Nerve growth factor promote osteogenic differentiation of dental pulp stem cells through MEK/ERK signalling pathways
Chen Cheng,
Shuai Tang,
Shuyue Cui
et al.
Abstract:Nerve growth factor (NGF) and its receptor, tropomyosin receptor kinase A (TrkA), are known to play important roles in the immune and nervous system. However, the effects of NGF on the osteogenic differentiation of dental pulp stem cells (DPSCs) remain unclear. This study aimed to investigate the role of NGF on the osteogenic differentiation of DPSCs in vitro and the underlying mechanisms. DPSCs were cultured in osteogenic differentiation medium containing NGF (50 ng/mL) for 7 days. Then osteogenic‐related gen… Show more
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