Network Pharmacology Study of Heat‐Clearing and Detoxifying Traditional Chinese Medicine for Alzheimer′s Disease

Abstract

This study aims to explore the possible homologous mechanism of 7 frequently‐used herbs for heat-clearing and detoxification in traditional Chinese medicine (HDTCM) for treating Alzheimer's disease (AD), one of the most common types of dementia, based on network pharmacology. Herbs that satisfied the criteria of containing chlorogenic acid, relating to AD and aligning with HDTCM, were simultaneously collected to determine whether they have anti-AD effect based on a survey of the literature. Herb-ingredient-target-disease networks were constructed by collecting information from the TCMSP and GeneCards public databases. The common targets of the herbs and AD were identified for conducting a Gene Ontology (GO) analyses and a Reactome pathway enrichment analysis. The results showed that PTGS1, IL-6, CASP3, and VEGFA were the predicted key gene targets. The IL-4 and IL-13 signaling pathway, the ESR-mediated signaling pathway, and the extranuclear estrogen signaling pathway were the significant pathways associated with the 7 herbs. This study revealed that the analogous anti-AD mechanism of the 7 herbs of HDTCM may be associated with anti-inflammation, which is a common effect of the chlorogenic acid and quercetin components.

Efficacy and Pharmacological Mechanism of Poria cocos-Based Formulas Combined With Chemotherapy for Ovarian Cancer: A Integrated Systems Pharmacology Study

“…tumulosic acid ((2R)-2-[(3S,5R,10S,13,14,16, 17R)-3,16-dihydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,7,11, 12, 15,16,17-decahydro-1H-cyclopenta [a]phenanthren-17-yl]-6-methyl-5-methylideneheptanoic acid) is a novel, less frequently reported compound with oral bioavailability and drug-like properties of 29.88% and 0.81, respectively. Previous research has established that compounds with oral bioavailability ≥30% and drug-likeness ≥ 0.18 can become effective drugs ( Li L. et al, 2020 ; Li H. et al, 2020 ). Furthermore, based on the molecular docking results, tumulosic acid showed good binding activity to key targets, indicating that acid is likely to be the key active ingredient of Poria cocos against OC.…”

Screening Traditional Chinese Medicine Combination for Co-Treatment of Alzheimer's Disease and Major Depressive Disorder by Network Pharmacology

“…40 Researchers also discovered that suppressing CASP3 expression decreased LPS-induced inflammation in astrocytes associated with neurotic plaques in AD. 41 Furthermore, NOS3 is a nitric oxide synthase (NOS), and studies have shown that the concentration of NOS is higher in patients with depression. 42 Inhibition of NOS3 in the dorsolateral periaqueductal gray matter can play a role in relieving anxiety.…”