Nerve injury associated with high‐intensity focused ultrasound: A case report

Sathaworawong, Angkana; Wanitphakdeedecha, Rungsima

doi:10.1111/jocd.12464

Cited by 10 publications

(11 citation statements)

References 16 publications

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“…Nerve injury, one of the most important side effects of HIFU treatment, is caused by local heat delivered deep into the superficial musculoaponeurotic system. Areas where the facial nerve branches lie superficially (pre‐auricular or perioral areas) are at higher risk of nerve injury 2,19–21 . In our study of 102 participants, no neurological AEs including nerve injury or numbness were reported, which is also a significantly lower frequency than the previous study results 2 …”

Section: Discussioncontrasting

confidence: 55%

“…Areas where the facial nerve branches lie superficially (pre-auricular or perioral areas) are at higher risk of nerve injury. 2,[19][20][21] In our study of 102 participants, no neurological AEs including nerve injury or numbness were reported, which is also a significantly lower frequency than the previous study results. 2 Other than neurologic complications, the most common AEs are erythema, pain, bruising, or oedema, linear striations/wheals, pigmentary changes, or fat atrophy have been reported.…”

Section: Discussionmentioning

confidence: 61%

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Safety and efficacy of high‐intensity focused ultrasound for treatment of periorbital, perioral, and neck wrinkles: Prospective open single‐center single‐arm confirmatory clinical trial

Han

Park

Kim³

et al. 2022

Dermatologic Therapy

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Periorbital, perioral, and neck wrinkles are one of the most common concerns of aging skin. We evaluated the efficacy and safety of high‐intensity focused ultrasound (HIFU) device with a 5.5‐MHz transducer and a 2.0‐mm focal depth for improving periorbital, perioral, and neck wrinkles. A total of 102 participants were enrolled, and 34 each were assigned to the periorbital, perioral, and neck groups. All subjects were treated with HIFU three times at 2‐week intervals at the corresponding treatment site. Objective measurements and clinical evaluations were performed at 10 and 16 weeks after treatment. Based on the primary efficacy evaluation, the mean Cutometer R7 value was significantly increased at 10 weeks post‐treatment compared to baseline in all treated groups. In addition, all other Cutometer values, PRIMOS and Antera 3D camera evaluation results, classification of wrinkle assessment results, and Subject Global Aesthetic Improvement Scale also showed that the periorbital, perioral, and neck wrinkles were significantly improved at 10 and 16 weeks post‐treatment. No permanent adverse effects were observed during the follow‐up period. HIFU treatment using 5.5‐MHz transducers (2.0‐mm focal depth) could be an effective and safe treatment modality for the treatment of periorbital, perioral, and neck wrinkles.

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Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 61%

Safety and efficacy of high‐intensity focused ultrasound for treatment of periorbital, perioral, and neck wrinkles: Prospective open single‐center single‐arm confirmatory clinical trial

Han

Park

Kim³

et al. 2022

Dermatologic Therapy

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“…Facial nerve damage may also occur as a complication of aesthetic procedures: • HIFU (high-intensity focused ultrasound) -a treatment used to lift the face, uses a focused beam of sound waves with a large range [7], • injection of botulinum toxin [8].…”

Section: Causes and Symptoms Of Facial Nerve Palsymentioning

confidence: 99%

Review of physical methods in the treatment of Bell’s palsy

Stryła¹,

Kaczmarek²

2021

Aesth Cosmetol Med

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Peripheral facial nerve damage is the most common condition of all cranial nerve damage; this nerve innervates the face in motor, sensory and parasympathetic ways. Bell’s palsy prevents patients from functioning normally by disturbing the speech function, eating and facial expressions. It can also lead to severe infl ammation of the eyeball and consequently to blindness. The study focuses on the influence of appropriately selected physical procedures on the time over which facial palsy affects a patient. The use of therapeutic methods such as: electrotherapy, heat treatment, facial massage, kinesitherapy and fi llers were also presented Comprehensive rehabilitation therapy based on the cooperation of doctors, physiotherapists and cosmetologists signifi cantly improves the results of pharmacological treatment and shortens convalescence time.

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“…Apart from direct heating, HIFU, especially with high pressure (> 10 MPa), short pulse width (< 20 μs) at a low duty cycle (< 1%) [9][10], has been shown to induce inertial acoustic cavitation, in which submicron/micron-sized gas bubbles form from cavitation nuclei and collapse rapidly after growth, causing destructive mechanical damage from shock waves or high-speed microjets [11]. Although both heat and cavitation effectively destroy tumor cells, nearby normal tissue in the target area also is affected by the non-specific damage during the treatment, causing unwanted side effects, or even resulting in loss of bodily function on some critical parts of the body [12][13][14][15]. As a result, most clinical treatment with HIFU must operate under the guidance of external imaging methods [4] such as magnetic resonance imaging (MRI) [1], [5][6] or ultrasound imaging [9], greatly increasing the cost and complexity of the procedure.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Non-Thermal, Selective Cancer Treatment With High-Frequency Medium-Intensity Focused Ultrasound

Tang¹,

Chen

Zhang

et al. 2021

IEEE Access

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Focused ultrasound (FUS) has proven its efficacy in non-invasive, radiation-free cancer treatment. However, the commonly used low-frequency high intensity focused ultrasound (HIFU) destroys both cancerous and healthy tissues non-specifically through extreme heat and inertial cavitation with low spatial resolution. To address this issue, we evaluate the therapeutic effects of pulsed (60 Hz pulse repetition frequency, 1.45 ms pulse width) high-frequency (20.7 MHz) medium-intensity (spatial-peak pulse-average intensity ISPPA < 279.1 W/cm , spatial-peak temporal-average intensity ISPTA < 24.3 W/cm 2 ) focused ultrasound (pHFMIFU) for selective cancer treatment without thermal damage and with low risk of inertial cavitation (mechanical index < 0.66), in an in vivo subcutaneous B16F10 melanoma tumor growth model in mice. The pHFMIFU with 104 μm focal diameter is generated by a microfabricated self-focusing acoustic transducer (SFAT) with a Fresnel acoustic lens. A three-axis positioning system has been developed for automatic scanning of the transducer to cover a larger treatment volume, while a water-cooling system is custom-built for dissipating non-acoustic heat from the transducer surface. Initial testing revealed that pHFMIFU treatment can be applied to a living animal while maintaining skin temperature under 35.6 °C without damaging normal skin and tissue. After eleven days of treatment with pHFMIFU, the treated tumors were significantly smaller with large areas of necrosis and apoptosis in the treatment field compared to untreated controls. Potential mechanisms of this selective, non-thermal killing effect, as well as possible causes of and solutions to the variation in treatment results, have been analyzed and proposed. The pHFMIFU could potentially be used as a new therapeutic modality for safer cancer treatment especially in critical body regions, due to its cancer-specific effects and high spatial resolution.INDEX TERMS High-frequency focused ultrasound, in vivo experiment, non-invasive therapy, selective cancer treatment, self-focusing acoustic transducers (SFAT), ultrasound therapy. * The average density of soft tissues [37] ** From measurement (described in Appendix B) *** Used the values for water [38] due to similar acoustic properties

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Nerve injury associated with high‐intensity focused ultrasound: A case report

Cited by 10 publications

References 16 publications

Safety and efficacy of high‐intensity focused ultrasound for treatment of periorbital, perioral, and neck wrinkles: Prospective open single‐center single‐arm confirmatory clinical trial

Safety and efficacy of high‐intensity focused ultrasound for treatment of periorbital, perioral, and neck wrinkles: Prospective open single‐center single‐arm confirmatory clinical trial

Review of physical methods in the treatment of Bell’s palsy

In Vivo Non-Thermal, Selective Cancer Treatment With High-Frequency Medium-Intensity Focused Ultrasound

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