Nerve Sheaths in the Leptomeningeal Connective Tissue

Krahn, V

doi:10.1159/000145729

Cited by 4 publications

(3 citation statements)

References 13 publications

(21 reference statements)

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“…Even if the majority of afferent fibers is localized in the advential leptomeninx, there are additionally affer- ent nerve fiber bundles that are merely in transit to the trabecular and pial leptomeninx. Some authors already suggested a sensory innervation of the leptomeninx itself, designated as "nervi proprii" (Clark, 1931;Huber, 1897;Krahn 1983;Stöhr, 1940), which has been unequivocally confirmed by Fricke et al (1997).…”

Section: Innervation Of the Leptomeninxmentioning

confidence: 97%

Nerve fibers innervating the cranial and spinal meninges: Morphology of nerve fiber terminals and their structural integration

Fricke

Andres

Düring

2001

Microscopy Res & Technique

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Pachymeninx and leptomeninx of cranial cavity and spine are considerably different in their collagenous fiber texture, cellular composition, vascularization, and innervation. The majority of meningeal nerve fibers terminate as free nerve endings whereas encapsulated and lamellated nerve terminals additionally occur in higher vertebrates including man. With respect to nerve fiber classification, arborization pattern, topography, and organization of the microenvironment at the termination site afferent and efferent nerve terminals are differentiated. Only the dura mater and the pial subcompartment of the leptomeninx possess the morphological prerequisites for neurogenic inflammation. In the current review, the results of morphological studies regarding the meningeal innervation including the sites of CSF (cerebrospinal fluid) production and absorption are discussed with emphasis on their structure-function relationships.

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Section: Innervation Of the Leptomeninxmentioning

confidence: 97%

Nerve fibers innervating the cranial and spinal meninges: Morphology of nerve fiber terminals and their structural integration

Fricke

Andres

Düring

2001

Microscopy Res & Technique

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“…Morphological studies revealed the existence of nerve fibers supplying the mammalian cerebral arteries (Dahl et al 1965;Samarasinghe 1965;Sato 1966;Nelson and Rennels 1970a, b;Nielsen et al 1971). Furthermore, some authors suggested an innervation of the leptomeninx itself, nerve fibers designated as "nervi proprii" by Stöhr (Huber 1897;Clark 1931;Stöhr jr 1940;Krahn 1983). Cerebral arteries are supplied by different types of cerebrovascular nerve fibers containing neuropeptides and neurotransmitters such as substance P (SP), calcitonin gene-related peptide (CGRP), vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), noradrenaline, and nitric oxide (Kobayashi et al 1981; Barja et al 1983;Hara et al 1985;Matsuyama et al 1985;Liu-Chen et al 1986;Edvinsson et al 1987;Saito et al 1987;Tsai et al 1988;Suzuki 1989;Cavanagh et al 1990;Suzuki et al 1993;Tomimoto et al 1993;Loesch et al 1994;Shimizu 1994).…”

Section: Introductionmentioning

confidence: 99%

Topography and immunocytochemical characterization of nerve fibers in the leptomeningeal compartments of the rat. A light- and electron-microscopical study

Fricke

Düring

Andres

1996

Cell and Tissue Research

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The localization of peptidergic, catecholaminergic, and nitroxidergic nerve fibers in the ventral leptomeningeal connective tissue compartment was studied in whole-mount preparations and serial semithin and ultrathin sections. For immunocytochemistry, whole-mount preparations of the leptomeninges and ventral brain slices with the meninges were incubated as free-floating specimens with primary antibodies against protein gene product 9.5 (PGP 9.5), substance P (SP), calcitonin gene-related peptide (CGRP), dopamine beta-hydroxylase (DbetaH), vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), and nitric oxide synthase (NOS) using the avidin-biotin-peroxidase method. Based on the regional differences of the connective tissue organization, the leptomeninx is subdivided into the pial, trabecular, and adventitial leptomeninx. The antibody PGP 9.5 stains all unmyelinated nerve fibers in the leptomeninx. Although the highest density of nerve fibers occurs in the adventitial leptomeninx, nerve fibers, and terminals are additionally present in the trabecular and pial leptomeninx. DbetaH-, NPY-, VIP- and NOS-immunoreactive (IR) nerve fibers occur exclusively in the adventitial leptomeninx forming neuromuscular junctions. CGRP- and SP-IR nerve fibers are localized in all three leptomeningeal compartments where they terminate close to the subarachnoid space (type 1) or within the connective tissue (type 2). Due to their morphological and immunocytochemical characterization a possible chemo-, mechano- or nociceptive function is discussed in the context of pathophysiological aspects.

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“…The vessels described in these reports are not named, nor is the region of the brain surface identified from which the tissues were taken. Likewise in a recent study of the perivascular nervous plexus of subarachnoid arteries on the cat brain stem, Krahn (1983) does not indicate the presence of pigmented cells. Experimental studies of the cat meninges make no mention of melanocytes (Kubie and Schultz, 1925).…”

Section: Discussionmentioning

confidence: 70%

Pigmented cells in the leptomeninges of the cat

Morse

Cova

1984

Anat. Rec.

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Cells laden with pigment granules are described in the leptomeningeal tissues of the cat and kitten. These cells can be identified consistently by gross observation following vascular perfusion. The fusiform or stellate pigmented cells are most often found in association with the outermost layers of the arteries of the subarachnoid space. They are typically separated from the cerebrospinal fluid by an attenuated layer of pial cells. Vessels that are described as having pigmented cells along their course are the anterior and posterior cerebellar; the anterior, middle, and posterior cerebral; and the basilar. Electron microscopic studies confirm the presence of abundant pigment granules. The pigment granules are the predominant component of the cytoplasm. Few organelles are demonstrable except for a large central nucleus. The data provide support for the concept of neural crest contribution to leptomeningeal structures. Identification of this isolated, easily defined population of melanocytes may provide a model for further studies of neural crest distribution as well as experimental approaches to melanogenesis and melanoma production and control.

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Nerve Sheaths in the Leptomeningeal Connective Tissue

Cited by 4 publications

References 13 publications

Nerve fibers innervating the cranial and spinal meninges: Morphology of nerve fiber terminals and their structural integration

Nerve fibers innervating the cranial and spinal meninges: Morphology of nerve fiber terminals and their structural integration

Topography and immunocytochemical characterization of nerve fibers in the leptomeningeal compartments of the rat. A light- and electron-microscopical study

Pigmented cells in the leptomeninges of the cat

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