Network pharmacology-based study of chinese herbal qixiong formula in treating oligoasthenospermia

Zhao, Feng; Liu, Shengjing; Gao, Qing-He; Zhang, Jiwei; Du, Guan-Chao; Fu, Wang; Guo, Jun

doi:10.4103/wjtcm.wjtcm_75_20

Cited by 13 publications

(14 citation statements)

References 7 publications

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“…This is consistent with the down-regulation of the TCR signaling pathway found in this paper. LTP is the main molecular mechanism underlying learning and memory, and cognitive function and synaptic plasticity are decreased in septic mice ( 24 ). This is consistent with the LTP down-regulation found in this paper.…”

Section: Discussionmentioning

confidence: 99%

Integrated analysis of multi-omics data reveals T cell exhaustion in sepsis

Sun

Zhou³

et al. 2023

Front. Immunol.

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BackgroundSepsis is a heterogeneous disease, therefore the single-gene-based biomarker is not sufficient to fully understand the disease. Higher-level biomarkers need to be explored to identify important pathways related to sepsis and evaluate their clinical significance.MethodsGene Set Enrichment Analysis (GSEA) was used to analyze the sepsis transcriptome to obtain the pathway-level expression. Limma was used to identify differentially expressed pathways. Tumor IMmune Estimation Resource (TIMER) was applied to estimate immune cell abundance. The Spearman correlation coefficient was used to find the relationships between pathways and immune cell abundance. Methylation and single-cell transcriptome data were also employed to identify important pathway genes. Log-rank test was performed to test the prognostic significance of pathways for patient survival probability. DSigDB was used to mine candidate drugs based on pathways. PyMol was used for 3-D structure visualization. LigPlot was used to plot the 2-D pose view for receptor-ligand interaction.ResultsEighty-four KEGG pathways were differentially expressed in sepsis patients compared to healthy controls. Of those, 10 pathways were associated with 28-day survival. Some pathways were significantly correlated with immune cell abundance and five pathways could be used to distinguish between systemic inflammatory response syndrome (SIRS), bacterial sepsis, and viral sepsis with Area Under the Curve (AUC) above 0.80. Seven related drugs were screened using survival-related pathways.ConclusionSepsis-related pathways can be utilized for disease subtyping, diagnosis, prognosis, and drug screening.

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Section: Discussionmentioning

confidence: 99%

Integrated analysis of multi-omics data reveals T cell exhaustion in sepsis

Sun

Zhou³

et al. 2023

Front. Immunol.

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“…SHD is a representative prescription for stroke that recanalizes Fu. It has the effect of harmonizing Qi, blood, and body fluid, cleansing stasis in Fu through which the environment and the internal organs are connected (Zhao and Jie, 2016;Wang Y. et al, 2020 (Dong and Fang, 2005;Gong, 2007). These four herbs have been recorded in ancient books to effectively treat stroke (Song et al, 2016).…”

Section: Composition and Application Of Sanhua Decoctionmentioning

confidence: 99%

Sanhua decoction: Current understanding of a traditional herbal recipe for stroke

et al. 2023

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Both thrombolytic and endovascular therapies are optimal treatment options for patients with acute ischemic stroke, but only less than half of these patients can benefit from these treatments. Traditional Chinese medicine has a long history of successfully managing ischemic stroke using both herbal and physical therapeutics. Among herbal recipes, Sanhua decoction (SHD) is one of the classical prescriptions for ischemic stroke. The present review aimed to summarize evidence from both clinical and basic research to demonstrate its efficacy in managing ischemic stroke and the potential mechanisms underlying its therapeutic effects, which will provide evidence on the therapeutic effect of this herbal recipe and guide future studies on this recipe. SHD is composed of four herbs, Rheum palmatum L. [Polygonaceae], Magnolia officinalis Rehder & E.H.Wilson [Magnoliaceae], Citrus × aurantium L. [Rutaceae], Hansenia weberbaueriana (Fedde ex H.Wolff) Pimenov & Kljuykov [Apiaceae]. We found that the majority of clinical studies on SHD are case reports and they showed positive therapeutic effect of SHD on both acute and chronic ischemic stroke. There are over 40 bioactive compounds identified in SHD, but few experimental studies have examined their individual molecular mechanisms. As an extract of SHD, it improves neurological functions through suppressing inflammation, protecting the blood brain barrier from degradation, restoring the number of neural stem cells, inhibiting apoptosis and brain edema, scavenging oxygen free radicals, and regulating the brain-gut axis. These will lay the theoretical foundation for future studies on this prescription and its clinical application. Future research may need to confirm its clinical efficacy in large-scale clinical trials and to disentangle its bioactive compounds and their potential mechanisms.

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“…[8][9][10] The above-mentioned symptoms which could hardly be explained by "failure of liver to govern the flow of qi" can also be effectively alleviated with the theory of yang stagnation. 11,12 The six stagnations, however, is part of the yang stagnation theory. 13 Guided by Prof. Wanlin Wang, the national famous TCM expert, the research team has been working for many years on benign accumulation patterns in young and middle-aged women and has pointed out that yang stagnation is the basic pathogenesis.…”

Section: Yang Stagnation Is the Basic Pathogenesis Of Benign Accumula...mentioning

confidence: 99%

Treating Benign Accumulation Pattern in Young and Middle-Aged Women According to the Theory of Yang Stagnation

Zhang

Cheng

et al. 2023

Chinese medicine and natural products

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Benign breast nodules, thyroid nodules, and myoma of the uterus are similar in etiology and pathogenesis. These three diseases are classified according to accumulation patterns in traditional Chinese medicine theory and can be treated with the same prescription. Yang stagnation is the basic pathogenesis of benign accumulation patterns in young and middle-aged women. Its treatment principle should be “unblocking yang,” and its treating methods should include diffusing yang, warming yang, dissolving phlegm, and dissipating stasis, which can unblock yang qi and dissolve stasis. Meanwhile, heart-nourishing and mind-calming ingredients should be included in the prescriptions to improve the clinical manifestations.

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Network pharmacology-based study of chinese herbal qixiong formula in treating oligoasthenospermia

Cited by 13 publications

References 7 publications

Integrated analysis of multi-omics data reveals T cell exhaustion in sepsis

Integrated analysis of multi-omics data reveals T cell exhaustion in sepsis

Sanhua decoction: Current understanding of a traditional herbal recipe for stroke

Treating Benign Accumulation Pattern in Young and Middle-Aged Women According to the Theory of Yang Stagnation

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