Nerve fiber impairment of anterior thalamocortical circuitry in juvenile myoclonic epilepsy

Deppe, Michael; Kellinghaus, Christoph; Duning, Thomas; Möddel, Gabriel; Mohammadi, Siawoosh; Deppe, Katja; Schiffbauer, Hagen; Kugel, Harald; Keller, Simon S.; Ringelstein, E. B.; Knecht, Stefan

doi:10.1212/01.wnl.0000336969.98241.17

Cited by 119 publications

(130 citation statements)

References 33 publications

(29 reference statements)

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“…DTI studies have been reported in patients with epilepsy associated with frontal lobe dysfunction and they have found similar findings. DTI studies in juvenile myoclonic epilepsy, an idiopathic generalized epilepsy with frontal lobe dysfunctions, showed abnormal WM in supplementary motor area, bilateral superior and anterior corona radiata, genu and body of corpus callosum, and multiple superior and middle frontal WM tracts, and thalamofrontal connections (Deppe et al, 2008;Kim et al, 2012b;O'Muircheartaigh et al, 2011). The WM in the frontal lobe has also been examined using DTI in 12 children with drug resistant partial epilepsy (Holt et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Bilateral white matter abnormality in children with frontal lobe epilepsy

Widjaja

Kis

et al. 2014

Epilepsy Research

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SummaryIn frontal lobe epilepsy (FLE), interictal discharges and seizures are more likely to spread to contralateral hemisphere and become secondarily generalized. The aim of this study was to assess white matter (WM) integrity in children with FLE using diffusion tensor imaging (DTI). Children with FLE and normal MRI, and healthy controls with no neurological or psychiatric disorders underwent DTI on 3 T MRI. There was no significant association between FA or MD and clinical seizure parameters. The abnormal WM both ipsilateral and contralateral to seizure focus may be due to seizure activity or abnormal brain development.

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Section: Discussionmentioning

confidence: 99%

Bilateral white matter abnormality in children with frontal lobe epilepsy

Widjaja

Kis

et al. 2014

Epilepsy Research

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“…Since Gloor et al 3 first suggested that an abnormal cortical response to thalamocortical afferents might be responsible for generalized seizures, there is considerable evidence that thalamocortical networks are pathophysiologic in IGE. [4][5][6] Previous imaging studies have shown consistent structural and functional thalamic and cortical abnormalities, particularly in the frontal lobes, 7,8 and thalamofrontal white matter connectivity. 5 The thalamus and frontal lobes have extensive anatomic interconnectivity with bidirectional pathways 9 and both structures are involved in generalized spike wave discharges associated with IGE.…”

mentioning

confidence: 89%

“…[4][5][6] Previous imaging studies have shown consistent structural and functional thalamic and cortical abnormalities, particularly in the frontal lobes, 7,8 and thalamofrontal white matter connectivity. 5 The thalamus and frontal lobes have extensive anatomic interconnectivity with bidirectional pathways 9 and both structures are involved in generalized spike wave discharges associated with IGE. 10 The timing of the onset, manifestation, and development of thalamofrontal abnormalities in IGE is poorly defined.…”

mentioning

confidence: 89%

Thalamofrontal neurodevelopment in new-onset pediatric idiopathic generalized epilepsy

Pulsipher¹,

Dabbs²,

Tuchsherer³

et al. 2011

Neurology

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“…[8] can be constructed for each of the other EC deformations: [12] where the normalized coefficient vectors are given by:ˆ α n = c α n (n = x, y , z), and c is the same constant as in Eq. [7].…”

Section: Ec Field and Distortionsmentioning

confidence: 99%

“…, 13), where the i-th element of the EC vector contains the EC parameters obtained from the correction of the i-th DW image (see also Eq. [8]). To minimize interindividual variations, the EC vectors were averaged over 13 subjects (N sub = 13).…”

Section: Group-averaged Ec Parametersmentioning

confidence: 99%

Correcting eddy current and motion effects by affine whole‐brain registrations: Evaluation of three‐dimensional distortions and comparison with slicewise correction

Mohammadi

Möller

Kugel

et al. 2010

Magnetic Resonance in Med

133

142

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Eddy-current (EC) and motion effects in diffusion-tensor imaging (DTI) bias the estimation of quantitative diffusion indices, such as the fractional anisotropy. Both effects can be retrospectively corrected by registering the strongly distorted diffusion-weighted images to less-distorted T2-weighted images acquired without diffusion weighting. Two different affine spatial transformations are usually employed for this correction: slicewise and whole-brain transformations. However, a relation between estimated transformation parameters and EC distortions has not been established yet for the latter approach. In this study, a novel diffusion-gradient-direction-independent estimation of the EC field is proposed based solely on affine whole-brain registration parameters. Using this model, it is demonstrated that a more distinct evaluation of the wholebrain EC effects is possible if the through-plane distortion was considered in addition to the well-known in-plane distortions. Moreover, a comparison of different whole-brain registrations relative to a slicewise approach is performed, in terms of the relative tensor error. Our findings suggest that for appropriate intersubject comparison of DTI data, a whole-brain registration containing nine affine parameters provides comparable performance (between 0 and 3%) to slicewise methods and can be performed in a fraction of the time.Magn strong gradients used for diffusion encoding (in the following referred to as "diffusion gradients") create ECs in the conductive parts of the magnet, causing geometric distortions in the DW images that depend on the amplitude and direction of the diffusion gradients (11-14). The EC effects depend on the pulse sequence (15-18), scanner calibration, and scanner design. The EC and motion effects can be retrospectively corrected by registering the strongly distorted DW images to the less distorted images acquired without diffusion weighting (14,19). However, the EC effects cannot be completely corrected by retrospective registration. Thus, after retrospective EC correction residual image artifacts (e.g., image blurring caused by the time-dependent components of the EC field) will remain and reduce the comparability of DTI data. This is particularly important for longitudinal DTI studies, during which the scanner adjustment and, thus, the EC effects might vary.One possibility for assessing the comparability of DTI data is to quantify EC effects by estimating the induced EC field. Rohde et al. (20) presented a new registration approach for EC and motion correction, using a whole-brain transformation. They showed that the EC field induced by one diffusion gradient can be retrospectively estimated from the transformation parameters of a 14-parameter, nonlinear transformation that corrects the distortions of the corresponding DW image. The DTI data, however, consists of at least six DW images, each corresponding to different diffusion directions and containing EC distortions that are corrected by a specific set of EC parameters. Each respective set ...

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Nerve fiber impairment of anterior thalamocortical circuitry in juvenile myoclonic epilepsy

Abstract: The results support the hypothesis that juvenile myoclonic epilepsy is associated with abnormalities of the thalamocortical network that can be detected by diffusion tensor MRI.

Cited by 119 publications

References 33 publications

Bilateral white matter abnormality in children with frontal lobe epilepsy

Bilateral white matter abnormality in children with frontal lobe epilepsy

Thalamofrontal neurodevelopment in new-onset pediatric idiopathic generalized epilepsy

Correcting eddy current and motion effects by affine whole‐brain registrations: Evaluation of three‐dimensional distortions and comparison with slicewise correction

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