2022
DOI: 10.3389/fmolb.2022.847812
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Network Pharmacology and Experimental Validation to Reveal the Pharmacological Mechanisms of Chongcaoyishen Decoction Against Chronic Kidney Disease

Abstract: Objective: To explore the pharmacological mechanisms of Chongcaoyishen decoction (CCYSD) against chronic kidney disease (CKD) via network pharmacology analysis combined with experimental validation.Methods: The bioactive components and potential regulatory targets of CCYSD were extracted from the TCMSP database, and the putative CKD-related target proteins were collected from the GeneCards and OMIM database. We matched the active ingredients with gene targets and conducted regulatory networks through Perl5 and… Show more

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Cited by 8 publications
(3 citation statements)
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“…The TCMSP database ( https://old.tcmsp-e.com/tcmsp.php ) ( Fan et al, 2022 ) was employed to predict the pharmacological targets of ISL (ISL target, iT). A total of 31 iTs were collected.…”
Section: Methodsmentioning
confidence: 99%
“…The TCMSP database ( https://old.tcmsp-e.com/tcmsp.php ) ( Fan et al, 2022 ) was employed to predict the pharmacological targets of ISL (ISL target, iT). A total of 31 iTs were collected.…”
Section: Methodsmentioning
confidence: 99%
“…Using "intervertebral disc degeneration" as the keyword, search results in Genecards ( https://www.genecards.org/ ), Comparative Toxicogenomics Database ( https://ctdbase.org/ ), DisGeNET (https://www.disgenet.org/) disease database to obtain target proteins of the disease [34]. Then, the collected disease target data and differentially regulated genes are intersected to obtain hub gene set A. Intersect the collected disease target data with module genes to obtain hub gene set B.…”
Section: Hub Gene Screeningmentioning
confidence: 99%
“…Molecular pathways mainly include nuclear factor-kappaB (NF-κB) (Wang et al, 2018a), TGF-β1/Smad (Loboda et al, 2016), Notch, winglesstype MMTV integration site (Wnt), Hedgehog (Edeling et al, 2016), protein kinase C (PKC)/extracellular regulated protein kinases (ERK), and PI3K/Akt (Liu et al, 2017), etc. Notably, related studies have shown that the PI3K/Akt signaling pathway can be used as an intervention target in renal fibrosis (Fan et al, 2022;, and also, the PI3K/Akt signaling pathway plays an important regulatory role in the process of cellular autophagy. Autophagy is closely related to renal fibrosis, and a recent study found that sustained activation of autophagy is detrimental to the kidney after severe injury, leading to renal cell senescence and promoting renal fibrosis through the secretion of pro-fibrotic cytokines (Zheng et al, 2019).…”
Section: Introductionmentioning
confidence: 99%