Network pharmacology-based analysis to explore the therapeutic mechanism of Cortex Dictamni on atopic dermatitis

Yang, Niuniu; Shao, Haifeng; Deng, Jialin; Liu, Yanqing

doi:10.1016/j.jep.2022.116023

Cited by 8 publications

(4 citation statements)

References 51 publications

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“…In the network analysis, there were ten core genes, which were ALB, JUN, TP53, AKT1, NFKB1, IL6, SRC, INS, TNF, and BCL2, which are genes with a high degree of closeness centrality and betweenness centrality genes. The genes important to AD disease are Th1 and Th2 cell differentiation [ 56 , 57 , 58 , 59 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Atopic Effect of Scutellaria baicalensis and Raphanus sativus on Atopic Dermatitis-like Lesions in Mice by Experimental Verification and Compound-Target Prediction

Lee,

Seo,

Lee

et al. 2024

Pharmaceuticals

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Scutellaria baicalensis Georgi and Raphanus Sativus Linne herbal mixture (SRE) is a Chinese herbal medicine. In this study, we aimed to evaluate the therapeutic efficacy of SRE as an active ingredient for 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) and to predict the underlying therapeutic mechanisms and involved pathways using network pharmacological analysis. Treatment with SRE accelerated the development of AD-like lesions, improving thickness and edema of the epidermis. Moreover, administering the SRE to AD-like mice suppressed immunoglobulin E and interleukin-4 cytokine and reduced T lymphocyte differentiation. In silico, network analysis was used to predict the exact genes, proteins, and pathways responsible for the therapeutic effect of the SRE against DNCB-induced AD. These results indicated that the SRE exerted protective effects on the DNCB-induced AD-like model by attenuating histopathological changes and suppressing the levels of inflammatory mediators. Therefore, the SRE can potentially be a new remedy for improving AD and other inflammatory diseases and predicting the intracellular signaling pathways and target genes involved. This therapeutic effect of the SRE on AD can be used to treat DNCB-induced AD and its associated symptoms.

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Section: Discussionmentioning

confidence: 99%

Anti-Atopic Effect of Scutellaria baicalensis and Raphanus sativus on Atopic Dermatitis-like Lesions in Mice by Experimental Verification and Compound-Target Prediction

Lee,

Seo,

Lee

et al. 2024

Pharmaceuticals

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show abstract

“…Network pharmacology is an interdisciplinary approach that integrates medicine, pharmacology, network biology, systems biology, and computer science. It exposes complex disease processes, which may be used to generate successful therapeutic approaches based on a thorough understanding of the systems involved [60][61][62][63][64][65][66]. Network pharmacology has been proven to be an effective tool for the acquisition of comprehensive and systematic insights into the polypharmacological properties of herbal medicines, and it is widely employed to investigate the therapeutic targets that are responsible for their pharmacological effects in diverse diseases, such as cancer [67][68][69].…”

Section: Potato Glycoalkaloids and Drug Discoverymentioning

confidence: 99%

Perspective Chapter: Integrated Network Pharmacology and Multiomics Approach to Elucidate the Repositioning of Fatal Food Toxins to Lifesaving Anticancer Drug

A. Badria,

Foda

2024

Poisoning - Prevention, Diagnosis, Treatment and Poison Repurposing

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This research investigates repurposing potato glycoalkaloids as lifesaving anticancer drugs. There is integration of network pharmacology with multiomics. Solanine, chaconine, and their hydrolysis products’ pharmacokinetics were tested using SwissADME. Solanine and chaconine targets were identified via reverse pharmacophore mapping. Through database mining, 26 solanine and chaconine targets were found in cancer genes. To understand gene function, KEGG and GO analyses were done. STRING was used to create a protein-protein interaction network to find similarities between chemicals and cancer. To find prognostic genes in various cancers, CytoHubba in Cytoscape identified hub genes and GEPIA2 did survival analysis. ADME testing for solanine and chaconine medication candidates failed. Their glycosylation boosted solubility and P-glycoprotein inhibition. Cancer targets shared by both drugs were elevated in cancer-related pathways such as Pi3k-Akt1 and HIF-1. Cell death control and programmed cell death genes were enriched in gene ontology study. We built a protein-protein interaction network with 26 nodes and 38 edges. The hub genes were STAT3, TLR4, FGF2, IL2, NFKB1, AR, CHUK, TRIM24, NOS3, and KDM1A. Survival research showed that these genes predict cancer prognosis. We found that solanine and chaconine may interact with cancer-related genes to fight cancer. Discovery of hub genes with prognostic significance sheds light on glycoalkaloids’ anticancer processes.

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“…Genetic studies of UV-irradiated human epidermal cells have revealed that increased inflammatory processes were associated with the upregulation of the JAK/STAT signaling pathway [ 83 ]. AD, also known as atopic eczema, is a common chronic inflammatory skin disease characterized by recurrent, pleomorphic skin lesions; dry skin; and intense itching [ 84 ]. External application of an oligodeoxynucleotide ointment that induces NF-κB activation could improve dermatitis symptoms in the NC/Nga atopic mouse model, indicating that NF-κB deficiency was related to AD pathogenesis [ 85 ].…”

Section: Possible Mechanisms Of Oxidative Stress-induced Skin Cellula...mentioning

confidence: 99%

Possible Mechanisms of Oxidative Stress-Induced Skin Cellular Senescence, Inflammation, and Cancer and the Therapeutic Potential of Plant Polyphenols

Liu

Cheng

Xun

et al. 2023

IJMS

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As the greatest defense organ of the body, the skin is exposed to endogenous and external stressors that produce reactive oxygen species (ROS). When the antioxidant system of the body fails to eliminate ROS, oxidative stress is initiated, which results in skin cellular senescence, inflammation, and cancer. Two main possible mechanisms underlie oxidative stress-induced skin cellular senescence, inflammation, and cancer. One mechanism is that ROS directly degrade biological macromolecules, including proteins, DNA, and lipids, that are essential for cell metabolism, survival, and genetics. Another one is that ROS mediate signaling pathways, such as MAPK, JAK/STAT, PI3K/AKT/mTOR, NF-κB, Nrf2, and SIRT1/FOXO, affecting cytokine release and enzyme expression. As natural antioxidants, plant polyphenols are safe and exhibit a therapeutic potential. We here discuss in detail the therapeutic potential of selected polyphenolic compounds and outline relevant molecular targets. Polyphenols selected here for study according to their structural classification include curcumin, catechins, resveratrol, quercetin, ellagic acid, and procyanidins. Finally, the latest delivery of plant polyphenols to the skin (taking curcumin as an example) and the current status of clinical research are summarized, providing a theoretical foundation for future clinical research and the generation of new pharmaceuticals and cosmetics.

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Network pharmacology-based analysis to explore the therapeutic mechanism of Cortex Dictamni on atopic dermatitis

Cited by 8 publications

References 51 publications

Anti-Atopic Effect of Scutellaria baicalensis and Raphanus sativus on Atopic Dermatitis-like Lesions in Mice by Experimental Verification and Compound-Target Prediction

Anti-Atopic Effect of Scutellaria baicalensis and Raphanus sativus on Atopic Dermatitis-like Lesions in Mice by Experimental Verification and Compound-Target Prediction

Perspective Chapter: Integrated Network Pharmacology and Multiomics Approach to Elucidate the Repositioning of Fatal Food Toxins to Lifesaving Anticancer Drug

Possible Mechanisms of Oxidative Stress-Induced Skin Cellular Senescence, Inflammation, and Cancer and the Therapeutic Potential of Plant Polyphenols

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