Network-based fMRI-neurofeedback training of sustained attention

Pamplona, Gustavo Santo Pedro; Heldner, Jennifer; Langner, Robert; Koush, Yury; Michels, Lars; Ionta, Silvio; Scharnowski, Frank; Salmon, Carlos Ernesto Garrido

doi:10.1016/j.neuroimage.2020.117194

Cited by 49 publications

(76 citation statements)

References 88 publications

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“…Unlike Scharnowski and colleagues (2015), however, we focus on the balance between two large-scale brain networks that each consist of multiple brain areas and are functionally related. Our approach is in line with two other recent neurofeedback studies that target large-scale brain network balance (Kim et al 2019;Pamplona et al, 2020). While Kim and colleagues (2019) targeted changes in functional connectivity between SN and DMN, Pamplona and colleagues (2020) took an approach similar to ours and targeted the difference in the activation between the sustained attention network and DMN.…”

Section: Discussionsupporting

confidence: 66%

Self-regulation of stress-related large-scale brain network balance using real-time fMRI Neurofeedback

Krause

Kogias

Krentz

et al. 2021

Preprint

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It has recently been shown that acute stress affects the allocation of neural resources between large-scale brain networks, and the balance between the executive control network and the salience network in particular. Maladaptation of this dynamic resource reallocation process is thought to play a major role in stress-related psychopathology, suggesting that stress resilience may be determined by the retained ability to adaptively reallocate neural resources between these two networks. Actively training this ability could hence be a potentially promising way to increase resilience in individuals at risk for developing stress-related symptomatology. Using real-time functional Magnetic Resonance Imaging, the current study investigated whether individuals can learn to self-regulate stress-related large-scale network balance. Participants were engaged in a bidirectional and implicit real-time fMRI neurofeedback paradigm in which they were intermittently provided with a visual representation of the difference signal between the average activation of the salience and executive control networks, and tasked with attempting to self-regulate this signal. Our results show that, given feedback about their performance over three training sessions, participants were able to (1) learn strategies to differentially control the balance between SN and ECN activation on demand, as well as (2) successfully transfer this newly learned skill to a situation where they (a) did not receive any feedback anymore, and (b) were exposed to an acute stressor in form of the prospect of a mild electric stimulation. The current study hence constitutes an important first successful demonstration of neurofeedback training based on stress-related large-scale network balance - a novel approach that has the potential to train control over the central response to stressors in real-life and could build the foundation for future clinical interventions that aim at increasing resilience.

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Section: Discussionsupporting

confidence: 66%

Self-regulation of stress-related large-scale brain network balance using real-time fMRI Neurofeedback

Krause

Kogias

Krentz

et al. 2021

Preprint

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“…Among the scarce literature on interoceptive awareness and brain imaging 51 – 53 , a recent study reported self-regulated sustained attention by modulating the interaction between the salience and the default mode networks 54 . Such studies reinforce the approach that mind, cognition and emotion emerge from the reciprocal interactions of the brain-body signals-external world.…”

Section: Discussionmentioning

confidence: 99%

Brain connectivity dynamics in cisgender and transmen people with gender incongruence before gender affirmative hormone treatment

Uribe

Junqué

Gómez‐Gil

et al. 2021

Sci Rep

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Large-scale brain network interactions have been described between trans- and cis-gender binary identities. However, a temporal perspective of the brain's spontaneous fluctuations is missing. We investigated the functional connectivity dynamics in transmen with gender incongruence and its relationship with interoceptive awareness. We describe four states in native and meta-state spaces: (i) one state highly prevalent with sparse overall connections; (ii) a second with strong couplings mainly involving components of the salience, default, and executive control networks. Two states with global sparse connectivity but positive couplings (iii) within the sensorimotor network, and (iv) between salience network regions. Transmen had more dynamical fluidity than cismen, while cismen presented less meta-state fluidity and range dynamism than transmen and ciswomen. A positive association between attention regulation and fluidity and meta-state range dynamism was found in transmen. There exist gender differences in the temporal brain dynamism, characterized by distinct interrelations of the salience network as catalyst interacting with other networks. We offer a functional explanation from the neurodevelopmental cortical hypothesis of a gendered-self.

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“…These findings were echoed by Provazza and colleagues demonstrating a similar visual processing challenge in this population ( Provazza et al, 2019 ). Considering the brain networks involved, for example, in visuospatial processing ( Perruchoud et al, 2016 ) or attention ( Pamplona et al, 2020 ) comprise a large number of brain regions and related interconnections both in adulthood and development ( Ionta, 2021 ), it is possible that in individuals with dyslexia, possibly over time/age, natural neuroplastic compensatory mechanisms are put in place to establish alternative neural activations/connections which would make dyslectic people able to compensate their deficits and resemble the performance of their age-matched non-dyslectic peers in the domains of organization, visual-spatial abilities, shifting, and attention.…”

Section: Resultsmentioning

confidence: 99%

Neuro-Behavioral Correlates of Executive Dysfunctions in Dyslexia Over Development From Childhood to Adulthood

2021

Self Cite

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Dyslexia is a neurobiological learning disability in the reading domain that has symptoms in early childhood and persists throughout life. Individuals with dyslexia experience difficulties in academia and cognitive and emotional challenges that can affect wellbeing. Early intervention is critical to minimize the long-term difficulties of these individuals. However, the behavioral and neural correlates which predict dyslexia are challenging to depict before reading is acquired. One of the precursors for language and reading acquisition is executive functions (EF). The present review aims to highlight the current atypicality found in individuals with dyslexia in the domain of EF using behavioral measures, brain mapping, functional connectivity, and diffusion tensor imaging along development. Individuals with dyslexia show EF abnormalities in both behavioral and neurobiological domains, starting in early childhood that persist into adulthood. EF impairment precedes reading disability, therefore adding an EF assessment to the neuropsychological testing is recommended for early intervention. EF training should also be considered for the most comprehensive outcomes.

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Network-based fMRI-neurofeedback training of sustained attention

Cited by 49 publications

References 88 publications

Self-regulation of stress-related large-scale brain network balance using real-time fMRI Neurofeedback

Self-regulation of stress-related large-scale brain network balance using real-time fMRI Neurofeedback

Brain connectivity dynamics in cisgender and transmen people with gender incongruence before gender affirmative hormone treatment

Neuro-Behavioral Correlates of Executive Dysfunctions in Dyslexia Over Development From Childhood to Adulthood

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