Network pharmacology-based investigation on the mechanisms of action of Morinda officinalis How. in the treatment of osteoporosis

Liu, Zhiwen; Luo, Zhihan; Meng, Qi-Qi; Zhong, Peng-Cheng; Hu, Yingjie; Shen, Xiaoling

doi:10.1016/j.compbiomed.2020.104074

Cited by 35 publications

(26 citation statements)

References 70 publications

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“…Fortunately, with the development of systems biology, systems pharmacology has emerged as an efficient tool to study the mechanism of herbal medicines based on the complex status of the biological system of the human body 13 . For this reason, it has been extensively and successfully used to study the mechanisms of herbal medicine such as Morinda officinalis 14 . In this work, we adopted a standard systems pharmacology approach to screen the compounds that are responsible for the efficacy and toxicity of Fuzi in treating arthritis and inducing toxicity, respectively (Fig.…”

Section: Introductionmentioning

confidence: 99%

Revealing the efficacy-toxicity relationship of Fuzi in treating rheumatoid arthritis by systems pharmacology

Feng

Liu

Zhang

et al. 2021

Sci Rep

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In recent decades, herbal medicines have played more and more important roles in the healthcare system in the world because of the good efficacy. However, with the increasing use of herbal medicines, the toxicity induced by herbal medicines has become a global issue. Therefore, it is needed to investigate the mechanism behind the efficacy and toxicity of herbal medicines. In this study, using Aconiti Lateralis Radix Praeparata (Fuzi) as an example, we adopted a systems pharmacology approach to investigate the mechanism of Fuzi in treating rheumatoid arthritis and in inducing cardiac toxicity and neurotoxicity. The results showed that Fuzi has 25 bioactive compounds that act holistically on 61 targets and 27 pathways to treat rheumatoid arthritis, and modulation of inflammation state is one of the main mechanisms of Fuzi. In addition, the toxicity of Fuzi is linked to 32 compounds that act on 187 targets and 4 pathways, and the targets and pathways can directly modulate the flow of Na+, Ca2+, and K+. We also found out that non-toxic compounds such as myristic acid can act on targets of toxic compounds and therefore may influence the toxicity. The results not only reveal the efficacy and toxicity mechanism of Fuzi, but also add new concept for understanding the toxicity of herbal medicines, i.e., the compounds that are not directly toxic may influence the toxicity as well.

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Section: Introductionmentioning

confidence: 99%

Revealing the efficacy-toxicity relationship of Fuzi in treating rheumatoid arthritis by systems pharmacology

Feng

Liu

Zhang

et al. 2021

Sci Rep

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“…Syndrome-Related Target Screening (TCMID) were applied to collect the chemical ingredients of KD (Wei et al, 2019). Finally, 65 chemical ingredients were obtained, and ingredient-related targets were predicted using Drugbank and SwissTargetprediction databases (Wei et al, 2019;Liu et al, 2020).…”

Section: Kd Chemical Compounds and Metabolicmentioning

confidence: 99%

“…The metabolic syndrome-related targets were screened by Therapeutic Target Database (TTD), Online Mendelian Inheritance in Man (OMIM) and DisGeNET databases (Liu et al, 2020). Eventually, coexistent targets between chemical ingredients and disease were screened as KD-related targets for metabolic syndrome.…”

Section: Kd Chemical Compounds and Metabolicmentioning

confidence: 99%

Kun-Dan Decoction Ameliorates Insulin Resistance by Activating AMPK/mTOR-Mediated Autophagy in High-Fat Diet-Fed Rats

Zeng

Feng

et al. 2021

Front. Pharmacol.

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Background: Metabolic syndrome is characterized by central obesity, hyperglycemia and hyperlipidemia. Insulin resistance is the leading risk factor for metabolic syndrome. Kun-Dan decoction (KD), a traditional Chinese medicine, has been applied to treat patients with metabolic syndrome for over ten years. It is increasingly recognized that autophagy deficiency is the key cause of metabolic syndrome. Therefore, we aimed to explore whether KD can activate autophagy to improve metabolic syndrome.Methods: Network pharmacology was used to explore the underlying mechanism of KD in the treatment of metabolic syndrome. The high-fat diet-fed rats and oleic acid-induced LO2 cells were employed in our study. Oral glucose tolerance test and insulin tolerance test, obesity and histological examination, serum cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), homeostasis model assessment of insulin resistance (HOMA-IR) and insulin sensitivity in high-fat diet-fed rats were analyzed. Furthermore, the protein expressions of adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK), phospho-AMPK, mammalian target of rapamycin (mTOR), phospho-mTOR, p62, autophagy related protein (Atg) 5, Atg7, Atg12, Atg13, Atg16L1 and microtubule-associated protein 1A/1B-light chain 3 (LC3)-Ⅱ/Ⅰ were examined in rats and LO2 cells. Moreover, autophagy activator rapamycin and inhibitor 3-methyladenine, and small interfering RNA against Atg7 were utilized to verify the role of autophagy in the treatment of metabolic syndrome by KD in oleic acid-induced LO2 cells.Results: Results from network pharmacology indicated that targeted insulin resistance might be the critical mechanism of KD in the treatment of metabolic syndrome. We found that KD significantly suppressed obesity, serum cholesterol, triglyceride and LDL-C levels and increased serum HDL-C level in high-fat diet-fed rats. Furthermore, KD enhanced insulin sensitivity and attenuated HOMA-IR in high-fat diet-fed rats. Western blot showed that KD could enhance autophagy to increase the insulin sensitivity of high-fat diet-fed rats and oleic acid-induced LO2 cells. Furthermore, 3-methyladenine and small interfering RNA against Atg7 could reverse the protective effect of KD on LO2 cells. However, rapamycin could cooperate with KD to enhance autophagic activation to increase insulin sensitivity in LO2 cells.Conclusion: The induction of autophagy may be the major mechanism for KD to improve insulin resistance and metabolic syndrome.

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“… 8 In the theoretical system of TCM, OP is defined as bone flaccidity or arthralgia syndrome caused by kidney deficiency. 9 In the treatment of OP, TCM formulas can not only reduce bone loss, but also comprehensively regulate body functions and relieve back pain. Herbal pairs are common clinical TCM formulas, which generally consist of two kinds of herbs.…”

Section: Introductionmentioning

confidence: 99%

Exploring the potential therapeutic effect of Eucommia ulmoides–Dipsaci Radix herbal pair on osteoporosis based on network pharmacology and molecular docking technology

et al. 2022

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Network pharmacology-based investigation on the mechanisms of action of Morinda officinalis How. in the treatment of osteoporosis

Cited by 35 publications

References 70 publications

Revealing the efficacy-toxicity relationship of Fuzi in treating rheumatoid arthritis by systems pharmacology

Revealing the efficacy-toxicity relationship of Fuzi in treating rheumatoid arthritis by systems pharmacology

Kun-Dan Decoction Ameliorates Insulin Resistance by Activating AMPK/mTOR-Mediated Autophagy in High-Fat Diet-Fed Rats

Exploring the potential therapeutic effect of Eucommia ulmoides–Dipsaci Radix herbal pair on osteoporosis based on network pharmacology and molecular docking technology

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