Nerve sheath myxoma (neurothekeoma) arising in the oral cavity: histological and immunohistochemical features of 3 cases

Nishioka, Mai; Aguirre, Rodelio L.; Ishikawa, Ayataka; Nagumo, K; Wang, Lihong; Okada, Norihiko

doi:10.1016/j.tripleo.2009.01.018

Cited by 24 publications

(29 citation statements)

References 23 publications

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“…That cellular lesion was both S100 and NSE positive. The other two cases reported by Nishioka et al [3] were of classic and mixed variants and all showed the same S100 and NSE immunoprofile.…”

Section: Discussionmentioning

confidence: 64%

“…Penarrocha [4] and Nishioka et al [3] reported two mixed-type cases, which were positive for both S100 and NSE. The diagnosis of the cellular variant was given for one of the three oral cases reported by Nishioka et al [3]. That cellular lesion was both S100 and NSE positive.…”

Section: Discussionmentioning

confidence: 97%

“…Schortinghuis [5] reported a myxoid case of nerve sheath myxoma which was negative for S100 while the myxoid NSM cases reported by Nishioka [3] and Makino [9] were S100 and NSE positive. Penarrocha [4] and Nishioka et al [3] reported two mixed-type cases, which were positive for both S100 and NSE. The diagnosis of the cellular variant was given for one of the three oral cases reported by Nishioka et al [3].…”

Section: Discussionmentioning

confidence: 98%

“…Nishioka et al, reported only three oral cases of neurothekeoma out of 12,635 diagnosed cases contained in their archives [3]. Reviewing the literature, NSM has not been reported in oral locations other than tongue, buccal mucosa, palate, lip and retromolar pad.…”

Section: Discussionmentioning

confidence: 99%

“…In 1980 Gallagher and Helwig used the term neurothekeoma to describe the same tumor [2]. Although the lesion is often located in the dermis and subcutaneous tissues of the head and neck region it is rarely seen intraorally [3]. A computer assisted PubMedÒ search revealed only 23 reported intraoral cases of NSM.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Nerve Sheath Myxoma (Neurothekeoma) of the Gingiva, A Case Report and Review of the Literature

Safadi

Hellstein

Diab

et al. 2010

Head and Neck Pathol

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Nerve sheath myxoma (NSM) is a benign peripheral nerve sheath tumor that rarely occurs in the oral cavity. Among the 23 reported intraoral cases, no lesion has previously been reported on the gingiva. In this report, we describe the first gingival case of oral neurothekeoma with histopathologic and immunohistochemical characteristics. The patient, a 32 year old female presented with a slowly growing gingival mass diagnosed clinically as an epulis. The lesion was surgically excised. Histopathologically, the lesion presented as a submucosal multinodular mass composed of spindle and stellate-shaped cells with a myxoid background. Immunohistochemically, the tumor cells were sporadically positive for S-100 and NSE and negative for GFAP, EMA, SMA, CD68 and HMB45. The immunoprofile of this lesion confirmed a Schwann cell origin. The lesion was followed up for 10 months with no reports of recurrence.

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Section: Discussionmentioning

confidence: 64%