Nervous System Involvement in Paediatric Coeliac Patients

Papadatou, B.; Capua, M. Di; Gambarara, M.; Castellucci, G; Lucidi, V.; Ferretti, Francesca; Colombo, A. M.; Bella, Sergio; Castro, M.

doi:10.1007/978-94-015-7943-8_45

Cited by 3 publications

(3 citation statements)

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“…Antibody titres did not uniformly correlate with gluten ingestion, showing both increase and reduction after gluten‐free diet, suggesting that they might be induced by mechanisms different from gluten exposure. Only a few cases of children with CD and neuropathy have been described 5, 11, 12 . The response to diet is controversial, with onset of neuropathy following gluten ingestion, 12 but also occurring during gluten‐free diet, 5, 11 questioning a direct neurotoxic effect of gluten.…”

Section: Discussionmentioning

confidence: 99%

“…Only a few cases of children with CD and neuropathy have been described 5, 11, 12 . The response to diet is controversial, with onset of neuropathy following gluten ingestion, 12 but also occurring during gluten‐free diet, 5, 11 questioning a direct neurotoxic effect of gluten. One of the reported cases, 11 still currently followed by one of the authors (GG), developed a progressive motor axonal neuropathy at 2.5 years of age, after being in gluten‐free diet for 6 months.…”

Section: Discussionmentioning

confidence: 99%

“…In adults, CD is often diagnosed for symptoms other than gastrointestinal disturbances, with neuropathy and ataxia being the most common neurological presentation 2–4 . Although less frequent, neurological complications occur also in children, and include encephalopathy, myelopathy, myopathy, psychiatric disturbances and peripheral neuropathy 5 . Moreover, occipital epilepsy with calcifications may underscore CD 6, 7 .…”

Section: Introductionmentioning

confidence: 99%

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Anti‐ganglioside antibodies in children with coeliac disease: correlation with gluten‐free diet and neurological complications

Briani

Ruggero²,

Zara³

et al. 2004

Aliment Pharmacol Ther

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Summary Background : Emerging evidence points to humoural mechanisms in neurological complications of coeliac disease. Immunoglobulin G anti‐ganglioside antibodies have been reported in coeliac disease patients with neuropathy, suggesting an immune response to peripheral nerve antigens. No data are so far available on anti‐ganglioside antibodies in coeliac disease children or on antibody modifications after gluten‐free diet. Aim : To evaluate the presence of antibodies to ganglioside antigens in children with coeliac disease, their modification after gluten‐free diet, and possible correlations with neurological manifestations. Methods : Sera from 42 coeliac disease children, before and after gluten‐free diet, were tested by enzyme‐linked immunosorbent assay for the presence of antibodies (immunoglobulin M, immunoglobulin A, immunoglobulin G) to gangliosides. Thirty‐five sera of age‐matched children with dyspepsia were used as control. Results : High anti‐ganglioside antibodies titres were present in two patients. In one patient, antibody titre reversed after gluten‐free diet, whereas in the other one the titre increased after diet. Neither one complained of neurological symptoms. Conclusions : Anti‐ganglioside antibodies do not seem to correlate with gluten ingestion or with neurological manifestations in children with coeliac disease. Mechanisms different from gluten exposure may be implicated in the antibody production. An ongoing prospective study will help clarify the role, if any, of these antibodies in coeliac disease.

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Section: Discussionmentioning

confidence: 99%