NETosis as a Pathogenic Factor for Heart Failure

Ling, Shuang; Xu, Jin-Wen

doi:10.1155/2021/6687096

Cited by 37 publications

(32 citation statements)

References 278 publications

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“…As previously discussed, circulating MPO levels are an independent risk factor associated with cardiovascular disease. NETs, as a more complex structure (that also includes MPO), are involved in cardiac inflammation, myocardial infarction, and atrial fibrillation, though it is unclear if they are the cause or the consequence of these morbidities [ 172 , 173 ].…”

Section: Neutrophil Extracellular Traps (Nets) At the Crossroads Of Defence And Diseasementioning

confidence: 99%

“…Furthermore, higher NET levels were detected in the plasma of Brazilian Alzheimer's disease patients compared to healthy controls, which may be associated to complement system activity [ 174 ]. Importantly, damage-associated molecular patterns (such as mitochondrial DNA, fibronectin extra domain A, and galectin-3) released during tissue damage may activate NETs through interaction with neutrophil surface proteins [ 172 ]. In addition, NETs can be triggered by cytokines [ 175 ], platelets [ 176 ], nitric oxide and peroxynitrite [ 177 ], and numerous microcrystals (of urate, calcium, cholesterol, and silica) [ 178 ], and numerous microbes (bacteria, viruses, yeast, parasites) [ 179 ].…”

Section: Neutrophil Extracellular Traps (Nets) At the Crossroads Of Defence And Diseasementioning

confidence: 99%

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The many roles of myeloperoxidase: From inflammation and immunity to biomarkers, drug metabolism and drug discovery

Siraki

2021

Redox Biology

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This review provides a practical guide to myeloperoxidase (MPO) and presents to the reader the diversity of its presence in biology. The review provides a historical background, from peroxidase activity to the discovery of MPO, to its role in disease and drug development. MPO is discussed in terms of its necessity, as specific individuals lack MPO expression. An underlying theme presented throughout brings up the question of the benefit and burden of MPO activity. Enzyme structure is discussed, including accurate masses and glycosylation sites. The catalytic cycle of MPO and its corresponding pathways are presented, with a discussion of the importance of the redox couples of the different states of MPO. Cell lines expressing MPO are discussed and practically summarized for the reader, and locations of MPO (primary and secondary) are provided. Useful methods of MPO detection are discussed, and how these can be used for studying disease processes are implied through the presentation of MPO as a biomarker. The presence of MPO in neutrophil extracellular traps is presented, and the activators of the former are provided. Lastly, the transition from drug metabolism to a target for drug development is where the review concludes.

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Section: Neutrophil Extracellular Traps (Nets) At the Crossroads Of Defence And Diseasementioning

confidence: 99%

Section: Neutrophil Extracellular Traps (Nets) At the Crossroads Of Defence And Diseasementioning

confidence: 99%

The many roles of myeloperoxidase: From inflammation and immunity to biomarkers, drug metabolism and drug discovery

Siraki

2021

Redox Biology

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“…NETs promote coronary microvascular thrombosis and affect heart function ( 36 ). The content of NETs in cardiogenic thrombosis is higher than that in thrombosis with other causes ( 37 ).…”

Section: The Role Of Nets In Atherosclerosis and Arterial Thrombosismentioning

confidence: 99%

The Emerging Role of Neutrophil Extracellular Traps in Arterial, Venous and Cancer-Associated Thrombosis

Zhou

Tao

Shen

et al. 2021

Front. Cardiovasc. Med.

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Neutrophils play a vital role in the formation of arterial, venous and cancer-related thrombosis. Recent studies have shown that in a process known as NETosis, neutrophils release proteins and enzymes complexed to DNA fibers, collectively called neutrophil extracellular traps (NETs). Although NETs were originally described as a way for the host to capture and kill bacteria, current knowledge indicates that NETs also play an important role in thrombosis. According to recent studies, the destruction of vascular microenvironmental homeostasis and excessive NET formation lead to pathological thrombosis. In vitro experiments have found that NETs provide skeletal support for platelets, red blood cells and procoagulant molecules to promote thrombosis. The protein components contained in NETs activate the endogenous coagulation pathway to promote thrombosis. Therefore, NETs play an important role in the formation of arterial thrombosis, venous thrombosis and cancer-related thrombosis. This review will systematically summarize and explain the study of NETs in thrombosis in animal models and in vivo experiments to provide new targets for thrombosis prevention and treatment.

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“…It has been documented that several NET-related heart and systemic diseases including, atrial fibrillation, myocardial infarction (MI), hypertrophic cardiomyopathy, myocarditis, diabetes, chronic kidney disease, chronic obstructive pulmonary disease, and autoimmune diseases, could be cause heart failure [90]. Based on available knowledge, NETs may be accompanied by aseptic inflammation and microthrombosis, inducing myocardial ischemia-reperfusion (I/R) and MI [91].…”

Section: Heart Failure and Cardiomyopathymentioning

confidence: 99%

Inhibition of NETosis for treatment purposes: friend or foe?

Chamardani

Amiritavassoli

2022

Mol Cell Biochem

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Active neutrophils participate in innate and adaptive immune responses through various mechanisms, one of the most important of which is the formation and release of neutrophil extracellular traps (NETs). The NETs are composed of network-like structures made of histone proteins, DNA and other released antibacterial proteins by activated neutrophils, and evidence suggests that in addition to the innate defense against infections, NETosis plays an important role in the pathogenesis of several other non-infectious pathological states, such as autoimmune diseases and even cancer. Therefore, targeting NET has become one of the important therapeutic approaches and has been considered by researchers. NET inhibitors or other molecules involved in the NET formation, such as the protein arginine deiminase 4 (PAD4) enzyme, an arginine-to-citrulline converter, participate in chromatin condensation and NET formation, is the basis of this therapeutic approach. The important point is whether complete inhibition of NETosis can be helpful because by inhibiting this mechanism, the activity of neutrophils is suppressed. In this review, the biology of NETosis and its role in the pathogenesis of some important diseases have been summarized, and the consequences of treatment based on inhibition of NET formation have been discussed.

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NETosis as a Pathogenic Factor for Heart Failure

Cited by 37 publications

References 278 publications

The many roles of myeloperoxidase: From inflammation and immunity to biomarkers, drug metabolism and drug discovery

The many roles of myeloperoxidase: From inflammation and immunity to biomarkers, drug metabolism and drug discovery

The Emerging Role of Neutrophil Extracellular Traps in Arterial, Venous and Cancer-Associated Thrombosis

Inhibition of NETosis for treatment purposes: friend or foe?

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