The coronavirus disease 2019 (COVID-19) pandemic has illuminated the gap in training students in the health professions to function in environments of both certainty and uncertainty. Medical students are typically presented with facts, associations, and algorithms, and are later assessed through methods that either has a single correct answer or a series of acceptable answers with a single meaning (eg, multiple-choice examinations and objective structured clinical examinations). 1 The transition from the classroom to the clinical learning environment poses medical students with significant struggles. These may include struggles with diagnosis, management, communication, patient care, and care coordination. To date, formal training and assessment to enhance comfort with and management of uncertainty in clinical practice are lacking in many training programs. 1 A curriculum in Health Systems Science (HSS) can specifically acknowledge and address the uncertainty intrinsic to modern medical care and, in doing so, better prepare students for the transition to the clinical environment, the intrinsic complexity of the healthcare system, and the uncertainty of professional clinical practice.