Network Pharmacology-Based Investigation on Therapeutic Mechanisms of the Angelica dahurica Radix and Ligusticum chuanxiong Rhizoma Herb Pair for Anti-Migraine Effect

Thanh, Chu Duc; Men, Chu Van; Kim, Hyung Min; Kang, Jong Seong

doi:10.3390/plants11172196

Cited by 2 publications

(1 citation statement)

References 89 publications

(96 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Develop an approach of chromatogram similarity analysis to explore the potential biomarkers of DHF for migraine treatment [8].…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology Combined With Chromatogram Similarity Analysis for Biomarkers Exploration of Duliang Herbal Formulation

Chu,

Vu,

Nguyen

et al. 2023

jmpm

View full text Add to dashboard Cite

Objectives: To explore potential biomarkers of the Duliang herbal formula (DHF). Methods: The DHF consisting of a radix of A.dahurica and a rhizome of L. chuanxiong was investigated the pharmacological mechanism for migraine treatment via a network pharmacology approach using published databases and software. Besides, an experimentally chromatographic analysis of DHF was performed to identify potential active components. A combination of two approach results could contribute to propose biomarkers for quality control of DHF. Results: To extend our previous in silico study on anti-migraine compounds in DHF via network pharmacology approach, chromatogram similarity analysis of DHF with different origin herbs had carried out and showed that these active compounds, namely ferulic acid, senkyunolide A, senkyunolide I, ligustilide, byakangelicol, oxypeucedanin, imperatorin, isoimperatorin, and oxypeucedanin hydrate, could be considered as quality markers of formula. Conclusion: Potential biomarkers of DHF for anti-migraine can be explored via an integrated approach using network pharmacology and chromatographic analysis.

show abstract

“…Develop an approach of chromatogram similarity analysis to explore the potential biomarkers of DHF for migraine treatment [8].…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology Combined With Chromatogram Similarity Analysis for Biomarkers Exploration of Duliang Herbal Formulation

Chu,

Vu,

Nguyen

et al. 2023

jmpm

View full text Add to dashboard Cite

show abstract

Potential Targets and Signaling Mechanisms of Cinnamaldehyde Enhancing Intestinal Function and Nutritional Regulation in Fat Greenling (Hexagrammos otakii)

Gu,

Zhan,

Guo

et al. 2024

Aquaculture Nutrition

View full text Add to dashboard Cite

Cinnamaldehyde is an ideal feed additive with good immune enhancement and anti-inflammatory regulation effects. However, the anti-inflammatory regulation mechanism in fat greenling (Hexagrammos otakii, H. otakii) remains unclear. The nine targets of cinnamaldehyde were gathered in identified by the Traditional Chinese Medicine Systems Pharmacology database and Uniprot database, and 1,320 intestinal inflammation disease (IIF)-related proteins were screened from DrugBank, Online Mendelian Inheritance in Man (OMIM), Genecards, and Pharmacogenetics and Pharmacogenomics Knowledge Base (PHARMGKB) Databases. According to the Gene Ontology enrichment results and Kyoto Encyclopedia of Genes and Genomes pathway results, cinnamaldehyde may regulated the responses to bacteria, lipopolysaccharide, an inflammatory cytokine, and external stimuli via the nuclear factor kappa-B (NFκB) signaling pathway within on inflammatory network. In addition, the protein–protein interaction analysis assisted in obtaining the closely related inflammatory regulatory proteins, including the C5a anaphylatoxin chemotactic receptor 1 (C5aR1), transcription factor p65 (RELA), prostaglandin G/H synthase 2 (PTGS2), and toll-like receptor 4 (TLR4), which were confirmed as the bottleneck nodes of the network to be more deeply verified via the molecular docking. Moreover, a cinnamaldehyde feeding model was established for evaluating the anti-inflammatory effect of cinnamaldehyde in vivo. According to the current findings implied that cinnamaldehyde may play a protective role against IIF H. otakii by reducing inflammation through the C5 complement (C5)/C5aR1/interleukin-6 (IL-6) and TLR4/NFκB/PTGS2 pathway. The study focused on investigating the action mechanism of cinnamaldehyde on IIF through combining pharmacology and experimental verification in vivo, which provided a fresh perspective on the promoting effect of cinnamaldehyde on IIF in fish.

show abstract

Network Pharmacology-Based Investigation on Therapeutic Mechanisms of the Angelica dahurica Radix and Ligusticum chuanxiong Rhizoma Herb Pair for Anti-Migraine Effect

Cited by 2 publications

References 89 publications

Network Pharmacology Combined With Chromatogram Similarity Analysis for Biomarkers Exploration of Duliang Herbal Formulation

Network Pharmacology Combined With Chromatogram Similarity Analysis for Biomarkers Exploration of Duliang Herbal Formulation

Potential Targets and Signaling Mechanisms of Cinnamaldehyde Enhancing Intestinal Function and Nutritional Regulation in Fat Greenling (Hexagrammos otakii)

Contact Info

Product

Resources

About