“…The specific functions of CLU in the brain, however, are not as well-understood. Studies have shown that CLU expression is upregulated in degenerative conditions, such as AD (Calero et al, 2005 ; Nuutinen et al, 2009 ), due to cellular and oxidative stress or dysregulation of specific signaling pathways (Wong et al, 1994 ; Gutacker et al, 1999 ; Schepeler et al, 2007 ; Trougakos and Gonos, 2009 ). However, the literature provides conflicting results as to whether CLU expression improves or exacerbates cellular stress (Schreiber et al, 1993 ; Han et al, 2001 ; Imhof et al, 2006 ; Kim et al, 2012 ; Trindade et al, 2016 ; Troakes et al, 2017 ).…”