Network Analysis of Acupuncture Points Used in the Treatment of Low Back Pain

Lee, Soon Ho; Kim, Chang Eop; Lee, In Seon; Jung, Won Jai; Kim, Hong Gee; Jang, Hyunchul; Kim, Sang Jeong; Lee, Hyejung; Park, Hi-Joon; Chae, Younbyoung

doi:10.1155/2013/402180

Cited by 39 publications

(27 citation statements)

References 17 publications

(19 reference statements)

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“…Furthermore, we hypothesize that local acupuncture inhibited the dental noxious stimuli avoiding a consecutive trigeminal neural signaling, which can be explained by the gate control theory [16,19]. Therefore, there is a need for a new approach into the acupoint selection underlying the treatment for a better understanding of it therapeutic benefits [28].…”

Section: Behavioral Measurements In the Dpi Modelmentioning

confidence: 95%

“…As in previous research, the sham acupoints were located in the middle of the lateral deltoid muscle, in a region distant from most meridians [27]. The selection of acupoints was based on two of a total of three principles that are used commonly by practitioners indicating that: local acupoints selection (near the symptoms area), distant acupoints selection (along the meridian) and also based on symptom differentiation [28]. Likewise, the mice trans-positional acupoint system was followed, as previously described [52], ( Figure S1).…”

Section: Verum (Local and Distal) And Sham Ea Groupsmentioning

confidence: 99%

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Analgesic and Neuroprotective Effects of Electroacupuncture in a Dental Pulp Injury Model—A Basic Research

Romero

Lee

Fuh

et al. 2020

IJMS

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Irreversible pulpitis is an extremely painful condition and its consequence in the central nervous system (CNS) remains unclear. A mouse model of dental pulp injury (DPI) resembles the irreversible pulpitis profile in humans. This study sought to determine whether pain induced by DPI activates microglia and astrocytes in the trigeminal subnucleus caudalis (Vc), as well as increases levels of proinflammatory cytokines, and whether electroacupuncture (EA) can be a potential analgesic and neuroprotective therapy following DPI. Pain behavior was measured via head-withdrawal threshold (HWT) and burrowing behavior at days 1, 3, 7, 14 and 21 after DPI. A marked decrease in HWT and burrowing activity was observed from day 1 to 14 after DPI and no changes were seen on day 21. Microglial and astrocytes activation; along with high cytokine (TNFα, IL-1β, and IL-6) levels, were observed in the Vc at 21 days after DPI. These effects were attenuated by verum (local and distal) EA, as well as oral ibuprofen administration. The results suggest that DPI-induced pain and glial activations in the Vc and EA exert analgesic efficacy at both local and distal acupoints. Furthermore, verum (local and distal) EA might be associated with the modulations of microglial and astrocytes activation.

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Section: Behavioral Measurements In the Dpi Modelmentioning

confidence: 95%

Section: Verum (Local and Distal) And Sham Ea Groupsmentioning

confidence: 99%

Analgesic and Neuroprotective Effects of Electroacupuncture in a Dental Pulp Injury Model—A Basic Research

Romero

Lee

Fuh

et al. 2020

IJMS

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“…The study was improved with the research of Lee et al [32] that clarified which acupoints are frequently used together to treat Low Back Pain.…”

Section: Graph Theory In Connectomicsmentioning

confidence: 99%

ConnectViz: Accelerated Approach for Brain Structural Connectivity Using Delaunay Triangulation

Adeshina

Hashim

2015

Interdiscip Sci Comput Life Sci

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Stroke is a cardiovascular disease with high mortality and long-term disability in the world. Normal functioning of the brain is dependent on the adequate supply of oxygen and nutrients to the brain complex network through the blood vessels. Stroke, occasionally a hemorrhagic stroke, ischemia or other blood vessel dysfunctions can affect patients during a cerebrovascular incident. Structurally, the left and the right carotid arteries, and the right and the left vertebral arteries are responsible for supplying blood to the brain, scalp and the face. However, a number of impairment in the function of the frontal lobes may occur as a result of any decrease in the flow of the blood through one of the internal carotid arteries. Such impairment commonly results in numbness, weakness or paralysis. Recently, the concepts of brain's wiring representation, the connectome, was introduced. However, construction and visualization of such brain network requires tremendous computation. Consequently, previously proposed approaches have been identified with common problems of high memory consumption and slow execution. Furthermore, interactivity in the previously proposed frameworks for brain network is also an outstanding issue. This study proposes an accelerated approach for brain connectomic visualization based on graph theory paradigm using compute unified device architecture, extending the previously proposed SurLens Visualization and computer aided hepatocellular carcinoma frameworks. The accelerated brain structural connectivity framework was evaluated with stripped brain datasets from the Department of Surgery, University of North Carolina, Chapel Hill, USA. Significantly, our proposed framework is able to generate and extract points and edges of datasets, displays nodes and edges in the datasets in form of a network and clearly maps data volume to the corresponding brain surface. Moreover, with the framework, surfaces of the dataset were simultaneously displayed with the nodes and the edges. The framework is very efficient in providing greater interactivity as a way of representing the nodes and the edges intuitively, all achieved at a considerably interactive speed for instantaneous mapping of the datasets' features. Uniquely, the connectomic algorithm performed remarkably fast with normal hardware requirement specifications.

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“…[1][2][3][4] Acupuncture points are generally located along these meridians and, when stimulated, are thought to restore normal circulation of qi to achieve balance and cure disease. [5][6][7][8] Acupuncture holds a long history in China, where it continues to be regularly used independently and as an adjunct to modern medicine to treat a broad range of diseases, including dermatologic disorders. Over the past few decades, the interest in acupuncture has expanded to other countries, including the United States, because of the growing popularity of complementary and alternative medicine (CAM).…”

Section: Introductionmentioning

confidence: 99%