Nerve Growth Factor Promotes Retinal Neurovascular Unit Repair: A Review

Li, Baohua; Ning, Bobiao; Yang, Fan; Guo, Chengwei

doi:10.1080/02713683.2022.2055084

Cited by 7 publications

(5 citation statements)

References 123 publications

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“…However, retinal microvessels are distributed from the NFL to the INL and are not present in the ONL. In this study, we looked at the functional impairment of the retinal NVU in DM patients, so we investigated the quantitative analysis of OCT and OCTA from the retinal NFL to the INL [ 8 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…The retinal microvasculature provides nutrients and oxygen to the NVU and excretes waste products to meet the high demand for oxygen consumption by the retina, a metabolically active neurovascular tissue [ 30 , 31 ]. Nerve and glial cell lesions can affect the microvasculature, and microvascular lesions can similarly involve the glia [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have shown that retinal neurodegeneration may precede microaneurysms [ 7 ]. Therefore, the understanding of DR has shifted from simple microvascular injury to the imbalance of neurovascular unit (NVU) injury and its coupling mechanism [ 8 ]. The structure of the NVU consists of retinal neurons, glial cells, and the retinal microvascular system, which are distributed in the corresponding 10 layers of the retina.…”

Section: Introductionmentioning

confidence: 99%

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Early diagnosis of retinal neurovascular injury in diabetic patients without retinopathy by quantitative analysis of OCT and OCTA

Chen

et al. 2023

Acta Diabetol

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Aims To quantitatively analyze and compare the differences in retinal neurovascular units (NVUs) between healthy individuals and patients with type 2 diabetes mellitus (DM) by optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) techniques and to determine the value of this technique for the early diagnosis of retinal neurovascular damage in patients with diabetes mellitus without retinopathy (NDR). Methods This observational case‒control study was conducted from July 1, 2022, to November 30, 2022, at the outpatient ophthalmology clinic of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine. All subjects underwent baseline data entry and mean thickness of the peripapillary retinal nerve fiber layer (pRNFL), the thickness of each retinal layer in the macula 3 × 3 mm, and vascular density (VD) examination. Results The study included 35 healthy individuals and 48 patients with DM. The retinal VD as well as partial pRNFL, macular nerve fiber layer (NFL), and macular ganglion cell layer (GCL) thickness in DM patients exhibited significantly lower VD in the DM group than in the control group (p < 0.05). Age and disease duration of DM patients showed a negative trend with pRNFL thickness, macular NFL thickness, macular GCL thickness, and VD. However, a positive trend was observed between DM duration and partial inner nuclear layer (INL) thickness. Moreover, there was a positive correlation between macular NFL and GCL thickness and VD for the most part, while a negative correlation was shown between INL temporal thickness and DVC-VD. pRNFL-TI and GCL-superior thickness were screened as two variables in the analysis of the predictors of retinal damage in DM according to the presence or absence of DM. The AUCs were 0.765 and 0.673, respectively. By combining the two indicators for diagnosis, the model predicted prognosis with an AUC of 0.831. In the analysis of retinal damage indicators associated with the duration of DM, after regression logistic analysis according to the duration of DM within 5 years and more than 5 years, the model incorporated two indicators, DVC-VD and pRNFL-N thickness, and the AUCs were 0.764 and 0.852, respectively. Combining the two indicators for diagnosis, the AUC reached 0.925. Conclusions Retinal NVU may have been compromised in patients with DM without retinopathy. Basic clinical information and rapid noninvasive OCT and OCTA techniques are useful for the quantitative assessment of retinal NVU prognosis in patients with DM without retinopathy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Early diagnosis of retinal neurovascular injury in diabetic patients without retinopathy by quantitative analysis of OCT and OCTA

Chen

et al. 2023

Acta Diabetol

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“…Correspondingly, NGF receptors are expressed in these structures as well as in photoreceptors ( Chakrabarti et al, 1990 ). Experimental investigations underscore the significance of NGF in promoting the survival and development of RGCs through its role as a local paracrine and autocrine mediator ( Colafrancesco et al, 2011 ; Allen et al, 2013 ; Garcia et al, 2014 ; Roberti et al, 2014 ; Wang et al, 2014 ; Aloe et al, 2015 ; Chen Q. et al, 2015 ; Mallone et al, 2020 ; Li et al, 2022 ; Lin et al, 2022 ). NGF is delivered retrogradely along the axons of RGCs ( Dias et al, 2022 ).…”

Section: Molecular Mechanisms Of Glaucoma Developmentmentioning

confidence: 99%

Molecular pathways in experimental glaucoma models

Bugara,

Pacwa,

Smedowski

2024

Front. Neurosci.

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Glaucoma is a complex and progressive disease that primarily affects the optic nerve axons, leading to irreversible vision loss. Although the exact molecular mechanisms underlying glaucoma pathogenesis are not fully understood, it is believed that except increased intraocular pressure, a combination of genetic and environmental factors play a role in the development of the disease. Animal models have been widely used in the study of glaucoma, allowing researchers to better understand the underlying mechanisms of the disease and test potential treatments. Several molecular pathways have been implicated in the pathogenesis of glaucoma, including oxidative stress, inflammation, and excitotoxic-induced neurodegeneration. This review summarizes the most important knowledge about molecular mechanisms involved in the glaucoma development. Although much research has been done to better understand the molecular mechanisms underlying this disease, there is still much to be learned to develop effective treatments and prevent vision loss in those affected by glaucoma.

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“…Nerve growth factor (NGF) is another type of neuroprotective agent that acts on the central and peripheral neurons and the visual system [ 204 , 205 ]. Treatment of PC12 cell line with NGF eye drops has shown to downregulate Bax expression and increase Bcl-2 expression [ 206 ].…”

Section: Novel Therapeutic Targets In Preclinical Phase: Neuroprotect...mentioning

confidence: 99%

Retinitis Pigmentosa: Novel Therapeutic Targets and Drug Development

Kulbay

Toameh

et al. 2023

Pharmaceutics

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Retinitis pigmentosa (RP) is a heterogeneous group of hereditary diseases characterized by progressive degeneration of retinal photoreceptors leading to progressive visual decline. It is the most common type of inherited retinal dystrophy and has a high burden on both patients and society. This condition causes gradual loss of vision, with its typical manifestations including nyctalopia, concentric visual field loss, and ultimately bilateral central vision loss. It is one of the leading causes of visual disability and blindness in people under 60 years old and affects over 1.5 million people worldwide. There is currently no curative treatment for people with RP, and only a small group of patients with confirmed RPE65 mutations are eligible to receive the only gene therapy on the market: voretigene neparvovec. The current therapeutic armamentarium is limited to retinoids, vitamin A supplements, protection from sunlight, visual aids, and medical and surgical interventions to treat ophthalmic comorbidities, which only aim to slow down the progression of the disease. Considering such a limited therapeutic landscape, there is an urgent need for developing new and individualized therapeutic modalities targeting retinal degeneration. Although the heterogeneity of gene mutations involved in RP makes its target treatment development difficult, recent fundamental studies showed promising progress in elucidation of the photoreceptor degeneration mechanism. The discovery of novel molecule therapeutics that can selectively target specific receptors or specific pathways will serve as a solid foundation for advanced drug development. This article is a review of recent progress in novel treatment of RP focusing on preclinical stage fundamental research on molecular targets, which will serve as a starting point for advanced drug development. We will review the alterations in the molecular pathways involved in the development of RP, mainly those regarding endoplasmic reticulum (ER) stress and apoptotic pathways, maintenance of the redox balance, and genomic stability. We will then discuss the therapeutic approaches under development, such as gene and cell therapy, as well as the recent literature identifying novel potential drug targets for RP.

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Nerve Growth Factor Promotes Retinal Neurovascular Unit Repair: A Review

Cited by 7 publications

References 123 publications

Early diagnosis of retinal neurovascular injury in diabetic patients without retinopathy by quantitative analysis of OCT and OCTA

Early diagnosis of retinal neurovascular injury in diabetic patients without retinopathy by quantitative analysis of OCT and OCTA

Molecular pathways in experimental glaucoma models

Retinitis Pigmentosa: Novel Therapeutic Targets and Drug Development

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