Nerve growth factor: Cellular localization and regulation of synthesis

Thoenen, H.; Bandtlow, Christine E.; Heumann, Rolf; Lindholm, Dan; Meyer, Michaël; Rohrer, Hermann

doi:10.1007/bf00712909

Cited by 64 publications

(35 citation statements)

References 19 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Development 138 (22) 2003; Davies, 1998;Ernfors, 2001;Thoenen et al, 1988). Therefore, part of the survival effect on sensory neurons seen in type III Nrg1 mutant mice might, in principle, be secondary to a reduction of Schwann cell support.…”

Section: Research Articlementioning

confidence: 99%

Type III neuregulin 1 regulates pathfinding of sensory axons in the developing spinal cord and periphery

et al. 2011

View full text Add to dashboard Cite

SUMMARYSensory axons must develop appropriate connections with both central and peripheral targets. Whereas the peripheral cues have provided a classic model for neuron survival and guidance, less is known about the central cues or the coordination of central and peripheral connectivity. Here we find that type III Nrg1, in addition to its known effect on neuron survival, regulates axon pathfinding. In type III Nrg1 -/-mice, death of TrkA + nociceptive/thermoreceptive neurons was increased, and could be rescued by Bax elimination. In the Bax and type III Nrg1 double mutants, axon pathfinding abnormalities were seen for TrkA + neurons both in cutaneous peripheral targets and in spinal cord central targets. Axon guidance phenotypes in the spinal cord included penetration of axons into ventral regions from which they would normally be repelled by Sema3A. Accordingly, sensory neurons from type III Nrg1 -/-mice were unresponsive to the repellent effects of Sema3A in vitro, which might account, at least in part, for the central projection phenotype, and demonstrates an effect of type III Nrg1 on guidance cue responsiveness in neurons. Moreover, stimulation of type III Nrg1 back-signaling in cultured sensory neurons was found to regulate axonal levels of the Sema3A receptor neuropilin 1. These results reveal a molecular mechanism whereby type III Nrg1 signaling can regulate the responsiveness of neurons to a guidance cue, and show that type III Nrg1 is required for normal sensory neuron survival and axon pathfinding in both central and peripheral targets.

show abstract

Section: Research Articlementioning

confidence: 99%

Type III neuregulin 1 regulates pathfinding of sensory axons in the developing spinal cord and periphery

et al. 2011

View full text Add to dashboard Cite

show abstract

“…In the best studied case, that of nerve growth factor (NGF), a large body of evidence suggests that NGF is synthesized in and secreted by cells in target tissue, retrogradely transported by sensitive neurons after binding to specific neuronal cell surface receptors, and modulates gene expression in those neurons (for reviews see Levi-Montalcini, 1987; Thoenen et al 1988; Purves, 1988;Barde, 1989). If SlOO functions as a neurotrophic factor, then it might be possible to detect the protein in either target tissue and/or sensitive neurons.…”

Section: Introductionmentioning

confidence: 99%

S100 is present in developing chicken neurons and schwann cell and promotes motor neuron survival in vivo

et al. 1992

View full text Add to dashboard Cite

We used polyclonal antisera recognizing S100, a small acidic protein highly enriched in nervous tissue, to stain sections of embryonic chicken lumbosacral spinal cord and hindlimb. S100 immunoreactivity was detected in developing sensory neurons of the dorsal root ganglia (DRG) and motor neurons of the ventral spinal cord as early as embryonic day (E) 5, and staining persisted through hatching. In contrast, expression of S100 first became apparent in Schwann cells at E13, just before myelination, and was not detected in developing skin or muscle. Since S100 beta was present in motor and sensory neurons and is known to promote neuronal survival and neurite extension in vitro (Winningham-Major, Staecker, Barger, Coats, and Van Eldik, 1989), we tested the ability of S100 to promote neuron survival in an in ovo survival assay. Addition of S100 to chick embryos in ovo during the period of naturally occurring motor neuron cell death resulted in a significant increase in motor neuron survival, but had no effect on the in vivo survival of sensory neurons in the DRG. The findings that S100 is present in spinal motor neurons and that the addition of S100 enhances the survival of these cells in vivo are consistent with the possibility that S100 may act as a naturally occurring neuron survival factor during development.

show abstract

“…They are normally present at very low levels in the non-neuronal cells of a nerve trunk, but a local injury will initiate a local synthesis at relatively high levels. 18 Enclosure of the injury zone in a tube, leaving a gap between the ends, may contribute to local accumulation of various factors, resulting in the optimal expression of trophic and tropic mechanisms. 17 This concept encouraged many researchers to investigate ideal nerve conduits for optimum nerve regeneration.…”

Section: Discussionmentioning

confidence: 99%

Nerve regeneration through a healthy peripheral nerve trunk as a nerve conduit: A preliminary study of a new concept in peripheral nerve surgery

et al. 2002

View full text Add to dashboard Cite

The popularity of nerve conduits has increased recently due to the need for alternative nerve reconstruction techniques, obviating the harvest of nerve grafts. Based on ideas suggesting nerve tissue itself, which was the most physiologic environment for nerve regeneration, a study using 40 sciatic nerves of 20 rats was performed. The proximal stumps of transected peroneal nerves were sutured to the lateral wall of healthy tibial nerve trunks after removal of the epineurium. Twelve weeks later, tissue samples were taken from the anastomosis sites and from the levels above and below these sites. Configurations of fascicles were evaluated, and numbers of fibers were estimated. It was observed that the fibers of peroneal nerves regenerated into and through the tibial nerve trunk distally. This suggested that active regenerating fibers of a proximal stump of a nerve could regenerate and progress as a fascicular unit in optimum condition at the trunk of another healthy nerve. This preliminary study should stimulate further studies based on this new concept: that a nerve trunk can serve as the host for the regenerating fibers of another nerve.

show abstract

Nerve growth factor: Cellular localization and regulation of synthesis

Cited by 64 publications

References 19 publications

Type III neuregulin 1 regulates pathfinding of sensory axons in the developing spinal cord and periphery

Type III neuregulin 1 regulates pathfinding of sensory axons in the developing spinal cord and periphery

S100 is present in developing chicken neurons and schwann cell and promotes motor neuron survival in vivo

Nerve regeneration through a healthy peripheral nerve trunk as a nerve conduit: A preliminary study of a new concept in peripheral nerve surgery

Contact Info

Product

Resources

About