“…Regardless of these differences, we can still look to models of P23H rhodopsin for future investigation. It is possible that cones regulate expression of misfolded cone opsin through similar pathways as rods regulate P23H rhodopsin, with previous studies demonstrating that Rho P23H mRNA is degraded through mRNA decay and ribosome quality control, while translated P23H rhodopsin is degraded through ER-associated degradation (36,46). Another possibility is that mutant mRNA is subjected to miRNA-mediated decay, as previous studies have shown that miRNAs play a crucial role in photoreceptor homeostasis, function, and survival (47).…”