Nested melanoma

Kossard, Steven

doi:10.1038/modpathol.2012.219

Cited by 3 publications

(4 citation statements)

References 5 publications

(2 reference statements)

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“…22,24 Important additional clues may include focal pagetoid spread of melanocytes and thinning of epidermal rim surrounding the nests. 21 The malignant nature of this variant of melanoma has been confirmed by means of genetic analyses, as indicated by presence of multiple chromosomal aberrations. 24…”

Section: Nested Melanoma Of the Elderlymentioning

confidence: 95%

“…2). 20,21 Given the bland appearance of such lesions and similarity to benign junctional nevi in their growing phase (observed mainly in children), nested melanoma of the elderly may be regarded as part of the heterogeneous spectrum of nevoid melanomas. 22 Predictably, in light of histological similarities with nested junctional nevi in children, the corresponding clinicodermatoscopical features are characterized by an irregular globular pattern.…”

Section: Nested Melanoma Of the Elderlymentioning

confidence: 99%

“…23 Histopathologically, nested melanoma of the elderly is characterized by a superficial (mainly junctional) proliferation of cells mostly arranged in large, cannonball-like irregular nests strikingly predominating over solitary melanocytes. 20,21,24 A key finding favoring a diagnosis of melanoma is presence of actinic elastosis in the dermis. 21,22 Indeed, any melanocytic neoplasm with such histological features in an elderly patient should be regarded as strongly suspicious for melanoma.…”

Section: Nested Melanoma Of the Elderlymentioning

confidence: 99%

“…20,21,24 A key finding favoring a diagnosis of melanoma is presence of actinic elastosis in the dermis. 21,22 Indeed, any melanocytic neoplasm with such histological features in an elderly patient should be regarded as strongly suspicious for melanoma. 22,24 Important additional clues may include focal pagetoid spread of melanocytes and thinning of epidermal rim surrounding the nests.…”

Section: Nested Melanoma Of the Elderlymentioning

confidence: 99%

See 3 more Smart Citations

Uncommon Histopathological Variants of Malignant Melanoma. Part 2

Saggini

Cota

Lora

et al. 2019

The American Journal of Dermatopathology

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Despite new horizons opened by recent advances in molecular pathology, histological evaluation still remains the diagnostic gold standard regarding cutaneous melanocytic neoplasms. Several histological variants of melanoma have been described, and their knowledge is crucial for accurate diagnosis and classification of cases with unusual clinico-pathological features. Uncommon histological variants of melanoma have been described based on a broad constellation of features, including architectural pattern, stromal alterations, cytological attributes, and other morphological properties. This review is aimed at providing an extensive discussion of unusual but distinctive histopathological variants of melanoma.

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