Nervus Opticus

Naumann, G. O. H.; Apple, David J.; Wenkel, Hartmut

doi:10.1007/978-3-642-60402-7_5

Cited by 2 publications

(4 citation statements)

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“…Since increased diameters of retinal veins have been well described and are a hallmark of high altitude retinopathy, it seems plausible that this mechanism may be responsible for the ONH changes observed at high altitude. Cytotoxic intracellular edema as described for the brain by MRI studies at normobaric hypoxia [43] may also contribute to ODE as a result of reduced axonal transport [17] , [47] .…”

Section: Discussionmentioning

confidence: 99%

Quantification of Optic Disc Edema during Exposure to High Altitude Shows No Correlation to Acute Mountain Sickness

Willmann¹,

Fischer²,

Schatz³

et al. 2011

PLoS ONE

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BackgroundThe study aimed to quantify changes of the optic nerve head (ONH) during exposure to high altitude and to assess a correlation with acute mountain sickness (AMS). This work is related to the Tuebingen High Altitude Ophthalmology (THAO) study.Methodology/Principal FindingsA confocal scanning laser ophthalmoscope (cSLO, Heidelberg Retina Tomograph, HRT3®) was used to quantify changes at the ONH in 18 healthy participants before, during and after rapid ascent to high altitude (4559 m). Slitlamp biomicroscopy was used for clinical optic disc evaluation; AMS was assessed with Lake Louise (LL) and AMS-cerebral (AMS-c) scores; oxygen saturation (SpO2) and heart rate (HR) were monitored. These parameters were used to correlate with changes at the ONH. After the first night spent at high altitude, incidence of AMS was 55% and presence of clinical optic disc edema (ODE) 79%. Key stereometric parameters of the HRT3® used to describe ODE (mean retinal nerve fiber layer [RNFL] thickness, RNFL cross sectional area, optic disc rim volume and maximum contour elevation) changed significantly at high altitude compared to baseline (p<0.05) and were consistent with clinically described ODE. All changes were reversible in all participants after descent. There was no significant correlation between parameters of ODE and AMS, SpO2 or HR.Conclusions/SignificanceExposure to high altitude leads to reversible ODE in the majority of healthy subjects. However, these changes did not correlate with AMS or basic physiologic parameters such as SpO2 and HR. For the first time, a quantitative approach has been used to assess these changes during acute, non-acclimatized high altitude exposure. In conclusion, ODE presents a reaction of the body to high altitude exposure unrelated to AMS.

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Section: Discussionmentioning

confidence: 99%

Quantification of Optic Disc Edema during Exposure to High Altitude Shows No Correlation to Acute Mountain Sickness

Willmann¹,

Fischer²,

Schatz³

et al. 2011

PLoS ONE

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“…Die ursächliche granulomatöse Gefäûentzündung verschwindet auch nicht sofort nach Einleitung einer Kortikosteroidmedikation. Das Ergebnis einer Arterienbiopsie bis zu einer Woche nach Therapieeinleitung wird durch die Kortikosteroide nur wenig beeinträchtigt [15,18]. Selbst Wochen und Monate nach Therapiebeginn wurden in Arterienbiopsaten noch charakteristische histologische Veränderungen gefunden [10,18].…”

Section: Patienten Und Methodenunclassified

“…Key words: Temporal arteritis ± bilateral amourosis ± ischemic optic neuropathy Die Riesenzellarteriitis (RZA) ist eine systemische Vaskulitis, die bei etwa 50 ± 60 % der Patienten zu einer okulären Beteiligung führt [7,11,15,16,21]. Neben einer anterioren ischämi- schen Optikoneuropathie (AION), einer sekundären komplexen Optikusatrophie und einem Zentralarterienverschluss (ZAV) ist eine Vielzahl verschiedener okulärer Manifestationen bekannt [7,11,15,16,19,21].…”

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“…Neben einer anterioren ischämi- schen Optikoneuropathie (AION), einer sekundären komplexen Optikusatrophie und einem Zentralarterienverschluss (ZAV) ist eine Vielzahl verschiedener okulärer Manifestationen bekannt [7,11,15,16,19,21]. Die okuläre Beteiligung verläuft bei etwa der Hälfte der Patienten unilateral, kann aber simultan oder nach einem Intervall auch das kontralaterale Auge betreffen [11].…”

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Bilaterale Amaurose bei 11 Patienten mit histologisch gesicherter Riesenzellarteriitis1

Wenkel¹

2001

Klin Monatsbl Augenheilkd

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Nervus Opticus

Cited by 2 publications

References 331 publications

Quantification of Optic Disc Edema during Exposure to High Altitude Shows No Correlation to Acute Mountain Sickness

Quantification of Optic Disc Edema during Exposure to High Altitude Shows No Correlation to Acute Mountain Sickness

Bilaterale Amaurose bei 11 Patienten mit histologisch gesicherter Riesenzellarteriitis1

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