Network-Based Analysis Reveals Association of FOXE1 Gene Polymorphisms in Thyroid Cancer Patients; A Case-Control Study in Southeast of Iran

Histopathologic patterns of intracranial neoplasms at Lagos University Teaching Hospital, Nigeria. A ten-year hospital-based retrospective study

“…This study also shows that lymphomas and tumors of the cranial nerves including schwannoma are uncommon in our environment unlike other parts of the world. 8 , 9 , 12 , 13 , 15 Similar observation was made by Ndubuisi et al 21 …”

“…These findings are similar to that of Malami 23 This study also shows that lymphomas and tumors of the cranial nerves including schwannoma are uncommon in our environment unlike other parts of the world. 8,9,12,13,15 Similar observation was made by Ndubuisi et al 21 Result of most studies, including those done in Nigeria and globally, showed equal rate of occurrence of intracranial tumors in both genders or a slight male preponderance; many reported a male to female ratio of 1:1. 6,7,14,18,19,20,21,22 However, our study showed a slight female preponderance in the rate of occurrence of intracranial tumors with male to female ratio of 1:1.3.…”

“…17,18,20,22 (Table 2) This is in contrast with the global reports, especially from the Western world and Asia, in that both meningioma and gliomas remain relatively more common than pituitary adenomas (Table1). [6][7][8][9][10][11][12][13][14][15][16] Potential etiological factors to explain this geographical difference, including genetic predisposition, infectious agents, radiation, etc., requires investigation. 5 The discrepancy in the pattern of occurrence of ICTs in Nigeria when compared with Caucasians may also be attributed to the poor availability of quality health services and poor health seeking behaviour of its citizens, as most people in Nigeria seek for treatment only when there are complications.…”

“…5 The global pattern of intracranial tumors is as shown in Table 1, and it depicts meningioma and glioma as the two commonest ICT and pituitary adenoma as the 3rd most common ICT globally. [6][7][8][9][10][11][12][13][14][15][16] Few studies have been conducted in Nigeria to demonstrate the pattern of occurrence, age, and sex distributions of these intracranial neoplasms. The result of most of these studies carried out in Nigeria still showed meningioma as the commonest ICT.…”

The Role of Genetic Polymorphisms in Differentiated Thyroid Cancer: A 2023 Update

“…However, the previously mentioned study was conducted mainly on Caucasians, with a small sample of Asian studies. Recently, a case-control study conducted in Iran on 81 patients with thyroid cancer and 165 controls found that FOXE1 polymorphism (rs1867277) could be used as a biomarker for thyroid cancer diagnosis, being found in 32.1% (homozygous GG) and 18.5% (homozygous AA) of thyroid cancer patients [ 69 ].…”