Nested sensitive periods: how plasticity across the microbiota-gut-brain axis interacts to affect the development of learning and memory

Callaghan, Brid

doi:10.1016/j.cobeha.2020.07.011

Cited by 15 publications

(17 citation statements)

References 61 publications

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“…A number of studies have explored the relationship between the gut microbiota and the development of learning and memory systems in childhood [ 77 ]. This has led to a growing appreciation that sensitive periods of development occur across the microbiota–gut–brain axis.…”

Section: The Two-way Street Between Gut and Brainmentioning

confidence: 99%

“…From animal studies, there is increasing evidence that changes in the gut microbiota alter performance in relation to visual-spatial learning and memory tasks [ 78 ]. Although there are still few human data, one study has associated microbial diversity with cognitive functioning in infancy [ 77 ].…”

Section: The Two-way Street Between Gut and Brainmentioning

confidence: 99%

“…A new approach to cognitive development research is required, including the microbiota–gut–brain axis as a peripheral force among the complex biological systems that act on behaviour. By improving understanding, this may lay the foundation for innovative therapies for learning and memory disorders [ 77 ].…”

Section: The Two-way Street Between Gut and Brainmentioning

confidence: 99%

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The microbiota–gut–brain axis: pathways to better brain health. Perspectives on what we know, what we need to investigate and how to put knowledge into practice

Chakrabarti

Geurts

Hoyles

et al. 2022

Cell. Mol. Life Sci.

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The gut and brain link via various metabolic and signalling pathways, each with the potential to influence mental, brain and cognitive health. Over the past decade, the involvement of the gut microbiota in gut–brain communication has become the focus of increased scientific interest, establishing the microbiota–gut–brain axis as a field of research. There is a growing number of association studies exploring the gut microbiota’s possible role in memory, learning, anxiety, stress, neurodevelopmental and neurodegenerative disorders. Consequently, attention is now turning to how the microbiota can become the target of nutritional and therapeutic strategies for improved brain health and well-being. However, while such strategies that target the gut microbiota to influence brain health and function are currently under development with varying levels of success, still very little is yet known about the triggers and mechanisms underlying the gut microbiota’s apparent influence on cognitive or brain function and most evidence comes from pre-clinical studies rather than well controlled clinical trials/investigations. Filling the knowledge gaps requires establishing a standardised methodology for human studies, including strong guidance for specific focus areas of the microbiota–gut–brain axis, the need for more extensive biological sample analyses, and identification of relevant biomarkers. Other urgent requirements are new advanced models for in vitro and in vivo studies of relevant mechanisms, and a greater focus on omics technologies with supporting bioinformatics resources (training, tools) to efficiently translate study findings, as well as the identification of relevant targets in study populations. The key to building a validated evidence base rely on increasing knowledge sharing and multi-disciplinary collaborations, along with continued public–private funding support. This will allow microbiota–gut–brain axis research to move to its next phase so we can identify realistic opportunities to modulate the microbiota for better brain health.

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Section: The Two-way Street Between Gut and Brainmentioning

confidence: 99%

Section: The Two-way Street Between Gut and Brainmentioning

confidence: 99%

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The microbiota–gut–brain axis: pathways to better brain health. Perspectives on what we know, what we need to investigate and how to put knowledge into practice

Chakrabarti

Geurts

Hoyles

et al. 2022

Cell. Mol. Life Sci.

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“…There are multiple ways in which the bacterial products of the BeeCom_001 may promote olfactory learning and memory performance. First, they might participate in brain maturation and cognitive development, as observed in humans and mice 26,27 . Honey bees acquire their gut microbiota during perinatal life, concomitantly to structural and functional brain maturation 28,29 .…”

Section: Discussionmentioning

confidence: 99%

A defined community of core gut microbiota members promotes cognitive performance in honey bees

Cabirol

Schafer

Neuschwander

et al. 2023

Preprint

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The composition of the gut microbiota has recently been identified as a cause of cognitive variability in humans and animals. Germ-free individuals and individuals exposed to an antibiotic treatment show severe alteration of their learning and memory performance measured in various cognitive tasks. While different species of bacteria are known to interact in the gut, their cumulative or synergistic effects on cognitive performance remain elusive. Here we established a defined bacterial community - composed of core members of the corbiculate bee microbiota - which enhances honey bee cognitive capacities. Honey bees colonized with this reconstituted community discriminated better two odours based on the presence or absence of a sucrose reward compared to germ-free individuals. They also memorized better these odour-food associations in the short-term. These cognitive improvements seem to constitute an emergent property of the community, because they could not be recapitulated by any of the community member when mono-associated in gnotobiotic bees and they were not explained by the total biomass in the gut. The identification of this community and its effect on bees open new avenues of research in neuroscience, microbiology, and ecology. Future research should help understanding how interactions between bacterial species in the community promote the host associative learning and memory performance.

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“…The gut microbiome has become increasingly relevant to adolescence, a key period of neurobiological and social-affective development. Cognitive impairments following alterations in the microbiome have led to the theory of a gut-microbiome-cognition connection (Callaghan, 2020). The use of food ingredients and their preparation are very important for the development and well-being of brain cells.…”

Section: Food and Nutritionmentioning

confidence: 99%

A Flourishing Brain in the 21st Century: A Scoping Review of the Impact of Developing Good Habits for Mind, Brain, Well‐Being, and Learning

Ekman

Fletcher

Giota

et al. 2021

Mind Brain and Education

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Emerging scientific knowledge such as the role of epigenetics and neuroplasticity-the brain's capability to constantly rewire with every action, experience, and thought-is fundamentally changing our understanding of the potential impact we can have on our brain. Our brain is formed by our habits in interaction with our body, the environment, influenced by our lifestyle, successes, failures, and traumas. Neuroplasticity proves that every student's brain is a work in progress, and it is never too late to take better care of one's cognitive fitness. This review presents a repertoire of good habits (GHs). Combined, we suggest that these GHs provide conditions for optimal brain health, by acting as a "Mental Vaccine" which enhances the brain's resilience to brain health-degrading challenges. We argue

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Nested sensitive periods: how plasticity across the microbiota-gut-brain axis interacts to affect the development of learning and memory

Cited by 15 publications

References 61 publications

The microbiota–gut–brain axis: pathways to better brain health. Perspectives on what we know, what we need to investigate and how to put knowledge into practice

The microbiota–gut–brain axis: pathways to better brain health. Perspectives on what we know, what we need to investigate and how to put knowledge into practice

A defined community of core gut microbiota members promotes cognitive performance in honey bees

A Flourishing Brain in the 21st Century: A Scoping Review of the Impact of Developing Good Habits for Mind, Brain, Well‐Being, and Learning

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