Nerve growth factor induces proliferation and enhances fiber regeneration in oligodendrocytes isolated from adult pig brain

Althaus, Hans H.; Klöppner, Sabine; Schmidt-Schultz, Tyede H.; Schwartz, Peter J.

doi:10.1016/0304-3940(92)90440-i

Cited by 83 publications

(71 citation statements)

References 17 publications

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“…However, there is some evidence that a select sub-population of mature OL can be induced to proliferate. For instance, Althaus et al were able to induce proliferation of a sub-set of mature OL using nerve growth factor (NGF) treatment, and subsequently showed that NGF treatment can activate ERK1 in OL (Althaus et al, 1992(Althaus et al, , 1997. Furthermore, the complement complex C5b-9 has also been shown to increase both mature OL proliferation and ERK1 activation (Rus et al, 1997).…”

Section: Mature Olmentioning

confidence: 99%

Mitogen‐activated protein kinase signalling in oligodendrocytes: a comparison of primary cultures and CG‐4

Stariha¹,

Kim²

2001

Intl J of Devlp Neuroscience

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Oligodendrocytes play a significant role in the central nervous system, as these cells are responsible for myelinating axons and allowing for the efficient conduction of nerve impulses. Therefore, any understanding we can gain about the functional biology of oligodendrocytes will give us important insights into demyelinating diseases such as multiple sclerosis, where oligodendrocytes and myelin are damaged or destroyed. Currently, much attention has focussed on the role of a family of mitogen-activated protein kinases in OL. This kinase family includes the extracellular signal-regulated protein kinases (ERKs), the stress-activated c-Jun N-terminal kinase (JNK), and the 38 kDa high osmolarity glycerol response kinase (p38). The actions of mitogen-activated protein kinases in oligodendrocytes appear to range from proliferation and cell survival to differentiation and cell death. In the past, studies on oligodendrocytes have been hampered by the difficulties inherent in producing large enough quantities of these cells for experimentation. This problem arises in large part due to the post-mitotic nature of mature oligodendrocytes. Over the years, a cell line known as Central Glia-4 (CG-4) has become a popular oligodendrocyte model due to its potentially unlimited capacity for self-renewal. In this review, we will look at the suitability of the Central Glia-4 cell line as an oligodendrocyte model, specifically in respect to studies on mitogen-activated protein kinase signalling in oligodendrocytes.

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Section: Mature Olmentioning

confidence: 99%

Mitogen‐activated protein kinase signalling in oligodendrocytes: a comparison of primary cultures and CG‐4

Stariha¹,

Kim²

2001

Intl J of Devlp Neuroscience

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“…Under these culture conditions, oligodendrocytes continue to express high levels of p75. E xpression of TrkA receptors in oligodendroglial cultures, however, has been reported (Althaus et al, 1992;Cohen et al, 1996). Indeed, when we expand oligodendrocyte progenitors with basic FGF (bFGF) and PDGF before differentiation conditions (Raff et al, 1988;McKinnon et al, 1990), TrkA expression could be detected in mature oligodendrocytes by RT-PCR analysis (Fig.…”

Section: O1mentioning

confidence: 99%

Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival

et al. 1998

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In addition to its role as a survival factor, nerve growth factor (NGF) has been implicated in initiating apoptosis in restricted cell types both during development and after terminal cell differentiation. NGF binds to the TrkA tyrosine kinase and the p75 neurotrophin receptor, a member of the tumor necrosis factor cytokine family. To understand the mechanisms underlying survival versus death decisions, the TrkA receptor was introduced into oligodendrocyte cell cultures that undergo apoptosis in a p75-dependent manner. Here we report that activation of the TrkA NGF receptor in oligodendrocytes negates cell death by the p75 receptor. TrkA-mediated rescue from apoptosis correlated with mitogen-activated protein kinase activation. Concurrently, activation of TrkA in oligodendrocytes resulted in suppression of c-jun kinase activity initiated by p75, whereas induction of NFB activity by p75 was unaffected. These results indicate that TrkA-mediated rescue involves not only activation of survival signals but also simultaneous suppression of a death signal by p75. The selective interplay between tyrosine kinase and cytokine receptors provides a novel mechanism that achieves alternative cellular responses by merging signals from different ligand-receptor systems.

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“…Culture studies suggest that neurotrophins influence oligodendrocyte function by affecting proliferation of progenitors [8,9], survival of progenitors [10] and postmitotic cells [11,12] and differentiation [13,14]. However, the roles of individual neurotrophins vary in different reports and the literature has been confusing.…”

Section: Introductionmentioning

confidence: 99%

Regionally Specific Effects of BDNF on Oligodendrocytes

et al. 2003

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To define the effects of neurotrophins on oligodendrocytes, we monitored NGF, BDNF and NT-3 actions on basal forebrain (BF) and cortical populations. NGF, BDNF and NT-3 applied to BF oligodendrocytes elicited increases in expression of myelin basic protein (MBP) and enhanced the numbers of MBP+ cells, without affecting total cell numbers. In the cortex, however, while NGF and NT-3 influenced MBP expression, BDNF was without effect. To explore this apparent regional difference in BDNF action, we compared expression of the neurotrophin receptors trkA, trkB and trkC. While BF cells expressed all three trks, cortical cells did not express the full-length BDNF receptor, trkB. Interestingly, in no case was any receptor expressed by all oligodendrocytes, indicating that oligodendrocytes may be heterogeneous within a brain region. The data suggest that BF oligodendrocytes are influenced by BDNF to express MBP and are distinct in this ability from cortical cells.

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Nerve growth factor induces proliferation and enhances fiber regeneration in oligodendrocytes isolated from adult pig brain

Cited by 83 publications

References 17 publications

Mitogen‐activated protein kinase signalling in oligodendrocytes: a comparison of primary cultures and CG‐4

Mitogen‐activated protein kinase signalling in oligodendrocytes: a comparison of primary cultures and CG‐4

Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival

Regionally Specific Effects of BDNF on Oligodendrocytes

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