Nerve pathology of microangiopathy and thromboinflammation in hereditary transthyretin amyloidosis
Shin‐Joe Yeh,
Ti‐Yen Yeh,
Yi‐Shiang Wang
et al.
Abstract:ObjectiveDespite amyloid deposition as a hallmark of hereditary transthyretin amyloidosis (ATTRv) with polyneuropathy, this pathology could not completely account for nerve degeneration. ATTRv patients frequently have vasomotor symptoms, but microangiopathy hypothesis in ATTRv was not systemically clarified.MethodsThis study examined the vascular pathology of sural nerves in ATTRv patients with transthyretin (TTR) mutation of p.Ala117Ser (TTR‐A97S), focusing on morphometry and patterns of molecular expression … Show more
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