Network-based prioritization and validation of regulators of vascular smooth muscle cell proliferation in disease
Jordi Lambert,
Sebnem Oc,
Matthew D. Worssam
et al.
Abstract:Aberrant vascular smooth muscle cell (VSMC) homeostasis and proliferation characterize vascular diseases causing heart attack and stroke. Here we elucidate molecular determinants governing VSMC proliferation by reconstructing gene regulatory networks from single-cell transcriptomics and epigenetic profiling. We detect widespread activation of enhancers at disease-relevant loci in proliferation-predisposed VSMCs. We compared gene regulatory network rewiring between injury-responsive and nonresponsive VSMCs, whi… Show more
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