Nerve fibre and sensory end organ density in the epidermis and papillary dermis of the human hand

Kelly, Edward J.; Terenghi, Giorgio; Hazari, Anita; Wiberg, Mikael

doi:10.1016/j.bjps.2004.12.017

Cited by 60 publications

(53 citation statements)

References 19 publications

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“…This may be due to the shrinkage of the tissue caused by fixation and dehydration. The densities of the nerve fibers and sensory end organs have been reported in the epidermis in the human hand (Kelly et al, 2005). The number of intraepidermal nerve fibers ***per mm of epidermis was 9.0 to 12.3 in the sections of the skin of the fingers.…”

Section: Discussionmentioning

confidence: 95%

Distribution and Ultrastructure of Afferent Fibers in the Parietal Peritoneum of the Rat

Tanaka¹,

Hayakawa²,

Maeda³

et al. 2011

The Anatomical Record

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The distribution and the ultrastructure of afferent fibers innervating the parietal peritoneum in the rat was studied with immunohistochemistry using an antiserum against the neuronal marker protein gene product 9.5. The immunoreactive fibers were distributed throughout the peritoneum. They generally ran straight and parallel to the intercostal nerves running in the abdominal muscles underlying the peritoneum. They sometimes branched and terminated by forming club-like endings. The number of nerve endings on the peritoneal surface was 3.25 AE 1.66 mm À2 . Electron microscopic observations revealed both unmyelinated and myelinated nerve fibers. The unmyelinated fibers were thin and about 1 lm in diameter. Their endings formed slight swellings located just inside the peritoneal cell layer. The myelinated fibers often formed a bundle that was composed of two or three nerve fibers. Each myelinated fiber kept in contact with a Shwann cell and projected toward the peritoneal cavity. Finally, they penetrated the peritoneal cell layer to reach the peritoneal cavity. These fibers then made contacts with the peritoneal cells and became free from the myelin sheath. The ending had a club-like shape covered with collagen fibers, and contained many neurofilaments, a few mitochondria, but no synaptic vesicles. These results suggest that since the sensory endings are exposed at the peritoneal cavity, the sensory fibers are highly sensitive to somatic or nociceptive stimuli. Anat Rec, 294:1736Rec, 294: -1742Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 95%

Distribution and Ultrastructure of Afferent Fibers in the Parietal Peritoneum of the Rat

Tanaka¹,

Hayakawa²,

Maeda³

et al. 2011

The Anatomical Record

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“…Using immunofluorescence and light microscopy on 15μm thick sections from skin biopsies of various areas of the hand an IENFD of 10.3±8.3/mm (mean±SD) in glabrous skin of the proximal palm was reported. It was noted that inter-individual variability was high and that no specific pattern of distribution was found from fingertips to the palm (Kelly et al, 2005). A study on hairy skin from the distal forearm, using bright-field immunohistochemistry on 50μm thick sections reported a higher IENFD of 17.3±6.2/mm (Pan et al, 2001).…”

Section: Small Nerve Fibre Morphologymentioning

confidence: 99%

Diabetic Neuropathy – Nerve Morphology in the Upper Extremity

Thomsen¹,

Björkman²,

Dahlin³

2011

Recent Advances in the Pathogenesis, Prevention and Management of Type 2 Diabetes and Its Complications

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“…The use of PGP 9.5 immunolabelling provides a well-characterised and reliable method of identifying most of, if not all, the nerve fibres in the human skin (Kelly et al 2005). The p75 pan-neurotrophin receptor (the low-affinity form of NGFr) immunoreactivity in the Schwann cell membrane and on the axonal membrane of the cutaneous nerve fibres suggests an active role in the control and maintenance of normal sensory innervation (Liang & Johansson 1998).…”

mentioning

confidence: 99%

Cutaneous lesions sensory impairment recovery and nerve regeneration in leprosy patients

Illarramendi

Rangel

Miranda

et al. 2012

Mem. Inst. Oswaldo Cruz

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It is important to understand the mechanisms that enable peripheral neurons to regenerate after nerve injury in order to identify methods of improving this regeneration. Therefore, we studied nerve regeneration and sensory impairment recovery in the cutaneous lesions of leprosy patients (LPs) before and after treatment with multidrug therapy (MDT). The skin lesion sensory test results were compared to the histopathological and immunohistochemical protein gene product (PGP) 9.5 and the p75 nerve growth factor receptors (NGFr) findings. The cutaneous neural occupation ratio (CNOR) was evaluated for both neural markers. Thermal and pain sensations were the most frequently affected functions at the first visit and the most frequently recovered functions after MDT. The presence of a high cutaneous nerve damage index did not prevent the recovery of any type of sensory function. The CNOR was calculated for each biopsy, according to the presence of PGP and NGFr-immunostained fibres and it was not significantly different before or after the MDT. We observed a variable influence of MDT in the recovery from sensory impairment in the cutaneous lesions of LPs. Nociception and cold thermosensation were the most recovered sensations. The recovery of sensation in the skin lesions appeared to be associated with subsiding inflammation rather than with the regenerative activity of nerve fibres

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Nerve fibre and sensory end organ density in the epidermis and papillary dermis of the human hand

Cited by 60 publications

References 19 publications

Distribution and Ultrastructure of Afferent Fibers in the Parietal Peritoneum of the Rat

Distribution and Ultrastructure of Afferent Fibers in the Parietal Peritoneum of the Rat

Diabetic Neuropathy – Nerve Morphology in the Upper Extremity

Cutaneous lesions sensory impairment recovery and nerve regeneration in leprosy patients

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