Network pharmacology-based elucidation of bioactive compounds in propolis and putative underlying mechanisms against type-2 diabetes mellitus

Ugwor, Emmanuel Ifeanyichukwu; James, Adewale Segun; Amuzat, Adekunle I.; Ezenandu, Emmanuel O.; Ugbaja, Victory Chukwudalu; Ugbaja, Regina Ngozi

doi:10.1016/j.prmcm.2022.100183

Cited by 2 publications

(3 citation statements)

References 39 publications

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“…Karagecili et al [67] reported that acarbose has less inhibition of A-glucosidase than Turkish propolis. These results are similar to previous reports, which showed inhibition of A-amylase and A-glucosidase in Nigerian propolis [68], propolis from Morocco [69], Turkish propolis [70], and Australian propolis [71], and which concluded that phenolic compounds and mainly flavonoids can inhibit these digestive enzymes, which delays the digestion of carbohydrates and prevents the absorption of glucose, therefore reducing postprandial hyperglycemia.…”

Section: Determination Of Antidiabetic Activity During Digestionsupporting

confidence: 92%

“…[67] reported that acarbose has less inhibition of ɑ-glucosidase than Turkish propolis. These results are similar to previous reports, which showed inhibition of ɑ-amylase and ɑ-glucosidase in Nigerian propolis [68], propolis from Morocco [69], Turkish propolis [70], and Australian propolis [71], and which concluded that phenolic compounds and mainly flavonoids can inhibit these digestive enzymes, which delays the digestion of carbohydrates and prevents the absorption of glucose, therefore reducing postprandial hyperglycemia. All extracts showed antidiabetic activity in the two phases of digestion; in the ɑamylase assay, it was observed that there was a decrease in the gastric phase in the four propolis, followed by an increase in the intestinal phase; on the other hand, when moving from the extract to the intestinal phase, propolis had a decrease from 14 to 33% (Figure 1A).…”

Section: Determination Of Antioxidant Activity During Digestionsupporting

confidence: 92%

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Potential Antidiabetic Activity of Apis mellifera Propolis Extraction Obtained with Ultrasound

Hernández-Martínez,

Zepeda-Bastida,

Morales-Rodríguez

et al. 2024

Foods

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Recent studies have linked phenolic compounds to the inhibition of digestive enzymes. Propolis extract is consumed or applied as a traditional treatment for some diseases. More than 500 chemical compounds have been identified in propolis composition worldwide. This research aimed to determine Mexican propolis extracts’ total phenolic content, total flavonoid content, antioxidant activity, and digestive enzyme inhibitory activity (ɑ-amylase and ɑ-glucosidase). In vitro assays measured the possible effect on bioactive compounds after digestion. Four samples of propolis from different regions of the state of Oaxaca (Mexico) were tested (Eloxochitlán (PE), Teotitlán (PT), San Pedro (PSP), and San Jerónimo (PSJ)). Ethanol extractions were performed using ultrasound. The extract with the highest phenolic content was PE with 15,362.4 ± 225 mg GAE/100 g. Regarding the flavonoid content, the highest amount was found in PT with 8084.6 ± 19 mg QE/100 g. ABTS•+ and DPPH• radicals were evaluated. The extract with the best inhibition concentration was PE with 33,307.1 ± 567 mg ET/100 g. After simulated digestion, phenolics, flavonoids, and antioxidant activity decreased by 96%. In contrast, antidiabetic activity, quantified as inhibition of ɑ-amylase and ɑ-glucosidase, showed a mean decrease in enzyme activity of approximately 50% after the intestinal phase. Therefore, it is concluded that propolis extracts could be a natural alternative for treating diabetes, and it would be necessary to develop a protective mechanism to incorporate them into foods.

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Section: Determination Of Antidiabetic Activity During Digestionsupporting

confidence: 92%

Section: Determination Of Antioxidant Activity During Digestionsupporting

confidence: 92%

Potential Antidiabetic Activity of Apis mellifera Propolis Extraction Obtained with Ultrasound

Hernández-Martínez,

Zepeda-Bastida,

Morales-Rodríguez

et al. 2024

Foods

View full text Add to dashboard Cite

show abstract

“… 24 Some previous studies, using in silico methods such as network pharmacology and molecular docking, have found that Nigerian, Egyptian, and Sulawesi propolis compounds can potentially target neither ERα, HSP90, or other receptors related to anticancer activity. 25 - 27 As propolis composition varies greatly depending on its origin, plant source, bee type, and extraction process, this affects the diversity of propolis biological activity from one another. 28 Therefore, to gain more knowledge and fill the gap in current research, this article will investigate the potential of 93 unique propolis compositions for inhibiting protein receptors of ERα, and HSP90 in breast cancer using in silico approaches.…”

Section: Introductionmentioning

confidence: 99%

Revealing Propolis Potential Activity on Inhibiting Estrogen Receptor and Heat Shock Protein 90 Overexpressed in Breast Cancer by Bioinformatics Approaches

Simanjuntak,

Jauhar,

Syaifie

et al. 2024

Bioinform Biol Insights

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Breast cancer is the most commonly diagnosed cancer globally, with the highest incidence of breast cancer occurring in Asian countries including Indonesia. Among the types of breast cancer, the estrogen receptor (ER)-positive subtype which is prominent with estrogen receptor alpha ( ERα) and heat shock protein 90 ( HSP90) overexpression genes becomes the most prevalent than the others, approximately 75% of all breast cancer cases. ERα and HSP90 play a role in breast cancer activities including breast tumor growth, invasion, and metastasis mechanism. Propolis, a natural bee product, has been explored for its anticancer activity. However, there is lack of studies that evaluated the potential inhibitor from propolis compounds to the ERα and HSP90 proteins. Therefore, this article focuses on examining the correlation between ERα and HSP90’s role in breast cancer and investigating the potential of 93 unique propolis compositions in inhibiting these genes in breast cancer using in silico approaches. This study revealed the positive correlation between ERα and HSP90 genes in breast cancer disease development. Furthermore, we also found novel potential bioactive compounds of propolis against breast cancer through binding with ERα and HSP90; they were 3’,4’,7-trihydroxyisoflavone and baicalein-7-O-β-D glucopyranoside, respectively. Further research on these compounds is needed to elucidate deeper mechanisms and activity in the real biological system to develop new breast cancer drug treatments.

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Network pharmacology-based elucidation of bioactive compounds in propolis and putative underlying mechanisms against type-2 diabetes mellitus

Cited by 2 publications

References 39 publications

Potential Antidiabetic Activity of Apis mellifera Propolis Extraction Obtained with Ultrasound

Potential Antidiabetic Activity of Apis mellifera Propolis Extraction Obtained with Ultrasound

Revealing Propolis Potential Activity on Inhibiting Estrogen Receptor and Heat Shock Protein 90 Overexpressed in Breast Cancer by Bioinformatics Approaches

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