Nervous system manifestations in Sjögren's syndrome

Abstract

Central and peripheral manifestations of the nervous system were evaluated in 48 Sjögren's syndrome patients. Fifty‐six percent of the patients had neurological disturbances. The most common manifestations were entrapment neuropathies (19%) and polyneuropathy (15%). Electrophysiological tests gave further evidence of subclinical nervous system involvement in Sjögren's syndrome: electroencephalography (EEG) was abnormal in 48%, and visual evoked potentials (VEP) in 12% of patients tested. To find possible neuropsychiatric abnormalities, the Minnesota Multiphasic Personality Inventory was applied, and 33/43 patients were found to have psychiatric symptoms. The most frequent were depressive symptoms. In 44% of the patients there was additional evidence of extraglandular involvement or autoimmune disorders. No correlation could be found between the groups of patients with or without neurological disturbances in relation to simultaneous occurrence of associated disorders. It is suggested that nervous system involvement in Sjögren's syndrome reflects the pathogenetic consequences of Sjögren's syndrome alone, and not those of associated autoimmune diseases or extraglandular disorders.

Gougerot Sjögren Syndrome Mimicking Multiple Sclerosis

“…RBON frequency is variable from 12 to 61% of patients. The RBON can sometimes be bilateral [9,11]. In our case, the patient presented a bilateral RBON and an involvement of the common oculomotor nerve (III).…”

A clinically isolated syndrome: A challenging entity

“…It is the most common presentation in MS (90 %) [42][43][44] but can also be seen initially in SLE and pSS [47][48][49][50][51]. The conversion rate from isolated optic neuritis and TM to clinically definite MS (CDMS) varies greatly.…”

Rheumatoid Arthritis Patients with Sjogrens Syndrome are More Prone to Depression than Patients with Rheumatoid Arthritis or Sjogrens Syndrome Alone

“…The disease primarily involves infiltration of the salivary and lachrymal glands by lymphocytes and plasma cells [4], resulting in oral and ocular dryness (sicca symptoms), though secretary glands in any mucus membrane may be affected. The most frequent symptom triad is muscular and joint pain, sicca symptoms and fatigue [5,6], but primary SS patients also frequently experience a wide spectrum of extraglandular symptoms affecting various organs and, when the central nervous system is affected [7,8], may exhibit psychiatric symptoms [9][10][11].…”