Nerve growth factor in metabolic complications and Alzheimer's disease: Physiology and therapeutic potential

Ding, Xiao-Wen; Li, Rongzi; Geetha, Thangiah; Tao, Ya‐Xiong; Babu, Jeganathan Ramesh

doi:10.1016/j.bbadis.2020.165858

Cited by 21 publications

(18 citation statements)

References 210 publications

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“… 10 It has been suggested that NGF can be involved in cellular function by initiating phosphorylation of the protein cascade. 38 NGF can also affect some metabolic conditions such as diabetes, obesity and MetS. 38 Inconsistencies between findings of different studies is probably due to the different health/disease status in their participants.…”

Section: Discussionmentioning

confidence: 99%

“… 38 NGF can also affect some metabolic conditions such as diabetes, obesity and MetS. 38 Inconsistencies between findings of different studies is probably due to the different health/disease status in their participants. 9 …”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, NGF has structural homology with proinsulin. 38 Also, pancreatic β cells synthesized and secreted NGF similar to insulin. NGF has role in fine -tuning insulin secretion.…”

Section: Discussionmentioning

confidence: 99%

“… 38 Experimental studies showed that NGF can promote glucose-simulated insulin secretion via receptor-mediated intracellular pathways. 38 So, this can justify the regulatory role of NGF in insulin secretion and subsequent metabolism such as glucose and lipid metabolism. But finding the exact mechanism of this hypothesis needs more detailed studies.…”

Section: Discussionmentioning

confidence: 99%

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Investigation of the association between cardio-metabolic risk factors, neurotrophins and gastric hormones among apparently healthy women: A cross-sectional analysis

Zeinalian

Moghadam

Pahlavani

et al. 2022

J Cardiovasc Thorac Res

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Introduction: Although, some evidence has shown that obestatin, ghrelin, and neurotrophic factors can be involved in the development of cardio-metabolic risk factors, there are some contradictions in this regard. We aimed to investigate the association of serum neurotrophic factors and some gastric hormones with cardio-metabolic risk factors among apparently healthy women. Methods: In the present study, 90 apparently healthy women were recruited by a convenient sampling method from the nutrition counseling clinic in Tabriz, Iran. All participants need dietary counseling for weight loss and were recruited before receiving any dietary interventions. Anthropometric, biochemical, physical activity, and blood pressure (BP) measurements, as well as dietary assessment, were done in all participants. Results: Women who were in the highest tertile of serum obestatin levels (OR=0.118, 95% CI:0.035-0.396) had a significantly lower risk for development of hypertriglyceridemia compared to the reference group (P trend<0.001). Participants in the highest tertile of serum ghrelin had a significant lower risk of hypertriglyceridemia, hyperglycemia, low HDL-C, and MetS (Ptrend<0.05). Women who were in the higher tertile of serum NGF levels had a significantly lower risk for development of hypertriglyceridemia after adjustment for potential confounding variables (OR=0.091, 95% CI: 0.023-0.361 and OR=0.193, 95% CI: 0.057-0.649 respectively). Conclusion: In the current study serum levels of obestatin, NGF, and ghrelin were associated with some cardio-metabolic risk factors such as hypertriglyceridemia and MetS. It seems that these factors are associated with metabolic regulation. However, further studies are needed to substantiate this claim.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Investigation of the association between cardio-metabolic risk factors, neurotrophins and gastric hormones among apparently healthy women: A cross-sectional analysis

Zeinalian

Moghadam

Pahlavani

et al. 2022

J Cardiovasc Thorac Res

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“…In the GEO database, we discovered that NGF was signi cantly decreased in AD patients. NGF, as a member of the neurotrophic factor family, has powerful effects on neuronal nurturing (29). Our previous study had reported that NGF de ciency occurred in the hippocampus of APP/PS1 mice, leading to cognitive de cits (9).…”

Section: Discussionmentioning

confidence: 99%

Cordycepin Improved Neuronal Synaptic Plasticity Through CREB-Induced NGF Up-Regulation Driven By Microglial M2 Polarization: A Symphony Communication Between Microglia and Neurons in AD

Jiao¹,

Liu²,

Zhong³

et al. 2021

Preprint

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Background: The purpose of this study was to explore the molecular mechanism of the neuroprotective effect of Cordycepin (CCS) on improving the neuro-immune microenvironment of AD neurons by mediating microglial M2 polarization. Methods: We investigated microglial M2 polarization from M1, neuronal senescence, and synaptic plasticity by biological techniques such as animal behavior, cell biology, morphology, and bioinformatics. Results: CCS improved learning and memory impairment in 9-month-old APP/PS1 mice. CCS induced the microglial M2 polarization, up-regulated the expression and secretion level of NGF, and inhibited neuronal apoptosis, senescence, and synaptic damage caused by abnormal microglial activation in vivo and in vitro. CREB was activated by the M2 polarization and mediated the NGF expression and secretion after CCS treatment. CREB bound with the Sg3 promoter region of NGF (-1018~-1011), which increased NGF expression and secretion. CREB-induced NGF upregulation driven by microglial M2 polarization to improve the neuronal synaptic plasticity inhibits neuronal apoptosis and senescence. As a novel participant in the intercellular communication between MG and neurons, NGF contributed to the neuroprotective efficacy of CCS treatment. Conclusions: CCS improved the neuronal synaptic plasticity and senescence by promoting microglial M2 activation driven by CERB-induced NGF upregulation and conducted the symphony communication of MG-Neuron in AD.

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Exploring the Mechanism ofArctium LappaL. Leaves in the Treatment of Alzheimer's Disease Based on Chemical Profile, Network Pharmacology and Molecular Docking

Xue

Qin

et al. 2023

Advanced Biology

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Alzheimer's Disease (AD) is an irreversible neurodegenerative disease, which urgently needs more effective treatment strategies. Arctium lappa L. leaf (burdock leaf) performs wide pharmacological activities, increasing evidence hinted that burdock leaves can ameliorate AD. This research aims to explore the bioactive ingredients and mechanisms of burdock leaves against AD by performing chemical profiles, network pharmacology, and molecular docking. 61 components are identified by liquid chromatography equipped with mass spectrometry. 792 targets of ingredients and 1661 AD‐related genes are retrieved from public databases. Ten critical ingredients are identified from the topology analysis of the compound‐target network. CytoNCA, AlzData database, and Aging Atlas database contribute to the foundation of 36 potential targets and four clinically significant targets (STAT3, RELA, MAPK8, and AR). The gene ontology (GO) analysis manifests that the included processes are close to the pathogenesis of AD. PI3K‐Akt signaling pathway and AGE‐RAGE signaling pathway may be important therapeutic mechanisms. Molecular docking results imply that network pharmacology results are reliable. Furthermore, the clinical meanings of core targets are also evaluated with the Gene Expression Omnibus (GEO) database. This research will provide research direction for the application of burdock leaves in the treatment of AD.

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Nerve growth factor in metabolic complications and Alzheimer's disease: Physiology and therapeutic potential

Cited by 21 publications

References 210 publications

Investigation of the association between cardio-metabolic risk factors, neurotrophins and gastric hormones among apparently healthy women: A cross-sectional analysis

Investigation of the association between cardio-metabolic risk factors, neurotrophins and gastric hormones among apparently healthy women: A cross-sectional analysis

Cordycepin Improved Neuronal Synaptic Plasticity Through CREB-Induced NGF Up-Regulation Driven By Microglial M2 Polarization: A Symphony Communication Between Microglia and Neurons in AD

Exploring the Mechanism ofArctium LappaL. Leaves in the Treatment of Alzheimer's Disease Based on Chemical Profile, Network Pharmacology and Molecular Docking

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