Network memory

Fuster, Joaquı́n M.

doi:10.1016/s0166-2236(97)01128-4

Cited by 533 publications

(393 citation statements)

References 41 publications

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“…Interestingly, in the non-human primate brain, it is well established that there is a functional dichotomy of structures along the anterior-posterior dimension: the posterior cortex appears to specialize in representing sensory information, whereas the frontal lobe is devoted to representing and executing actions. A similar division of labor has been proposed in the human brain (e.g., Fuster, 1997). From this perspective we put forward a question: Is it possible that during event comprehension, graded semantic representations reflecting all prior perceptual experiences and requirements specific to real-world actions are selectively mediated within the posterior and prefrontal cortices, respectively?…”

Section: Two Semantic Neurocognitive Mechanisms Of Comprehension: a Hmentioning

confidence: 59%

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23 Neurocognitive Mechanisms of Human Comprehension

Sitnikova¹,

Holcomb²,

Kuperberg³

2008

Understanding Events

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This chapter begins with a discussion of evidence for distinctions between two semantic comprehension systems in the language domain: a system that maps the perceived information on graded semantic representations and a system that utilizes particular semantic requirements of verbs. It then reviews similar research using static and motion pictures. It argues that the two mechanisms of language comprehension might be analogous to the systems that use graded semantic representations and action-based requirements to make sense of the visual world. The experiments that are reviewed in this chapter examine questions of both how comprehenders understand relationships between the elements within individual events and how they understand the relationships between events. Experiments that have used event-related potentials (ERPs) are also highlighted.

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Section: Two Semantic Neurocognitive Mechanisms Of Comprehension: a Hmentioning

confidence: 59%

“…Rapid reciprocal influences between these processing streams can be mediated by cortico-cortical axons interlinking cortical regions (e.g., Fuster, 1997). Recent ERP data in language comprehension give some evidence for these rapid interactions:…”

Section: Two Semantic Neurocognitive Mechanisms Of Comprehension: a Hmentioning

confidence: 99%

23 Neurocognitive Mechanisms of Human Comprehension

Sitnikova¹,

Holcomb²,

Kuperberg³

2008

Understanding Events

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“…Given the involvement of the mPFC in cognitive functions including the planning and execution of complex tasks (Fuster, 1997), as well as in psychiatric disorders (Drevets et al, 1998), the regulation of 5-HT in this structure may be of special importance. In addition, the present results offer the first demonstration that stressor controllability modulates the subsequent neurochemical response to morphine.…”

Section: Discussionmentioning

confidence: 99%

Stressor Controllability Modulates Stress-Induced Dopamine and Serotonin Efflux and Morphine-Induced Serotonin Efflux in the Medial Prefrontal Cortex

Bland

Hargrave

Pepin

et al. 2003

Neuropsychopharmacol

134

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It has previously been shown that inescapable (IS) but not escapable (ES) stress potentiates the rewarding properties of morphine as measured by conditioned place preference and psychomotor activation, and that this potentiation may be mediated by dorsal raphe nucleus (DRN) serotonin (5-HT) neurons. The medial prefrontal cortex (mPFC) has been implicated in both reward and stress, and is a projection region of the DRN. The mPFC also contains dopaminergic afferents from the ventral tegmental area, which has been the focus of many studies exploring both the rewarding properties of drugs and the aversive properties of stress. The role of the mPFC in stress/ drug reactivity interactions is largely unknown. The present study usedin vivo microdialysis to examine 5-HT and dopamine (DA) efflux in the mPFC of rats during IS, ES or no stress (NS). IS and ES rats received the stressor in yoked pairs. The stressor consisted of tailshocks that could be terminated for both rats by the ES rats. Large increases in 5-HT and DA levels were observed during IS but not ES or NS. DA and 5-HT efflux were also measured 24 h later in the same rats in response to morphine (3 mg/kg) or saline. Sustained increases in 5-HT levels were observed after morphine in rats that had previously received IS but not in rats that had received ES or NS. No changes in DA efflux were observed after morphine. Thus, 5-HT and DA in the mPFC may be involved in stressor controllability effects, and the sensitization of 5-HT neurons by IS extends to the mPFC and to morphine as a challenge.

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“…Pathways linking area 46 with MD, in particular, are active when animals must hold information temporarily in mind to solve the task at hand / 2,48,49,50,53,62 /. The interdependence of prefrontal cortex and MD is exemplified after cooling and incapacitating lateral prefrontal cortex, leading to disruption of activity in MD related to working memory / 2 /.…”

Section: Model Of Prefrontal Influence In Attentional Modulation Thromentioning

confidence: 99%

Circuits for Multisensory Integration and Attentional Modulation Through the Prefrontal Cortex and the Thalamic Reticular Nucleus in Primates

Zikopoulos

Barbas²

2007

Reviews in the Neurosciences

131

111

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Converging evidence from anatomic and physiologic studies suggests that the interaction of highorder association cortices with the thalamus is necessary to focus attention on a task in a complex environment with multiple distractions. Interposed between the thalamus and cortex, the inhibitory thalamic reticular nucleus intercepts and regulates communication between the two structures. Recent findings demonstrate that a unique circuitry links the prefrontal cortex with the reticular nucleus and may underlie the process of selective attention to enhance salient stimuli and suppress irrelevant stimuli in behavior. Unlike other cortices, some prefrontal areas issue widespread projections to the reticular nucleus, extending beyond the frontal sector to the sensory sectors of the nucleus and may influence the flow of sensory information from the thalamus to the cortex. Unlike other thalamic nuclei, the mediodorsal nucleus, which is the principal thalamic nucleus for the prefrontal cortex, has similarly widespread connections with the reticular nucleus. Unlike sensory association cortices, some terminations from prefrontal areas to the reticular nucleus are large, suggesting efficient transfer of information. We propose a model showing that the specialized features of prefrontal pathways in the reticular nucleus may allow selection of relevant information and override distractors, in processes that are deranged in schizophrenia.

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Network memory

Cited by 533 publications

References 41 publications

23 Neurocognitive Mechanisms of Human Comprehension

23 Neurocognitive Mechanisms of Human Comprehension

Stressor Controllability Modulates Stress-Induced Dopamine and Serotonin Efflux and Morphine-Induced Serotonin Efflux in the Medial Prefrontal Cortex

Circuits for Multisensory Integration and Attentional Modulation Through the Prefrontal Cortex and the Thalamic Reticular Nucleus in Primates

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