Network analysis combined with pharmacological evaluation strategy to reveal the mechanism of Tibetan medicine Wuwei Shexiang pills in treating rheumatoid arthritis
Abstract:Tibetan medicine is an important part of traditional Chinese medicine and a significant representative of ethnic medicine in China. Tibetan medicine is gradually recognized by the world for its unique curative effects. Wuwei Shexiang pills (WPW) has been widely used to treat “Zhenbu” disease (Also known as rheumatoid arthritis) in Tibetan medicine, however, its potential bioactive ingredients and mechanism for RA treatment remain unclear. In this study, we used a combination of gas chromatography-mass spectrom… Show more
“…EGFR, TNF, INS and PIK3CA play important roles in RA occurrence and development, and their abnormal expressions may aggravate RA. [47][48][49][50] Furthermore, GO and KEGG enrichment analyses showed that these core targets are mainly involved in the PI3K-Akt signalling pathway, IL-17 signalling pathway and cancer pathways. The PISK-Akt signalling pathway can inhibit RASF autophagy and promote the continuous proliferation of synovial cells by acting on mTOR, which can exacerbate RA.…”
Millettia speciosa (M. speciosa) Champ (MSC) is a healthy food type with medicinal and edible homology, which is now considered a clinically significant anti-rheumatoid arthritis medicine. However, there is currently...
“…EGFR, TNF, INS and PIK3CA play important roles in RA occurrence and development, and their abnormal expressions may aggravate RA. [47][48][49][50] Furthermore, GO and KEGG enrichment analyses showed that these core targets are mainly involved in the PI3K-Akt signalling pathway, IL-17 signalling pathway and cancer pathways. The PISK-Akt signalling pathway can inhibit RASF autophagy and promote the continuous proliferation of synovial cells by acting on mTOR, which can exacerbate RA.…”
Millettia speciosa (M. speciosa) Champ (MSC) is a healthy food type with medicinal and edible homology, which is now considered a clinically significant anti-rheumatoid arthritis medicine. However, there is currently...
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