Net Transport in the Intervertebral Disc is Dependent on Mechanical Loading Rate

Linley, Sarah E.; Peterson, Josh; Mastropolo, Rosemarie; Roberts, Timothy T.; Frank, Sarah; Glennon, Joseph C.; Lawrence, James P.; Ledet, Eric H.

doi:10.1016/j.spinee.2013.07.159

The Spine Journal

2013

DOI: 10.1016/j.spinee.2013.07.159

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Net Transport in the Intervertebral Disc is Dependent on Mechanical Loading Rate

Sarah E. Linley

Josh Peterson

Rosemarie Mastropolo

et al.

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“…Mechanical studies demonstrate that dynamic loading on the disc at the frequency and loading magnitudes typical of bipedal walking or running increase nutrient flow. 114 In contrast, static, high rate, or high magnitude loading are all detrimental to disc nutrition. 184,199 Dynamic mechanical loading on a hydrated material such as the disc results in increased material stiffness when compared with static loading.…”

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confidence: 99%

Etiology of lumbar lordosis and its pathophysiology: a review of the evolution of lumbar lordosis, and the mechanics and biology of lumbar degeneration

Sparrey

Bailey

Safaee

et al. 2014

FOC

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The goal of this review is to discuss the mechanisms of postural degeneration, particularly the loss of lumbar lordosis commonly observed in the elderly in the context of evolution, mechanical, and biological studies of the human spine and to synthesize recent research findings to clinical management of postural malalignment. Lumbar lordosis is unique to the human spine and is necessary to facilitate our upright posture. However, decreased lumbar lordosis and increased thoracic kyphosis are hallmarks of an aging human spinal column. The unique upright posture and lordotic lumbar curvature of the human spine suggest that an understanding of the evolution of the human spinal column, and the unique anatomical features that support lumbar lordosis may provide insight into spine health and degeneration. Considering evolution of the skeleton in isolation from other scientific studies provides a limited picture for clinicians. The evolution and development of human lumbar lordosis highlight the interdependence of pelvic structure and lumbar lordosis. Studies of fossils of human lineage demonstrate a convergence on the degree of lumbar lordosis and the number of lumbar vertebrae in modern Homo sapiens. Evolution and spine mechanics research show that lumbar lordosis is dictated by pelvic incidence, spinal musculature, vertebral wedging, and disc health. The evolution, mechanics, and biology research all point to the importance of spinal posture and flexibility in supporting optimal health. However, surgical management of postural deformity has focused on restoring posture at the expense of flexibility. It is possible that the need for complex and costly spinal fixation can be eliminated by developing tools for early identification of patients at risk for postural deformities through patient history (genetics, mechanics, and environmental exposure) and tracking postural changes over time.

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mentioning

confidence: 99%

Etiology of lumbar lordosis and its pathophysiology: a review of the evolution of lumbar lordosis, and the mechanics and biology of lumbar degeneration

Sparrey

Bailey

Safaee

et al. 2014

FOC

View full text Add to dashboard Cite

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Net Transport in the Intervertebral Disc is Dependent on Mechanical Loading Rate

Cited by 1 publication

References 0 publications

Etiology of lumbar lordosis and its pathophysiology: a review of the evolution of lumbar lordosis, and the mechanics and biology of lumbar degeneration

Etiology of lumbar lordosis and its pathophysiology: a review of the evolution of lumbar lordosis, and the mechanics and biology of lumbar degeneration

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