Nerve sheath myxoma of the oral cavity: a distinct entity

Bartake, Anirudha; Palaskar, Sangeeta; Narang, Bindiya; Kathuriya, Pargatsingh

doi:10.1080/02688697.2017.1301379

Cited by 4 publications

(6 citation statements)

References 9 publications

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“…NSM usually arises from the small peripheral nerves, and the involvement of the oral mucosa is rare 44,45 . NSM is characterized by a myxoid tissue organized in nodules of varying shape and size.…”

Section: Discussionmentioning

confidence: 99%

“…NSM usually arises from the small peripheral nerves, and the involvement of the oral mucosa is rare. 44,45 NSM is characterized by a myxoid tissue organized in nodules of varying shape and size. The myxoid nodules are typically hypocellular with an abundance of Alcian blue-positive ground substance, 44 resembling, in parts, OFM.…”

Section: F I G U R E 2 Macroscopic Appearance Of Oral Focal Mucinosismentioning

confidence: 99%

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Oral focal mucinosis: A multi‐institutional study and literature review

et al. 2020

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Background: Oral focal mucinosis (OFM) is a rare benign condition of unknown etiology, considered the oral counterpart of cutaneous focal mucinosis. We report the clinicopathologic features of 21 cases of OFM in conjunction with a review of the literature. Methods: Clinical data were collected from the records of five oral and maxillofacial pathology services. All cases were evaluated by hematoxylin and eosin staining, histochemistry, and immunohistochemistry (vimentin, S-100, α-SMA, CD34, and mast cell). Results: The series comprised 14 females (66.7%) and seven males (33.3%), with a mean age of 48.2 ± 20.7 years (range: 8-77 years) and a 2:1 female-to-male ratio. Most of the lesions affected the gingiva (n = 6, 28.6%) and presented clinically as asymptomatic sessile or pedunculated nodules with fibrous or hyperplasic appearance. All cases were negative for S-100 protein, CD34, and α-SMA and positive for Alcian blue staining. Conservative surgical excision was the treatment in all cases, and there was only one recurrence. Conclusion: OFM is a rare benign disorder that is often clinically misdiagnosed as reactive lesions or benign proliferative processes. Dermatologists and pathologists should consider OFM in the differential diagnosis of soft tissue lesions in the oral cavity, mainly located in the gingiva. K E Y W O R D S connective tissue diseases, diagnosis, oral focal mucinosis, oral pathology 1 | INTRODUCTION Oral focal mucinosis (OFM) is considered to be the oral counterpart of cutaneous focal mucinosis (CFM) that likely develops due to an overproduction of hyaluronic acid by fibroblasts. 1-3 As a result, a well-demarcated myxomatous tissue positive for Alcian blue (pH 2.5) is observed microscopically; which may mimic other oral myxoid lesions, such as soft-tissue myxoma, fibrous hyperplasia with myxoid degeneration, nerve sheath myxoma (NSM), myxoid neurofibroma, and mucocele. 1

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Section: Discussionmentioning

confidence: 99%

Section: F I G U R E 2 Macroscopic Appearance Of Oral Focal Mucinosismentioning

confidence: 99%

Oral focal mucinosis: A multi‐institutional study and literature review

et al. 2020

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“…Immunohistochemically, neurothekeomas are positive for EMA and are negative for S-100 and GFAP and their most favored sites include head and neck, where it presents as a solitary mass. [6]…”

Section: Discussionmentioning

confidence: 99%

Nerve sheath myxoma of scalp: A rare site of presentation

et al. 2019

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Nerve sheath myxoma, a superficial myxoid tumor, was first described in 1969 by Harkin and Reed. Tumor has cytological and histological resemblance with neurothekeoma, another cutaneous myxoid lesion. Nerve sheath myxoma affects individuals of all age groups and equal predilection for both genders with most favored sites being the fingers and knee. Here, we present a case report of nerve sheath myxoma of the scalp, diagnosed and confirmed with histopathology and immunohistochemistry.

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“…Intraoral NSM is a rare benign tumor, first reported in 1974 [4], with a small additional number of cases reported to date [1,3,[5][6][7][8][9][10][11][12][13][14]. In 1980, Gallager and Helwig [15] introduced the term neurothekeoma to describe a superficial tumor of presumed nerve sheath derivation which exhibited many clinical and histological similarities to NSM [1].…”

Section: Discussionmentioning

confidence: 99%

“…A systematic review published in 2013 identified only 25 clearly documented intraoral cases of NSMs [1]. Since that publication, to the best of our knowledge, only two additional cases of intraoral NSM have been published [2,3]. Given the extreme rarity of this intraoral tumor, the aim of this study was to present a case of NSM affecting the tongue in a 43-year-old female.…”

Section: Introductionmentioning

confidence: 99%