Network Hyperexcitability in Early-Stage Alzheimer’s Disease: Evaluation of Functional Connectivity Biomarkers in a Computational Disease Model
Cornelis Jan Stam,
Willem de Haan
Abstract:Background: There is increasing evidence from animal and clinical studies that network hyperexcitability (NH) may be an important pathophysiological process and potential target for treatment in early Alzheimer’s disease (AD). Measures of functional connectivity (FC) have been proposed as promising biomarkers for NH, but it is unknown which measure has the highest sensitivity for early-stage changes in the excitation/inhibition balance. Objective: We aim to test the performance of different FC measures in dete… Show more
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