Network Analysis to Identify Communities Among Multiple Exposure Biomarkers Measured at Birth in Three Flemish General Population Samples

Ottenbros, Ilse; Govarts, Eva; Lebret, Erik; Vermeulen, Roel; Schoeters, Greet; Vlaanderen, Jelle

doi:10.3389/fpubh.2021.590038

Cited by 13 publications

(13 citation statements)

References 42 publications

(28 reference statements)

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“…A monitoring study by Zheng et al showed that PFAS are routinely detected in breast milk in the United States, demonstrating the scope of this potential concern [ 83 ]. Beyond lactation, numerous recent studies have shown that PFAS are frequently detected in cord blood samples, indicating that there is ubiquitous fetal exposure to PFAS globally [ 84 , 85 , 86 , 87 , 88 , 89 ]. Though the majority of the studies included in this scoping review focused upon adults, more studies are needed to elucidate whether these fetal and infant exposures may increase risk for diabetes in children.…”

Section: Discussionmentioning

confidence: 99%

Associations between Exposures to Perfluoroalkyl Substances and Diabetes, Hyperglycemia, or Insulin Resistance: A Scoping Review

Margolis

Sant

2021

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Per- and polyfluoroalkyl substances (PFASs) are persistent environmental pollutants that are commonly found in the human body due to exposures via drinking water, surfactants used in consumer materials, and aqueous film-forming foams (AFFFs). PFAS exposure has been linked to adverse health effects such as low infant birth weights, cancer, and endocrine disruption, though increasingly studies have demonstrated that they may perturb metabolic processes and contribute to dysfunction. This scoping review summarizes the chemistry of PFAS exposure and the epidemiologic evidence for associations between exposure to per- and polyfluoroalkyl substances and the development of diabetes, hyperglycemia, and/or insulin resistance. We identified 11 studies on gestational diabetes mellitus, 3 studies on type 1 diabetes, 7 studies on type 2 diabetes, 6 studies on prediabetes or unspecified diabetes, and 15 studies on insulin resistance or glucose tolerance using the SCOPUS and PubMed databases. Approximately 24 reported positive associations, 9 negative associations, 2 non-linear associations, and 2 inverse associations, and 8 reported no associations found between PFAS and all diabetes search terms. Cumulatively, these data indicate the need for further studies to better assess these associations between PFAS exposure and diabetes.

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Section: Discussionmentioning

confidence: 99%

Associations between Exposures to Perfluoroalkyl Substances and Diabetes, Hyperglycemia, or Insulin Resistance: A Scoping Review

Margolis

Sant

2021

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“…Presentation of modelled exposure or HBM data in networks facilitates the detection of exposure patterns and allows for the systematic comparison of observed exposure patterns between datasets and strata within datasets (Ottenbros, Govarts et al 2021). The identification of groups of highly connected biomarkers, "communities," within these networks highlighted which biomarkers should be considered collectively in the analysis and interpretation of epidemiological studies or in the design of toxicological mixture studies.…”

Section: Statistical Methods Identifying Co-exposure Patternsmentioning

confidence: 99%

“…Presentation of biomonitoring data in networks facilitates the detection of exposure patterns and allows for the systematic comparison of observed exposure patterns between datasets and strata within datasets (Ottenbros, Govarts et al 2021). The use of network techniques in human biomonitoring data, from cord blood samples collected in three campaigns of the Flemish Environment and Health Studies (FLEHS) (sampling years resp.…”

Section: Statistical Tools To Analyse Mixture Exposure At the Individ...mentioning

confidence: 99%

Roadmap for action on Risk Assessment of Combined Exposure to Multiple Chemicals (RACEMiC)

Jong

Voet

Marx‐Stoelting

et al. 2022

EFSA Supporting Publications

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EFSA's aim by 2030, is that the Agency and its partners will be equipped for the routine implementation of human health risk assessment to multiple chemicals, across EFSA's domains of activity. To facilitate this effort, a roadmap for action has been developed by mapping the methods, data and tools that are currently available for mixture risk assessment and identifying current scientific gaps including challenges and blockers. The results shows that extensive methods, data and tools are available for dietary mixture risk assessment for pesticides, but that several scientific gaps still exist for the non‐dietary mixture exposure to pesticides. For food additives and for certain contaminants, the regulatory readiness for mixture risk assessment was also found to be fairly high compared to food contact materials and cross‐silo mixture risk assessment. The scientific gaps identified were prioritised according to their impact on the implementation of mixture risk assessment and, as a result, ten multi‐annual project proposals were defined to address these scientific gaps on the short‐term, mid‐term and long‐term. The roadmap also proposes and prioritises a number of working areas in the regulatory domains of pesticides, food contact materials, contaminants, food additives, as well as in the overarching domain of chemicals. Besides the scientific proposals, recommendations to improve stakeholder engagement and communication on mixture risk assessment was investigated. These included, among others, creating an online catalogue of tools, methods and data for mixture risk assessment, as well as the organisation of regular webinars/workshop to promote exchange of information between stakeholders and making more efficient use of national communication hubs for food safety in communicating with the general public.

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“…PFAS in FLEHS I were measured in 15-year stored biobank samples by ultra-performance liquid chromatographytandem mass spectrometry (UPLC-MS/MS) using Waters Acquity UPLC H-class system (Waters, Milford, MA, USA). POP concentrations which were lower than the LOQs were singly imputed per cohort using maximum likelihood estimation, assuming a censored log-normal distribution for values over the LOQ conditional on the observed values for other biomarkers (Lubin et al, 2004;Ottenbros et al, 2021). Considering that the concentrations of lipophilic biomarkers vary depending on lipid levels, the concentrations of OCs after lipid standardization was calculated and expressed in ng/g lipid for subsequent analyses.…”

Section: 2mentioning

confidence: 99%

Prenatal exposure to persistent organic pollutants and changes in infant growth and childhood growth trajectories

Cai

Portengen

Govarts

et al. 2022

Preprint

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BackgroundChildren are born with a burden of persistent organic pollutants (POPs) which may have endocrine disrupting properties and have been postulated to contribute to the rise in childhood obesity. The current evidence is equivocal, which may be because many studies investigate the effects at one time point during childhood. We assessed associations between prenatal exposure to POPs and growth during infancy and childhood.MethodsWe used data from two Belgian cohorts with cord blood measurements of five organochlorines [(dichlorodiphenyldichloroethylene (p,p’-DDE), hexachlorobenzene (HCB), polychlorinated biphenyls (PCB-138, -150, -180)] (N = 1,418) and two perfluoroalkyl substances [perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS)] (N = 346). We assessed infant growth, defined as body mass index (BMI) z-score change between birth and 2 years, and childhood growth, characterized as BMI trajectory from birth to 8 years. To evaluate associations between POP exposures and infant growth, we applied a multi-pollutant approach, using penalized elastic net regression with stability selection, controlling for covariates. To evaluate associations with childhood growth, we used single-pollutant linear mixed models with random effects for child individual, parametrized using a natural cubic spline formulation.ResultsPrenatal exposures to p,p’-DDE and PCB-153 were selected in elastic net models for infant growth analysis, but the selections were unstable. No clear association between any of the exposures and longer-term childhood growth trajectories was observed. We did not find evidence of effect modification by child sex.ConclusionOur results suggest that prenatal exposure to PCB-153 and p,p’-DDE may affect infant growth in the first two years, with little evidence of more persistent effects.

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Network Analysis to Identify Communities Among Multiple Exposure Biomarkers Measured at Birth in Three Flemish General Population Samples

Cited by 13 publications

References 42 publications

Associations between Exposures to Perfluoroalkyl Substances and Diabetes, Hyperglycemia, or Insulin Resistance: A Scoping Review

Associations between Exposures to Perfluoroalkyl Substances and Diabetes, Hyperglycemia, or Insulin Resistance: A Scoping Review

Roadmap for action on Risk Assessment of Combined Exposure to Multiple Chemicals (RACEMiC)

Prenatal exposure to persistent organic pollutants and changes in infant growth and childhood growth trajectories

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