Network analysis for elucidating the mechanisms of Shenfu injection in preventing and treating COVID-19 combined with heart failure

Zhou, Wei; Chen, Ziyi; Zheng, Fang; Xu, Damo

doi:10.1016/j.compbiomed.2022.105845

Cited by 5 publications

(1 citation statement)

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“…It originated from the traditional Chinese classical formula “Shenfu Decoction", which was first recorded in Yan’s Prescriptions for Rescuing Lives in the Song Dynasty (1253 AD). SFI is composed of Panax ginseng C.A.Mey [Araliaceae; Ginseng radix et rhizoma rubra] (RG) ( Figure 2 ) and Aconitum carmichaelii Debx [Ranunculaceae; Aconiti lateralis radix praeparata] (RA) ( Figure 3 ), which has the function of restoring Yang and invigorating Qi ( Pei et al, 2021 ; Zhou et al, 2022 ). The existing studies reported that RG can be used to treat coronary heart disease and atherosclerosis by reducing blood lipid levels and improving inflammation ( Hernández-García et al, 2019 ; Lu et al, 2019 ; Im, 2020 ).…”

Section: Sfi -Basic Characteristics and History Of Usementioning

confidence: 99%

Shenfu injection: a review of pharmacological effects on cardiovascular diseases

Xu,

Xie,

et al. 2024

Front. Pharmacol.

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Shenfu injection (SFI), composed of ginseng and aconite, is a Chinese patent developed from the classic traditional prescription Shenfu Decoction created more than 700 years ago. SFI has been widely used in China for over 30 years for treating cardiovascular diseases. The main components in it include ginsenosides and aconitum alkaloids. In recent years, the role of SFI in the treatment of cardiovascular diseases has attracted much attention. The pharmacological effects and therapeutic applications of SFI in cardiovascular diseases are summarized here, highlighting pharmacological features and potential mechanisms developments, confirming that SFI can play a role in multiple ways and is a promising drug for treating cardiovascular diseases.

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