Nerve repair using a polyglactin tube and nerve graft: An experimental study in the rabbit

Molander, H.; Engkvist, Ove; Hägglund, Jarl V.; Olsson, Yngve; TorebjöPkt, Erik

doi:10.1016/0142-9612(83)90027-3

Cited by 74 publications

(23 citation statements)

References 14 publications

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“…At 16 weeks, small regenerated fascicles were seen in the center of the nerve cable surrounded by perineurial cells and remyelination of the axons was apparent. Similar results of nerve regeneration through gaps bridged with copolymer grafts of polyglycolic acid and polylactic acid were reported by Molander et al (1983). Nyilas et al (1983) used poly(L-(+)-lactic acid) (PLLA) and poly(D,L-lactic acid) (PDLA) as nerve guides to repair severed mice sciatic nerves.…”

Section: Nerve Bridge Technique Used To Repair Short Gapssupporting

confidence: 64%

Development of a Multiple-Lumen Nerve Cuff Utilizing Growth Stimulant Patterns for Controlled Regeneration

et al. 1998

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This manuscript has been reproduced from the microfilm master. UMI films the text directly from the original or copy submitted. Thus, some thesis and dissertation copies are in typewriter face, while others may be from any type of computer printer. In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion.Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand comer and continuing from left to right in equal sections with small overlaps. Each original is also photographed in one exposure and is included in reduced form at the back of the book.

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Section: Nerve Bridge Technique Used To Repair Short Gapssupporting

confidence: 64%

Development of a Multiple-Lumen Nerve Cuff Utilizing Growth Stimulant Patterns for Controlled Regeneration

et al. 1998

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“…A variety of biological and artificial nerve conduits have been widely reported in experimental models. Artificial conduits made of silicone, [13][14][15][16] collagen, [17][18][19][20] polyglactin, 21 poly-L-lactic acid (PLLA), 22 polyglycolic acid (PGA), [23][24][25] or some combination 26,27 have been reported.…”

mentioning

confidence: 99%

A Comparison of Polyglycolic Acid Versus Type 1 Collagen Bioabsorbable Nerve Conduits in a Rat Model: An Alternative to Autografting

Waitayawinyu

Parisi

Miller

et al. 2007

The Journal of Hand Surgery

104

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“…A comparison of tubes made of two biodurable polymers, silicone and poly(tetrafluorethylene), and two degradable polymers, a copolymer of poly-(lactic acid) and Â-caprolactone, as well as collagen [Navarro et al, 1996], indicated that the degradable tubes induced a higher quality of regeneration compared to the biodurable tubes over a 6 mm gap in the mouse sciatic nerve. A number of degradable tubes have additionally been shown to perform as well as the autograft, considered to be clearly superior to regeneration observed with a silicone tube and commonly thought to fall short only of the normal nerve in function [Molander et al, 1983;Archibald et al, 1991Archibald et al, , 1995Robinson et al, 1991;den Dunnen et al, 1996;.…”

Section: Introductionmentioning

confidence: 99%

Optimal Degradation Rate for Collagen Chambers Used for Regeneration of Peripheral Nerves over Long Gaps

Harley

Spilker

et al. 2004

Cells Tissues Organs

116

106

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The experimental study of peripheral nerve regeneration has depended heavily on the use of a nerve chamber in which the stumps of the transected nerve are inserted. A large variety of chamber fillings and chamber types have been used in an effort to induce a higher quality of regeneration across the gap initially separating the two stumps. In this study we studied the morphology of nerves regenerated across a 15 mm gap following implantation of a series of five chambers. The chambers were fabricated from type I collagen and possessed identical pore volume fractions as well as average pore diameters, but differed in cross-link density continuously along the series. The residual mass of the implanted chambers at 9 weeks was observed to increase continuously with increasing cross-link density along the series, indicating a continuous decrease in degradation rate. The quality of regenerated nerves, determined by the number of large diameter fibers (A-fibers) per nerve, the average diameter of all axons and the ratio of area occupied by axons (N-Ratio), was superior at an intermediate level of chamber degradation rate. The maximal quality of peripheral nerve regeneration corresponded to an optimal degradation rate with an estimated chamber half-life of approximately 2–3 weeks following implantation. A speculative mechanistic explanation of the observed optimum focuses on the hypothetical role of cell and cytokine traffic that may take place through holes in the chamber generated by the degradation process. The data show the presence of a hitherto unreported optimal chamber degradation rate that leads to regenerated nerves of maximum quality.

show abstract

Nerve repair using a polyglactin tube and nerve graft: An experimental study in the rabbit

Cited by 74 publications

References 14 publications

Development of a Multiple-Lumen Nerve Cuff Utilizing Growth Stimulant Patterns for Controlled Regeneration

Development of a Multiple-Lumen Nerve Cuff Utilizing Growth Stimulant Patterns for Controlled Regeneration

A Comparison of Polyglycolic Acid Versus Type 1 Collagen Bioabsorbable Nerve Conduits in a Rat Model: An Alternative to Autografting

Optimal Degradation Rate for Collagen Chambers Used for Regeneration of Peripheral Nerves over Long Gaps

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