NET1 is a critical regulator of spindle assembly and actin dynamics in mouse oocytes
Shiwei Wang,
Xuan Wu,
Mengmeng Zhang
et al.
Abstract:Background
Neuroepithelial transforming gene 1 (NET1) is a RhoA subfamily guanine nucleotide exchange factor that governs a wide array of biological processes. However, its roles in meiotic oocyte remain unclear. We herein demonstrated that the NET1-HACE1-RAC1 pathway mediates meiotic defects in the progression of oocyte maturation.
Methods
NET1 was reduced using a specific small interfering RNA in mouse oocytes. Spindle assembly, chromosomal align… Show more
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