Nerve Growth Factor Expression after Plantar Incision in the Rat

Wu, Cong; Boustany, Leila M.; Hong, Lei; Brennan, Timothy J.

doi:10.1097/01.anes.0000267512.08619.bd

Cited by 78 publications

(64 citation statements)

References 28 publications

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“…NGF is suggested to be an important mediator in the production of inflammatory pain (Lewin and Mendell, 1993;Sah et al, 2003;Hefti et al, 2006). NGF can be released from keratinocytes, fibroblasts, Schwann cells, and mast cells in the tissues after injury or inflammation (Wu et al, 2007;Radtke et al, 2010). The interaction between NGF and its receptor tyrosine kinase A (TrkA) has been implicated in the process of ERK5 activation (Watson et al, 2001;Wang and Tournier, 2006).…”

Section: Nerve Growth Factor Has Been Implicated In the Process Of Ermentioning

confidence: 99%

Research progress of the role and mechanism of extracellular signal-regulated protein kinase 5 (ERK5) pathway in pathological pain

Sun

Wei

et al. 2016

J. Zhejiang Univ. Sci. B

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Extracellular signal-regulated protein kinase 5 (ERK5), also known as big mitogen-activated protein kinase 1 (MAPK1), is an important member of ERK family, which is a subfamily of the large MAPK family. ERK5 is expressed in many tissues, including the dorsal root ganglion (DRG) neurons and the spinal cord. In this review, we focus on elaborating ERK5-associated pathway in pathological pain, in which the ERK5/CREB (cyclic adenosine monophosphate (cAMP)-response element-binding protein) pathway plays a crucial role in the transduction of pain signal and contributes to pain hypersensitivity. ERK5 activation in the spinal dorsal horn occurs mainly in microglia. The activation of ERK5 can be mediated by N-methyl-D-aspartate (NMDA) receptors. We also elaborate the relationship between ERK5 activation and nerve growth factor-tyrosine kinase A (NGF-TrkA), and the connection between ERK5 activation and brain-derived neurotrophic factor (BDNF) in pathological pain in detail.

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Section: Nerve Growth Factor Has Been Implicated In the Process Of Ermentioning

confidence: 99%

Research progress of the role and mechanism of extracellular signal-regulated protein kinase 5 (ERK5) pathway in pathological pain

Sun

Wei

et al. 2016

J. Zhejiang Univ. Sci. B

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“…Increased expression of either NGF or its high-affinity receptor TrkA, which exacerbates pain states, is reported in inflammatory tissues, including burn-injured tissue (3,4), postoperative surgical sites (5,6), and human degenerative lumbar facet joints (7). Local injection of complete Freund's adjuvant (CFA), which is utilized for the inflammatory pain model, also increases NGF expression in the skin (8).…”

Section: Introductionmentioning

confidence: 99%

Local Administration of a Synthetic Cell-Penetrating Peptide Antagonizing TrkA Function Suppresses Inflammatory Pain in Rats

et al. 2010

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Abstract. Novel agents that inhibit nerve growth factor signaling are required for the treatment of inflammatory pain. The present study investigated the effect of local administration of inhibitory peptide of TrkA (IPTRK3), a synthetic cell-penetrating peptide that antagonizes TrkA function, in complete Freund's adjuvant (CFA)-induced hyperalgesia in rats. Three hours after subcutaneous injection of CFA into the plantar surface of the rat's left hind paw, 10 mM IPTRK3 was injected at the same site. Thermal and mechanical hyperalgesia were tested in the ipsilateral hind paw until 7 days after CFA injection. The ipsilateral dorsal root ganglion (DRG) was dissected out for immunohistochemical analysis of transient receptor potential vanilloid subfamily member 1 (TRPV1) channels and TrkA. Local injection of this peptide significantly suppressed both thermal and mechanical hyperalgesia produced by CFA and also significantly reduced TRPV1 expression at the DRG. These results suggest that local administration of IPTRK3 is likely effective in the treatment of inflammatory pain in rats.

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“…There are studies that demonstrated the involvement of proinflammatory cytokines interleukin 1β (IL-1β) and tumor necrosis factor alpha (TNF-α) 9 , and the nerve growth factor (NGF) 10 in the induction and maintenance of pain in injured peripheral tissue (as found in surgeries). These proinflammatory substances play important roles in mediating exaggerated pain conditions 11 .…”

mentioning

confidence: 99%

Ameliorative Potential of Standardized Extract of Condalia buxifolia Reissek in Attenuating the Postoperative Pain: Evidence for the Inhibition of AMPA and Kainate in the Spinal Cord

Simões¹,

Coelho²,

Zambenedetti³

et al. 2017

PBJ

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Acute pain post-surgery is one of the major problems of public health, and its treatment is still a challenge. In this study, it was investigated the analgesic effect of a standardized methanolic extract of Condalia buxifolia (MECb) (30 and 100 mg/kg, i.g.) in a plantar incision surgery (PIS) model in mice, and the possible mechanism that underlying its effect. The effect of MECb was evaluated on the hyperalgesia (mechanical, cold and heat stimuli), and in this same model, it was analyzed the effect of MECb (100 mg/kg, i.g.) on the concentration of cytokines (TNF-α, IL-1β, IL-10) and nerve growth factor (NGF) in the paw and spinal cord.Further we investigated the effects of MECb (100 mg/kg, i.g.) on the nocifensive behaviour (spontaneous pain and hyperalgesia) induced by AMPA and kainate. Moreover, the safety profile of prolonged treatment with MECb (100 and 300 mg/kg, i.g.) and involvement of C fibers sensitive to capsaicin in its effect (100 mg/kg, i.g.) was evaluated. MECb showed a marked reduction on mechanical and heat hyperalgesia, and reduced the concentrations of TNF-α, IL-1β, and NGF. The treatment with MECb prevented the nocifensive behaviour and central sensitization caused by AMPA and kainate. Moreover, the analgesic effect of MECb was not affected by the ablation of the central afferent C fibers, and it showed reduced toxicity, indicating good safety and efficacy. The current data showed, for the first time, the analgesic and anti-inflammatory effect of MECb in an animal model of postoperative pain.The results support and suggest the use of MECb as an alternative treatment and a possible source of analgesics substances to postoperative pain.

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Nerve Growth Factor Expression after Plantar Incision in the Rat

Cited by 78 publications

References 28 publications

Research progress of the role and mechanism of extracellular signal-regulated protein kinase 5 (ERK5) pathway in pathological pain

Research progress of the role and mechanism of extracellular signal-regulated protein kinase 5 (ERK5) pathway in pathological pain

Local Administration of a Synthetic Cell-Penetrating Peptide Antagonizing TrkA Function Suppresses Inflammatory Pain in Rats

Ameliorative Potential of Standardized Extract of Condalia buxifolia Reissek in Attenuating the Postoperative Pain: Evidence for the Inhibition of AMPA and Kainate in the Spinal Cord

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