Network Regulation of the Immune Response to Bacterial Polysaccharide Antigens

Stein, Kathryn E.

doi:10.1007/978-3-642-70675-2_5

Cited by 19 publications

(10 citation statements)

References 75 publications

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“…Therefore, in S. japonicum infection an immunodominant component of the epitope associated with immunoregulation is carbohydrate based. This observation agrees with the previous studies which show a carbohydrate component to the immunodominant epitope of other major cross-reactive idiotypes (Stein 1985). In addition, in parasitic diseases, molecular mimicry of a carbohydrate-containing epitope of Trypanosoma cruzi by anti-idiotypic antibody has been reported (Sacks 1985).…”

Section: Discussionsupporting

confidence: 92%

Characterization of a family of monoclonal antibodies which bind Schistosoma japonicum egg antigens and express an interstrain cross‐reactive idiotype

Olds

Kresina

1990

Parasite Immunology

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A family of monoclonal antibodies (MoAb) was derived from the somatic cell fusion of P3NS1 myeloma cells and lymphoid cells from naturally infected mice of hyperimmunized mice. C57BL/6 mice were naturally infected with Schistosoma japonicum, and BALB/c mice were hyperimmunized with preparations of S. japonicum soluble egg antigens (SEA). The MoAbs which reflected the immune repertoire of naturally infected animals versus hyperimmune animals were characterized with regard to antibody isotype, antigen binding specificity, in-vitro immunosuppression of antigen-induced cell-mediated immune responses and the expression of SJ-CRIM, a major cross-reactive idiotype which appears on polyclonal anti-SEA antibodies generated during murine S. japonicum infection. The data indicate that for MoAbs of the IgG isotype which bound SEA by ELISA, the most immunosuppressive anti-SEA MoAbs identified expressed SJ-CRIM and were derived from naturally infected mice. All anti-SEA MoAbs expressing SJ-CRIM showed an identical banding pattern on immunoblot analysis which was abrogated by weak periodate treatment. The generation of expression of SJ-CRIM on MoAbs using differing methodologies across an allotype barrier indicates that the expression of SJ-CRIM is encoded by a germline gene. These data indicate an association between expression of this germline interstrain cross-reactive idiotype and immunosuppressive capacity. In addition, the immunoregulatory network which develops during immune S. japonicum infection is initiated by a carbohydrate epitope(s) found on various SEA. These data have profound implications in the use of the cross-reactive idiotype as a serodiagnostic tool in schistosomiasis.

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Section: Discussionsupporting

confidence: 92%

Characterization of a family of monoclonal antibodies which bind Schistosoma japonicum egg antigens and express an interstrain cross‐reactive idiotype

Olds

Kresina

1990

Parasite Immunology

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“…For example, neonatal priming using anti-idiotypic reagents renders young animals responsive to otherwise nonimmunogenic bacterial polysaccharides (STEIN 1985). Thus other regulatory mechanisms can clearly operate to expand, and presumably suppress, limited pools of neonatal B lymphocytes bearing antibodies typically encoded by genes expressed at later stages of maturation.…”

Section: Does the Timing Of Vh Gene Expression Explain The Developmenmentioning

confidence: 99%

Programmed Development of the Antibody Repertoire

Perlmutter

1987

Current Topics in Microbiology and Immunology

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“…Ab2^ should be able to induce antigen-specific response in different species. A still expanding number of reports provide evidence for the existence of Ab2â ble to modulate specific immunity in various models of infectious diseases (for reviews see Kennedy 1985, Reagan 1985, Sacks 1985, Stein 1985, Urbain 1985, Green etai. 1985, Ertl&Finberg 1984, McNamara et al 1984, Roehring et al 1985, Grzych et al 1985.…”

Section: Ab2 Against Interspecies Recurrent Idiotopes or Representingmentioning

confidence: 99%