Network Dynamics as an Interface between Modeling and Experiment in Systems Biology

Smith, James M.; Hütt, Marc‐Thorsten

doi:10.1002/9783527630271.ch12

Cited by 4 publications

(2 citation statements)

References 146 publications

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“…Contributions from Physics can be expected to play a decisive role along the way. 2 This example goes back to a review by Orly Alter [149]; see also [150].…”

Section: Discussionmentioning

confidence: 99%

The Physics behind Systems Biology

Radde

Hütt

2016

EPJ Nonlinear Biomed Phys

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Systems Biology is a young and rapidly evolving research field, which combines experimental techniques and mathematical modeling in order to achieve a mechanistic understanding of processes underlying the regulation and evolution of living systems. Systems Biology is often associated with an Engineering approach: The purpose is to formulate a data-rich, detailed simulation model that allows to perform numerical ('in silico') experiments and then draw conclusions about the biological system. While methods from Engineering may be an appropriate approach to extending the scope of biological investigations to experimentally inaccessible realms and to supporting data-rich experimental work, it may not be the best strategy in a search for design principles of biological systems and the fundamental laws underlying Biology. Physics has a long tradition of characterizing and understanding emergent collective behaviors in systems of interacting units and searching for universal laws. Therefore, it is natural that many concepts used in Systems Biology have their roots in Physics. With an emphasis on Theoretical Physics, we will here review the 'Physics core' of Systems Biology, show how some success stories in Systems Biology can be traced back to concepts developed in Physics, and discuss how Systems Biology can further benefit from its Theoretical Physics foundation.

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“…Contributions from Physics can be expected to play a decisive role along the way. 2 This example goes back to a review by Orly Alter [149]; see also [150].…”

Section: Discussionmentioning

confidence: 99%

The Physics behind Systems Biology

Radde

Hütt

2016

EPJ Nonlinear Biomed Phys

Self Cite

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“…In its simplest form, systems biology is the systemic contextualization of large numbers of individual observations (see, e.g. Smith and Hütt 2010;Hütt 2014). At the core of systems-thinking in biology is the concept of networks (Barabási and Oltvai 2004;Gallos et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Rhythms in Plants

Mancuso¹,

Shabala²

2015

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Systems Biology in Psychiatric Research: From Complex Data Sets Over Wiring Diagrams to Computer Simulations

Tretter

Gebicke‐Haerter

2011

Methods in Molecular Biology

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The classification of psychiatric disorders has always been a problem in clinical settings. The present debate about the major systems in clinical practice, DSM-IV and ICD-10, has resulted in attempts to improve and replace those schemes by some that include more endophenotypic and molecular features. However, these disorders not only require more precise diagnostic tools, but also have to be viewed more extensively in their dynamic behaviors, which require more precise data sets related to their origins and developments. This enormous challenge in brain research has to be approached on different levels of the biological system by new methods, including improvements in electroencephalography, brain imaging, and molecular biology. All these methods entail accumulations of large data sets that become more and more difficult to interpret. In particular, on the molecular level, there is an apparent need to use highly sophisticated computer programs to tackle these problems. Evidently, only interdisciplinary work among mathematicians, physicists, biologists, and clinicians can further improve our understanding of complex diseases of the brain.

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Network Dynamics as an Interface between Modeling and Experiment in Systems Biology

Cited by 4 publications

References 146 publications

The Physics behind Systems Biology

The Physics behind Systems Biology

Rhythms in Plants

Systems Biology in Psychiatric Research: From Complex Data Sets Over Wiring Diagrams to Computer Simulations

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