Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system

Yosten, Gina L. C.; Samson, Willis K.

doi:10.1152/ajpregu.90867.2008

Cited by 171 publications

(208 citation statements)

References 27 publications

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“…Nucleobindin 2 is the precursor of a secreted calcium-binding protein, nesfatin-1, that influences the excitability of neurons in a part of the brain associated with stress and physiological changes (52). It stimulates autonomic nervous system activity, increases blood pressure (53), and has been associated with a range of brain functions, including the regulation of feeding. Nucleobindin induces fear and anxiety in rats (54).…”

Section: Resultsmentioning

confidence: 99%

Proteomics and Deep Sequencing Comparison of Seasonally Active Venom Glands in the Platypus Reveals Novel Venom Peptides and Distinct Expression Profiles

Wong

Morgenstern

Mofiz

et al. 2012

Molecular & Cellular Proteomics

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Section: Resultsmentioning

confidence: 99%

Proteomics and Deep Sequencing Comparison of Seasonally Active Venom Glands in the Platypus Reveals Novel Venom Peptides and Distinct Expression Profiles

Wong

Morgenstern

Mofiz

et al. 2012

Molecular & Cellular Proteomics

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“…This became more definite using higher dose of nesfatin-1. Yosten et al 4 did not find any change in heart rate after nesfatin-1 treatment during the light phase, but they measured it only for 1 h after injection.…”

Section: Discussionmentioning

confidence: 95%

“…There is a general consensus in the literature that nesfatin-1 itself is able to increase sympathetic activity, therefore such interaction is not surprising. 4,23 It is interesting, however, that there was no effect of nesfatin-1 on the heart rate applied at night, meanwhile a limited and belated (starting more than 1 h after injection) heart rate elevation was observed, when it was given during the light phase. This became more definite using higher dose of nesfatin-1.…”

Section: Discussionmentioning

confidence: 99%

“…36,37 Moreover, many effects of nesfatin-1 are mediated through melanocortin-3/4 receptors, and the melanocortin-3/4 receptor antagonist SHU9119 significantly decreases BAT temperature. 4,23,38 In addition, prepro-TRH, precursor of TRH, a key factor regulating basal metabolic rate and thermogenesis, co-localised in the cold responsive nesfatin-1/NUCB2 cells in the PVN and in the brainstem raphe nuclei. 12 Although Johnson et al 20 suggested colchicine treatment for TRH immunostaining, the prepro-TRH antibody we used worked without it.…”

Section: Discussionmentioning

confidence: 99%

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Nesfatin-1 exerts long-term effect on food intake and body temperature

Könczöl

Pintér²,

Ferenczi

et al. 2012

Int J Obes

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OBJECTIVE:To determine whether the anorexigenic peptide, nesfatin-1 affects energy expenditure, and to follow the time course of its effects. DESIGN: Food intake duration, core body temperature, locomotor activity and heart rate of rats were measured by telemetry for 48 h after a single intracerebroventricular injection of 25 or 100 pmol nesfatin-1 applied in the dark or the light phase of the day. Body weight, food and water intake changes were measured daily. Furthermore, cold-responsive nesfatin-1/NUCB2 neurons were mapped in the brain. RESULTS: Nesfatin-1 reduced duration of nocturnal food intake for 2 days independently of circadian time injected, and raised body temperature immediately, or with little delay depending on the dose and circadian time applied. The body temperature remained higher during the next light phases of the 48 h observation period, and the circadian curve of temperature flattened. After light phase application, the heart rate was elevated transiently. Locomotion did not change. Daily food and water intake, as well as body weight measurements point to a potential decrease in all parameters on the first day and some degree of compensation on the second day. Cold-activated (Fos positive) nesfatin-1/NUCB2 neurones have been revealed in several brain nuclei involved in cold adaptation. Nesfatin-1 co-localised with prepro-thyrotropin-releasing hormone in cold responsive neurones of the hypothalamic paraventricular nucleus, and in neurones of the nucleus raphe pallidus and obscurus that are premotor neurones regulating brown adipose tissue thermogenesis and skin blood flow. CONCLUSION: Nesfatin-1 has a remarkably prolonged effect on food intake and body temperature. Time course of nesfatin-1's effects may be varied depending on the time applied. Many of the nesfatin-1/NUCB2 neurones are cold sensitive, and are positioned in key centres of thermoregulation. Nesfatin-1 regulates energy expenditure a far more potent way than it was recognised before making it a preferable candidate anti-obesity drug.

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“…Recently studies have been shown an increasing blood pressure with administration of nesfatin-1. It has also been shown to play an important roles in the control of cardiovascular function (23,24). However, the effect mechanism of nesfatin-1 on the blood pressure is not clear.…”

Section: Introductionmentioning

confidence: 99%

Supplementation of apelin increase plasma levels of nesfatin-1 in normal and DOCA-salt hypertensive rats

Akçılar¹,

Ayada²,

Turgut³

et al. 2015

BLL

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Aims:We aimed to observe the effects of apelin supplementation on the plasma levels of nesfatin-1 in DOCA-salt hypertensive and normal rats. Methods: For this purpose, 28 young Wistar albino male rats were divided into four groups; Control (C), Control + Apelin (C+A), Hypertension (HT) and Hypertension + Apelin (HT+A). Hypertension was induced by injection of DOCA-salt (25 mg/kg, s.c.) twice weekly, 4 weeks, whereas intraperitoneal apelin was administered (200 μg.kg -1 ) for 17 days. Plasma nesfatin-1 and apelin levels were measured with ELISA. Systolic blood pressure was monitored using a tail cuff system. The relationships between plasma nesfatin levels and blood pressure were assessed. Results: Plasma nesfatin-1 levels was found lower in control animals compared to C+A, HT and HT+A groups (p = 0.002, p = 0.026 and p = 0.011, respectively). Systolic blood pressures were similar in the C and C+A groups, but systolic blood pressures of the HT and HT+A groups was found signifi cantly higher than the C and C+A groups. Conclusions: In conclusion, apelin administration induced an increment of nesfatin-1 in normal rats and plasma levels of nesfatin-1 increase in DOCA-salt hypertension rats. But apelin addition in hypertension did not cause an extra increase in nesfatin-1 levels. This is the fi rst report to investigate the effect of apelin administration on plasma nesfatin levels of normal and hypertensive rats (Fig. 2, Ref. 44). Text in PDF www.elis.sk.

show abstract

Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system

Cited by 171 publications

References 27 publications

Proteomics and Deep Sequencing Comparison of Seasonally Active Venom Glands in the Platypus Reveals Novel Venom Peptides and Distinct Expression Profiles

Proteomics and Deep Sequencing Comparison of Seasonally Active Venom Glands in the Platypus Reveals Novel Venom Peptides and Distinct Expression Profiles

Nesfatin-1 exerts long-term effect on food intake and body temperature

Supplementation of apelin increase plasma levels of nesfatin-1 in normal and DOCA-salt hypertensive rats

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