception of boundaries between events arises from ongoing perceptual processing and regulates attention and memory. Perceptual systems continuously make predictions about what will happen next. When transient errors in predictions arise, an event boundary is perceived. According to the theory, the perception of events depends on both sensory cues and knowledge structures that represent previously learned information about event parts and inferences about actors' goals and plans. Neurological and neurophysiological data suggest that representations of events may be implemented by structures in the lateral prefrontal cortex and that perceptual prediction error is calculated and evaluated by a processing pathway including the anterior cingulate cortex and subcortical neuromodulatory systems.

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“…This account is consonant with Bouret and Sara's (2005) view of NE as a neural interrupt signal that promotes learning (see also Bouret & Sara, 2004;David Johnson, 2003): "… these [LC] neurons are activated within behavioral contexts that require a cognitive shift -that is, interruption of ongoing behavior and adaptation. This LC activation occurs whenever there is a change in environmental imperative, such as the appearance of a novel, unexpected event, or a change in stimulus-reinforcement contingencies within a formal learning situation.…”

Section: ) the Relationship Between The P3 And Learningmentioning

confidence: 56%

“…Since the publication of the LC-P3 theory (Nieuwenhuis et al, 2005), researchers have advanced several new accounts that build on the role of phasic LC responses in learning (Bouret & Sara, 2005;Dayan & Yu, 2006;Verguts & Notebaert, 2009). These accounts may enhance our understanding of the P3 literature.…”

Section: ) the Relationship Between The P3 And Learningmentioning

confidence: 99%

Learning, the P3, and the Locus Coeruleus-Norepinephrine System

Nieuwenhuis¹

2011

Neural Basis of Motivational and Cognitive Control

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Network reset: a simplified overarching theory of locus coeruleus noradrenaline function

Cited by 710 publications

References 57 publications

Role of α1-Adrenoceptors of the Locus Coeruleus in Self-Stimulation of the Medial Forebrain Bundle

Role of α1-Adrenoceptors of the Locus Coeruleus in Self-Stimulation of the Medial Forebrain Bundle

Event perception: A mind-brain perspective.

Learning, the P3, and the Locus Coeruleus-Norepinephrine System

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